公开(公告)号：US20060281740A1

公开(公告)日：2006-12-14

申请号：US11451179

申请日：2006-06-12

Applicant: Yu-Hua Ji ,  Mathai Mammen ,  Craig Husfeld ,  Li Li ,  YongQi Mu ,  Aaron Kushner ,  Eric Stangeland ,  Trevor Mischki ,  Adam Hughes ,  Sarah Dunham

Inventor： Yu-Hua Ji ,  Mathai Mammen ,  Craig Husfeld ,  Li Li ,  YongQi Mu ,  Aaron Kushner ,  Eric Stangeland ,  Trevor Mischki ,  Adam Hughes ,  Sarah Dunham

IPC: C07D417/02 ,  C07D413/02 ,  C07D401/02 ,  C07D403/02 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/454

CPC classification number: C07D211/46 ,  C07D405/12 ,  C07D409/12 ,  C07D487/08

Abstract: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2， > 3 ，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US07514558B2

公开(公告)日：2009-04-07

申请号：US11604607

申请日：2006-11-27

Applicant: Mathai Mammen ,  Adam Hughes ,  Eric Stangeland ,  Yan Chen

Inventor： Mathai Mammen ,  Adam Hughes ,  Eric Stangeland ,  Yan Chen

IPC: A61K31/44 ,  C07D215/38

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US20070293461A1

公开(公告)日：2007-12-20

申请号：US11879829

申请日：2007-07-19

Applicant: Mathai Mammen ,  Yu-Hua Ji ,  Yong-Qi Mu ,  Eric Stangeland ,  Aaron Kushner ,  Craig Husfeld

Inventor： Mathai Mammen ,  Yu-Hua Ji ,  Yong-Qi Mu ,  Eric Stangeland ,  Aaron Kushner ,  Craig Husfeld

IPC: A61K31/56 ,  A61K31/45 ,  A61P11/08 ,  A61P9/00 ,  C07D211/06

CPC classification number: C07D211/62 ,  C07D211/60

Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，m，n，p，r，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7和W定义如上所述。 在规范中。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20060205779A1

公开(公告)日：2006-09-14

申请号：US11372294

申请日：2006-03-09

Applicant: YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Eric Stangeland

Inventor： YongQi Mu ,  Yu-Hua Ji ,  Mathai Mammen ,  Eric Stangeland

IPC: A61K31/445 ,  C07D211/54 ,  C07D211/40

CPC classification number: C07D211/46 ,  C07D405/12

Abstract: The invention provides compounds of formula I: wherein a, b, c, p, W, A, X1, R1, R2, R3, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，p，W，A，X 1，R 1，R 2， R 3，R 6，R 7和R 8如本说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20060205775A1

公开(公告)日：2006-09-14

申请号：US11371512

申请日：2006-03-09

Applicant: Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

Inventor： Yu-Hua Ji ,  Craig Husfeld ,  Li Li ,  Mathai Mammen ,  YongQi Mu ,  Eric Stangeland

IPC: A61K31/4545 ,  A61K31/454 ,  C07D401/02 ,  C07D403/02

CPC classification number: C07D405/14 ,  C07D211/62 ,  C07D401/12 ,  C07D409/14

Abstract: The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，d，n，R 1，R 2，R 3，R 7，R 7，W和A如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US08399488B2

公开(公告)日：2013-03-19

申请号：US13348085

申请日：2012-01-11

Applicant: YuHua Ji ,  Mathai Mammen ,  Craig Husfeld ,  Li Li ,  YongQi Mu ,  Aaron Kushner ,  Eric Stangeland ,  Trevor Mischki ,  Adam Hughes ,  Sarah Dunham

Inventor： YuHua Ji ,  Mathai Mammen ,  Craig Husfeld ,  Li Li ,  YongQi Mu ,  Aaron Kushner ,  Eric Stangeland ,  Trevor Mischki ,  Adam Hughes ,  Sarah Dunham

IPC: A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  C07D401/12

CPC classification number: C07D211/46 ,  C07D405/12 ,  C07D409/12 ,  C07D487/08

Abstract: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Abstract translation: 本发明提供式I化合物：其中a，b，c，m，s，t，w，Z，Ar，R 1，R 2，R 3，R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物，用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。

公开(公告)号：US20110312994A1

公开(公告)日：2011-12-22

申请号：US13011100

申请日：2011-01-21

Applicant: Mathai Mammen ,  Eric Stangeland

Inventor： Mathai Mammen ,  Eric Stangeland

IPC: A61K31/4709 ,  A61P11/08 ,  A61P11/06 ,  C07D401/12 ,  A61P11/00

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I的联苯衍生物：其中R1，R2，R3，R4，R5，R6，R7，W，a，b和c如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的联苯衍生物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

公开(公告)号：US20070208176A1

公开(公告)日：2007-09-06

申请号：US11788343

申请日：2007-04-19

Applicant: Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Weon Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

Inventor： Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Weon Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

IPC: C07D401/02

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US07141671B2

公开(公告)日：2006-11-28

申请号：US10779157

申请日：2004-02-13

Applicant: Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Weon Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

Inventor： Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Weon Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

IPC: C07D211/56 ,  C07D211/72 ,  A61K31/47 ,  A61K31/445

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

公开(公告)号：US20060223860A1

公开(公告)日：2006-10-05

申请号：US11448317

申请日：2006-06-07

Applicant: Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

Inventor： Mathai Mammen ,  Sarah Dunham ,  Adam Hughes ,  Tae Lee ,  Craig Husfeld ,  Eric Stangeland ,  Yan Chen

IPC: A61K31/445 ,  C07D211/54 ,  C07D211/56

CPC classification number: C07D211/46 ,  A61K31/445 ,  A61K31/452 ,  C07D211/48 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D453/02 ,  C07D471/08 ,  G01N33/9433

Abstract: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.

Abstract translation: 本发明提供式I的联苯衍生物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，W，a，b和c如说明书中所定义，或其药学上可接受的盐或 其溶剂合物或立体异构体。 本发明的联苯衍生物具有β2N2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺病和哮喘。