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公开(公告)号：US20070293457A1
公开(公告)日：2007-12-20
申请号：US11676120
申请日：2007-02-16
申请人： Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
发明人： Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
CPC分类号： A61K31/69 , C07F5/027 , Y02A50/411
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
摘要翻译： 公开了通过使用含硼小分子治疗抗炎症状况的方法。
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公开(公告)号：US20070286822A1
公开(公告)日：2007-12-13
申请号：US11762038
申请日：2007-06-12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.
摘要翻译： 提供了可用于治疗牙周病的化合物，组合物和方法。
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公开(公告)号：US20060234981A1
公开(公告)日：2006-10-19
申请号：US11357687
申请日：2006-02-16
申请人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20060019927A1
公开(公告)日：2006-01-26
申请号：US11152959
申请日：2005-06-14
IPC分类号： A61K31/69
CPC分类号： A61K31/69
摘要： Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the treatment of diseases caused by viruses are described.
摘要翻译： 描述了使用硼酸络合物，特别是羟基喹啉，咪唑和吡啶甲酸衍生物作为抗病毒剂的组合物和方法以及用于治疗由病毒引起的疾病的治疗剂。
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公开(公告)号：US4550163A
公开(公告)日：1985-10-29
申请号：US228414
申请日：1981-01-26
IPC分类号： C07F9/40 , G01N33/532 , G01N33/542 , C07F9/60
CPC分类号： G01N33/542 , C07F9/4075 , G01N33/532
摘要： The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction.The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.
摘要翻译： 本发明包括用于测定测试样品中配体的方法，包括与测试样品混合配体类似物不可逆酶抑制剂缀合物和可与该配体结合的结合蛋白和配体类似物不可逆酶抑制剂缀合物，其中配体类似物 由结合蛋白结合的可逆酶抑制剂缀合物与测试样品中配体的量相关，所述结合蛋白在结合到缀合物的配体类似物部分时使不可逆酶抑制剂失活; 混合由结合蛋白未结合的配体模拟不可逆酶抑制剂缀合物不可逆地抑制的酶; 并将底物与酶混合并监测酶底物反应。 本发明还包括在实施该方法中用作试剂的配体类似物不可逆酶抑制剂缀合物。 本发明的方法和试剂特别可用于确定生物流体中的药物，激素等。
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