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![2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds](/abs-image/US/2014/03/18/US08673894B2/abs.jpg.150x150.jpg)
11.发明授权2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds 失效2,5,6,7-四氢 - [1,4]氧氮杂-3-基胺或2,3,6,7-四氢 - [1,4]氧氮杂-5-基胺化合物公开(公告)号：US08673894B2
公开(公告)日：2014-03-18
申请号：US13096059
申请日：2011-04-28
申请人： David Banner , Wolfgang Guba , Hans Hilpert , Roland Humm , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Didier Rombach , Thomas Woltering , Wolfgang Wostl
发明人： David Banner , Wolfgang Guba , Hans Hilpert , Roland Humm , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Didier Rombach , Thomas Woltering , Wolfgang Wostl
IPC分类号： A61P25/28 , A61K31/553 , C07D267/10 , C07D413/12 , C07D417/12
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.
摘要翻译： 本发明涉及下式化合物，其中A，B和R 1至R 7如下所述，或其药学上可接受的盐。 这些化合物是BACE1和/或BACE2抑制剂，可用作治疗和/或预防性治疗诸如阿尔茨海默病，糖尿病，特别是2型糖尿病和其它代谢紊乱的药物。
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![2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides](/abs-image/US/2013/03/05/US08389513B2/abs.jpg.150x150.jpg)
12.发明授权2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides 失效2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]恶嗪-4-基） - 苯基] - 酰胺公开(公告)号：US08389513B2
公开(公告)日：2013-03-05
申请号：US12959412
申请日：2010-12-03
申请人： David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
发明人： David Banner , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Emmanuel Pinard , Eoin Power , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
IPC分类号： C07D265/04 , A61K31/33
CPC分类号： C07D265/08 , C07D413/12
摘要： The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式I的2-氨基-5,5-二氟-5,6-二氢-4H- [1,3]恶嗪-4-基） - 苯基] - 酰胺 ，它们的制造，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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![2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS](/abs-image/US/2011/12/22/US20110312937A1/abs.jpg.150x150.jpg)
13.发明申请2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 失效2,5,6,7-四氢 - [1,4]氧杂环己烯-3-基胺或2,3,6,7-四氢 - [1,4]氧杂环己烯-5-胺化合物公开(公告)号：US20110312937A1
公开(公告)日：2011-12-22
申请号：US13096059
申请日：2011-04-28
申请人： David Banner , Wolfgang Guba , Hans Hilpert , Roland Humm , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Didier Rombach , Thomas Woltering , Wolfgang Wostl
发明人： David Banner , Wolfgang Guba , Hans Hilpert , Roland Humm , Harald Mauser , Alexander V. Mayweg , Robert Narquizian , Eoin Power , Mark Rogers-Evans , Didier Rombach , Thomas Woltering , Wolfgang Wostl
IPC分类号： A61K31/553 , A61P3/10 , C07D417/12 , A61P25/28 , C07D413/12 , C07D267/10
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of the formula wherein A, B and R1 to R7 are as described below, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as medicaments for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.
