公开(公告)号：US07512448B2

公开(公告)日：2009-03-31

申请号：US10340529

申请日：2003-01-10

申请人： Crista Malick ,  Xie Qi ,  Mitesh Parikh ,  Steve Franke ,  Douglas L. Jones ,  Jeffery B. Larsen ,  Christopher D. Schmitz ,  Francois Callias

发明人： Crista Malick ,  Xie Qi ,  Mitesh Parikh ,  Steve Franke ,  Douglas L. Jones ,  Jeffery B. Larsen ,  Christopher D. Schmitz ,  Francois Callias

IPC分类号： A61N1/05

CPC分类号： H04R25/552 ,  H04R25/558 ,  H04R25/606 ,  H04R2225/67

摘要： A number of ear-worn hearing system devices are provided that each include a pair of electrodes to transmit time varying electrical signals therebetween when in contact with skin of a user's body. The devices each include a housing, a sound sensor, and processing circuitry included within the housing. The electrodes are coupled to the circuitry and are spaced apart from one another a distance sufficient to provide capacitance between the electrodes below a desired threshold. The electrodes are disposed along the housing for placement on locations of the user's body where skin contact is not likely to be disrupted by nominal body movements.

摘要翻译： 提供了许多耳戴式听觉系统装置，每个听力系统装置包括一对电极，以在与用户身体的皮肤接触时在其间传递时变电信号。 这些装置各自包括壳体，声音传感器和包括在壳体内的处理电路。 电极耦合到电路并且彼此间隔开足以在电极之间提供低于期望阈值的电容的距离。 电极沿着壳体设置以放置在使用者身体的位置，其中皮肤接触不可能被标称身体运动中断。

公开(公告)号：US20090054248A1

公开(公告)日：2009-02-26

申请号：US11587867

申请日：2005-04-28

申请人： Michael H. Gollob ,  Douglas L. Jones ,  Andrew D. Krahn

发明人： Michael H. Gollob ,  Douglas L. Jones ,  Andrew D. Krahn

IPC分类号： C40B30/04 ,  C12Q1/68 ,  C12Q1/02 ,  C12N15/87 ,  C07H21/04 ,  C40B40/08

CPC分类号： C07K14/705 ,  A61K48/00 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N2333/705

摘要： A method of detecting cardiac arrhythmia in a patient is described. This method involves determining whether there is a mutation in the nucleotide sequence, the amino acid sequence, or both, of connexin40 obtained from a patient. The mutation may be localized within the transmembrane domain of connexin40. Furthermore, there is described a method of identifying a compound for the treatment of cardiac arrhythmia. This method involves providing a cell culture that is characterized by having impaired intracellular trafficking, impaired electrical coupling, reduced gap junction plaque formation, reduced intracellular coupling, or a combination thereof, when compared to a wild-type cell. A compound is added to the cell culture, and restoration of intracellular trafficking, electrical coupling, gap junction plaque formation, intracellular coupling, or a combination thereof, is monitored.

摘要翻译： 描述了一种检测患者心律失常的方法。 该方法包括确定从患者获得的连接蛋白40的核苷酸序列，氨基酸序列或两者是否存在突变。 突变可能位于连接蛋白40的跨膜结构域内。 此外，描述了鉴定用于治疗心律失常的化合物的方法。 该方法涉及提供细胞培养物，其特征在于与野生型细胞相比，其具有受损的细胞内运输，受损的电耦合，减少的间隙连接斑块形成，减少的细胞内偶联或其组合。 将化合物加入到细胞培养物中，监测细胞内运输，电耦合，间隙连接斑块形成，细胞内偶联或其组合的恢复。

公开(公告)号：US20080052390A1

公开(公告)日：2008-02-28

申请号：US11467729

申请日：2006-08-28

申请人： Douglas L. Jones ,  Bryan D. Osenbach

发明人： Douglas L. Jones ,  Bryan D. Osenbach

IPC分类号： G06F15/173 ,  H04L12/56

CPC分类号： H04L12/4641 ,  H04L29/12311 ,  H04L43/0811 ,  H04L61/2084

摘要： A system for virtual private network (VPN) address persistence is provided. The system includes a VPN capable network device, wherein the network device further includes a VPN data monitor and a VPN queuing device. The system may also include a server, an enterprise firewall, and/or a gateway server, each with its own local VPN data monitor and VPN queuing device in accordance with embodiments of the present invention.

摘要翻译： 提供了一种用于虚拟专用网（VPN）地址持久性的系统。 该系统包括具有VPN功能的网络设备，其中所述网络设备还包括VPN数据监视器和VPN排队设备。 根据本发明的实施例，该系统还可以包括服务器，企业防火墙和/或网关服务器，每个服务器具有其本身的本地VPN数据监视器和VPN排队设备。

公开(公告)号：US06978159B2

公开(公告)日：2005-12-20

申请号：US09805233

申请日：2001-03-13

申请人： Albert S. Feng ,  Chen Liu ,  Douglas L. Jones ,  Robert C. Bilger ,  Charissa R. Lansing ,  William D. O'Brien ,  Bruce C. Wheeler

发明人： Albert S. Feng ,  Chen Liu ,  Douglas L. Jones ,  Robert C. Bilger ,  Charissa R. Lansing ,  William D. O'Brien ,  Bruce C. Wheeler

IPC分类号： H04R25/00 ,  H04S1/00 ,  H04B1/00

CPC分类号： H04S1/007 ,  H04R25/407 ,  H04R25/552

摘要： A desired acoustic signal is extracted from a noisy environment by generating a signal representative of the desired signal with processor (30). Processor (30) receives aural signals from two sensors (22, 24) each at a different location. The two inputs to processor (30) are converted from analog to digital format and then submitted to a discrete Fourier transform process to generate discrete spectral signal representations. The spectral signals are delayed to provide a number of intermediate signals, each corresponding to a different spatial location relative to the two sensors. Locations of the noise source and the desired source, and the spectral content of the desired signal are determined from the intermediate signal corresponding to the noise source locations. Inverse transformation of the selected intermediate signal followed by digital to analog conversion provides an output signal representative of the desired signal with output device (90). Techniques to localize multiple acoustic sources are also disclosed. Further, a technique to enhance noise reduction from multiple sources based on two-sensor reception is described.

摘要翻译： 通过用处理器（30）产生表示期望信号的信号，从有噪声的环境中提取期望的声信号。 处理器（30）从不同位置的两个传感器（22,24）接收听觉信号。 处理器（30）的两个输入从模拟转换成数字格式，然后提交到离散傅立叶变换处理以产生离散的频谱信号表示。 频谱信号被延迟以提供多个中间信号，每个中间信号对应于相对于两个传感器的不同的空间位置。 从对应于噪声源位置的中间信号确定噪声源和期望源的位置以及期望信号的频谱含量。 所选择的中间信号的逆变换随后进行数模转换，由输出装置（90）提供代表期望信号的输出信号。 还公开了定位多个声源的技术。 此外，描述了一种基于双传感器接收来增强来自多个源的噪声降低的技术。