公开(公告)号：US08609897B2

公开(公告)日：2013-12-17

申请号：US13145190

申请日：2010-01-29

Applicant: Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

Inventor： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

IPC: C07C311/01 ,  A61K31/18

CPC classification number: C07D233/42 ,  C07C317/30 ,  C07C2601/14 ,  C07D295/185

Abstract: The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

Abstract translation: 本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制由推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。 该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。 当给予这样一个团体时，该化合物显示出显着和连续的Abeta降低，而不延长Notch相关的胃肠道毒性的表现，例如7天。 还包括药物组合物和使用方法。

公开(公告)号：US20130116231A1

公开(公告)日：2013-05-09

申请号：US13809436

申请日：2011-07-07

Applicant: Kevin Wilson ,  Michael Altman ,  Kathryn Lipford ,  Catherine White ,  Matthew Daniels

Inventor： Kevin Wilson ,  Michael Altman ,  Kathryn Lipford ,  Catherine White ,  Matthew Daniels

IPC: C07D411/14 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D411/14 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention relates to 1,4-dihydropyridazinone derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract translation: 本发明涉及1,4-二氢哒嗪酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

公开(公告)号：US20080067190A1

公开(公告)日：2008-03-20

申请号：US11935437

申请日：2007-11-06

Applicant: Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

Inventor： Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

IPC: G07F11/52 ,  G06F17/00

CPC classification number: G07F11/62 ,  G06F19/00 ,  G06F19/3462 ,  G07F11/44 ,  G07F11/70 ,  G07F13/10 ,  G07F17/0092

Abstract: An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

Abstract translation: 用于分配药物，特别是片剂和胶囊以及其它小型离散物体的自动化方法包括：接收处方信息，选择容器，标记容器，将片剂或胶囊分配到标记的容器中，将封闭物施加到填充的标记 容器，并将容器卸载到指定位置。 优选地，片剂被分配高速分配箱，其使用强制空气来搅动和分割片剂。 系统中的其他功能通常在设计用于为分配操作提供速度，灵活性和精度的站点执行。

公开(公告)号：US20080061077A1

公开(公告)日：2008-03-13

申请号：US11935433

申请日：2007-11-06

Applicant: Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

Inventor： Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

IPC: A61J1/03

CPC classification number: G07F11/62 ,  G06F19/00 ,  G06F19/3462 ,  G07F11/44 ,  G07F11/70 ,  G07F13/10 ,  G07F17/0092

Abstract: An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

公开(公告)号：US20060275051A1

公开(公告)日：2006-12-07

申请号：US11503601

申请日：2006-08-14

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: G03G15/00

CPC classification number: G03G21/181 ,  G03G15/0844 ,  G03G15/0894 ,  G03G21/12 ,  G03G21/1814 ,  G03G2215/0685 ,  G03G2221/1815 ,  G03G2221/1876

Abstract: A method for modifying a process cartridge includes providing the process cartridge comprising a waste bin having physical characteristics. The method further includes altering the physical characteristics of the waste bin to form an altered process cartridge.