摘要翻译： 本发明涉及下式化合物，其中A，B和R 1至R 7如下所述，或其药学上可接受的盐。 这些化合物是BACE1和/或BACE2抑制剂，可用作治疗和/或预防性治疗诸如阿尔茨海默病，糖尿病，特别是2型糖尿病和其它代谢紊乱的药物。
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公开(公告)号：US20120196863A1
公开(公告)日：2012-08-02
申请号：US13357640
申请日：2012-01-25
申请人： Matteo Andreini , Emanuele Gabellieri , Robert Narquizian , Massimiliano Travagli , Wolfgang Wostl
发明人： Matteo Andreini , Emanuele Gabellieri , Robert Narquizian , Massimiliano Travagli , Wolfgang Wostl
IPC分类号： A61K31/5375 , C07D413/10 , A61K31/5377 , C07D413/14 , A61P3/10 , A61P25/28 , A61P29/00 , A61P37/02 , A61P35/00 , A61P9/10 , A61P25/00 , A61P17/00 , A61P1/00 , A61P5/00 , A61P19/02 , A61P21/00 , C07D265/30
CPC分类号： C07D413/10 , C07D265/30
摘要： The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供了具有BACE1和/或BACE2抑制活性的1,4型恶唑酸，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US08399459B2
公开(公告)日：2013-03-19
申请号：US13357640
申请日：2012-01-25
申请人： Matteo Andreini , Emanuele Gabellieri , Robert Narquizian , Massimiliano Travagli , Wolfgang Wostl
发明人： Matteo Andreini , Emanuele Gabellieri , Robert Narquizian , Massimiliano Travagli , Wolfgang Wostl
IPC分类号： A61K31/535 , C07D265/28
CPC分类号： C07D413/10 , C07D265/30
摘要： The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供了具有BACE1和/或BACE2抑制活性的1,4型恶唑酸，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US08785436B2
公开(公告)日：2014-07-22
申请号：US13467085
申请日：2012-05-09
申请人： Hans Hilpert , Robert Narquizian , Emmanuel Pinard , Alessandra Polara , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
发明人： Hans Hilpert , Robert Narquizian , Emmanuel Pinard , Alessandra Polara , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
IPC分类号： C07D413/04 , C07D413/10 , C07D413/12 , A61K31/5355
CPC分类号： C07D413/10 , C07D265/08 , C07D413/12
摘要： The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供具有BACE1和/或BACE2抑制活性的式I化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US20120295900A1
公开(公告)日：2012-11-22
申请号：US13467085
申请日：2012-05-09
申请人： Hans Hilpert , Robert Narquizian , Emmanuel Pinard , Alessandra Polara , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
发明人： Hans Hilpert , Robert Narquizian , Emmanuel Pinard , Alessandra Polara , Mark Rogers-Evans , Thomas Woltering , Wolfgang Wostl
IPC分类号： A61K31/5355 , C07D265/08 , C07D413/14 , A61K31/538 , C07D495/04 , A61P25/28 , A61P3/10 , A61P7/02 , A61P37/00 , A61P29/00 , A61P35/00 , A61P9/10 , A61P25/00 , A61P17/00 , A61P1/00 , A61P5/16 , A61P19/02 , A61K31/535 , C07D413/10 , C07D413/04 , A61P3/00 , C07D413/12
CPC分类号： C07D413/10 , C07D265/08 , C07D413/12
摘要： The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供具有BACE1和/或BACE2抑制活性的式I化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US08877744B2
公开(公告)日：2014-11-04
申请号：US13432003
申请日：2012-03-28
IPC分类号： A61K31/553 , C07D267/10 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D413/10 , C07D267/10 , C07D413/14 , C07D417/10
摘要： The present invention relates to 1,4 Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式I的1,4氧氮杂，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：US20120253035A1
公开(公告)日：2012-10-04
申请号：US13432003
申请日：2012-03-28
IPC分类号： C07D413/10 , C07D417/10 , C07D413/14 , C07D267/10
CPC分类号： C07D413/10 , C07D267/10 , C07D413/14 , C07D417/10
摘要： The present invention relates to 1,4 Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明涉及具有BACE1和/或BACE2抑制活性的式I的1,4氧氮杂，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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![Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors](/abs-image/US/2015/07/14/US09079919B2/abs.jpg.150x150.jpg)
20.发明授权Spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines as BACE1 and/or BACE2 inhibitors 有权螺 - [1,3] - 恶嗪和螺 - [1,4] - 氧氮杂作为BACE1和/或BACE2抑制剂公开(公告)号：US09079919B2
公开(公告)日：2015-07-14
申请号：US13476094
申请日：2012-05-21
IPC分类号： A61K31/537 , C07D265/08 , C07D413/12 , C07D413/14 , C07D498/10
CPC分类号： C07D498/10
摘要： The present invention provides spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供具有BACE1和/或BACE2抑制活性的式I的螺 - [1,3] - 恶嗪和螺 - [1,4] - 氧氮杂，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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