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公开(公告)号：US20060234981A1
公开(公告)日：2006-10-19
申请号：US11357687
申请日：2006-02-16
申请人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent Hernandez , Karin Hold , James Leyden , Kirk Maples , Jacob Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20070293457A1
公开(公告)日：2007-12-20
申请号：US11676120
申请日：2007-02-16
申请人： Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
发明人： Stephen Baker , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk Maples , Jacob Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent Hernandez
CPC分类号： A61K31/69 , C07F5/027 , Y02A50/411
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
摘要翻译： 公开了通过使用含硼小分子治疗抗炎症状况的方法。
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公开(公告)号：US20070286822A1
公开(公告)日：2007-12-13
申请号：US11762038
申请日：2007-06-12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.
摘要翻译： 提供了可用于治疗牙周病的化合物，组合物和方法。
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公开(公告)号：US20050054644A1
公开(公告)日：2005-03-10
申请号：US10868268
申请日：2004-06-15
申请人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
发明人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
IPC分类号： A61K20060101 , A61K31/498 , A61K31/53 , A61K31/69 , C07D471/02 , C07D487/02 , C07F5/02
CPC分类号： C07F5/025
摘要： Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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5.发明申请公开(公告)号：US20070265226A1
公开(公告)日：2007-11-15
申请号：US11743665
申请日：2007-05-02
申请人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
发明人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
CPC分类号： C07F5/025
摘要： Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由真菌，酵母，细菌或病毒引起的疾病的治疗剂的硼衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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公开(公告)号：US20060019927A1
公开(公告)日：2006-01-26
申请号：US11152959
申请日：2005-06-14
IPC分类号： A61K31/69
CPC分类号： A61K31/69
摘要： Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives, as anti-viral agents as well as therapeutic agents for the treatment of diseases caused by viruses are described.
摘要翻译： 描述了使用硼酸络合物，特别是羟基喹啉，咪唑和吡啶甲酸衍生物作为抗病毒剂的组合物和方法以及用于治疗由病毒引起的疾病的治疗剂。
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公开(公告)号：US08440642B2
公开(公告)日：2013-05-14
申请号：US13224252
申请日：2011-09-01
申请人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US08039451B2
公开(公告)日：2011-10-18
申请号：US12507010
申请日：2009-07-21
申请人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20070155699A1
公开(公告)日：2007-07-05
申请号：US11505591
申请日：2006-08-16
申请人： Stephen Baker , Tsutomu Akama , Michael Alley , Steven Benkovic , Michael DiPierro , Vincent Hernandez , Karin Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob Plattner , Fernando Rock , Virginia Sanders , Aaron Stemphoski , George Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen Baker , Tsutomu Akama , Michael Alley , Steven Benkovic , Michael DiPierro , Vincent Hernandez , Karin Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob Plattner , Fernando Rock , Virginia Sanders , Aaron Stemphoski , George Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20060014723A1
公开(公告)日：2006-01-19
申请号：US11153010
申请日：2005-06-14
IPC分类号： A61K31/69
CPC分类号： A61K31/69 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/491
摘要： Compositions and methods of use of borinic acid complexes, especially hydroxyquinoline, imidazole and picolinic acid derivatives as anti-parasitic agents as well as therapeutic agents for the treatment of diseases caused by parasite are described.
摘要翻译： 描述了使用硼酸络合物，特别是羟基喹啉，咪唑和吡啶甲酸衍生物作为抗寄生虫剂的组合物和方法以及用于治疗由寄生虫引起的疾病的治疗剂。
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