公开(公告)号：US20130158041A1

公开(公告)日：2013-06-20

申请号：US13818312

申请日：2011-08-26

Applicant: Kevin Wilson ,  Matthew Daniels

Inventor： Kevin Wilson ,  Matthew Daniels

IPC: C07D403/14 ,  C07D403/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D237/04

CPC classification number: C07D403/14 ,  C07D237/04 ,  C07D237/18 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10

Abstract: The present invention relates to pyridazinthione derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract translation: 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病和用于抑制受体酪氨酸激酶MET的哒嗪二酮衍生物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

公开(公告)号：US20080061078A1

公开(公告)日：2008-03-13

申请号：US11935441

申请日：2007-11-06

Applicant: Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

Inventor： Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

IPC: A61J1/16

CPC classification number: G07F11/62 ,  G06F19/00 ,  G06F19/3462 ,  G07F11/44 ,  G07F11/70 ,  G07F13/10 ,  G07F17/0092

Abstract: An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

公开(公告)号：US20110275719A1

公开(公告)日：2011-11-10

申请号：US13145190

申请日：2010-01-29

Applicant: Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

Inventor： Matthew Daniels ,  Jed Hubbs ,  Thomas Miller

IPC: A61K31/18 ,  A61P25/28 ,  C07C305/18

CPC classification number: C07D233/42 ,  C07C317/30 ,  C07C2601/14 ,  C07D295/185

Abstract: The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound possesses favorable pharmacokinetic properties in higher species (rhesus) and thus can be dosed on an intermittent dosing regiment (e.g., once weekly). When dosed on such a regiment the compound exhibits significant and continuous Aβ lowering without the manifestation of Notch associated gastrointestinal toxicity for extended periods, e.g., 7 days. Pharmaceutical compositions and methods of use are also included.

Abstract translation: 本发明涉及一种新的三氟甲基磺酰胺衍生物，其抑制通过推定的γ-分泌酶处理APP，因此可用于治疗或预防阿尔茨海默氏病。 该化合物在较高种类（恒河猴）中具有有利的药代动力学性质，因此可以间歇给药剂量（例如每周一次）给药。 当这样一个团体配合时，该化合物显示出显着和连续的A＆Bgr; 降低Notch相关胃肠道毒性长期持续的表现，例如7天。 还包括药物组合物和使用方法。

公开(公告)号：US20060002734A1

公开(公告)日：2006-01-05

申请号：US11213203

申请日：2005-08-26

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: G03G15/00

CPC classification number: G03G21/181 ,  G03G15/0844 ,  G03G15/0894 ,  G03G21/12 ,  G03G21/1814 ,  G03G2215/0685 ,  G03G2221/1815 ,  G03G2221/1876

Abstract: A method for modifying a process cartridge includes providing the process cartridge comprising a waste bin having physical characteristics. The method further includes altering the physical characteristics of the waste bin to form an altered process cartridge.

公开(公告)号：US20070237543A1

公开(公告)日：2007-10-11

申请号：US11400693

申请日：2006-04-07

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: G03G15/00

CPC classification number: G03G15/00 ,  G03G15/0894 ,  G03G21/181 ,  G03G2215/0863 ,  G03G2221/1876

Abstract: Techniques are provided for modifying a printer cartridge and an imaging drum unit intended for installation in one type of printer to be installed in another type of printer or a plurality of printers. In one aspect, a method of modifying a toner cartridge may include modifying one or more end plate of the toner cartridge. In another aspect, a method of modifying a toner cartridge may include replacing one or more end plates of the toner cartridge with replacement end plates. In yet another aspect of the present invention, an imaging drum unit may include modifying one or more end plates of the imaging drum unit. In another aspect, an imaging drum unit may include replacing one or more end plates with replacement end plates.

公开(公告)号：US20050185982A1

公开(公告)日：2005-08-25

申请号：US11095444

申请日：2005-03-31

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: G03G15/08 ,  G03G21/12 ,  G03G15/00

CPC classification number: G03G21/181 ,  G03G15/0844 ,  G03G15/0894 ,  G03G21/12 ,  G03G21/1814 ,  G03G2215/0685 ,  G03G2221/1815 ,  G03G2221/1876

Abstract: A method for converting a process cartridge includes providing the process cartridge comprising a waste bin having physical characteristics. The process cartridge is suitable for use in a first type of printing device and not suitable for use in a second type of printing device. The method further includes altering the physical characteristics of the waste bin to form an altered process cartridge suitable for use in the second type of printing device.

Abstract translation: 一种用于转换处理盒的方法，包括提供包括具有物理特性的垃圾箱的处理盒。 处理盒适用于第一类型的打印装置，不适用于第二类型的打印装置。 该方法还包括改变垃圾箱的物理特征以形成适用于第二类型打印装置的改变的处理盒。

公开(公告)号：US06736487B2

公开(公告)日：2004-05-18

申请号：US10065227

申请日：2002-09-26

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: B49J294

CPC classification number: B41J2/17559 ,  B41J2/17553

Abstract: A printer cartridge and method of making or refurbishing a printer cartridge are disclosed. The printer cartridge may include a first cartridge subassembly attached to a second cartridge subassembly. The first cartridge subassembly may include a first conductive terminal and the second cartridge subassembly may include a second conductive terminal that is normally in electrical contact with the first conductive terminal when the first and second subassemblies are assembled. An external access may be provided to the first conductive terminal in the event the first conductive terminal is inaccessible after assembling the printer cartridge.

Abstract translation: 公开了一种打印机墨盒和制造或翻新打印机墨盒的方法。 打印机墨盒可以包括附接到第二墨盒子组件的第一墨盒子组件。 第一盒子组件可以包括第一导电端子，并且第二盒子组件可以包括第二导电端子，当组装第一和第二子组件时，第二导电端子通常与第一导电端子电接触。 在组装打印机墨盒之后第一导电端子不能接近的情况下，可以向第一导电端子提供外部访问。

公开(公告)号：US20130176893A1

公开(公告)日：2013-07-11

申请号：US13344284

申请日：2012-01-05

Applicant: Paul O. Caffrey ,  Matthew Daniels ,  Mark Asfaw

Inventor： Paul O. Caffrey ,  Matthew Daniels ,  Mark Asfaw

IPC: H04L12/28

CPC classification number: H04L12/462 ,  H04L12/4625

Abstract: Systems, methods, and apparatus for providing a communication network free of bridge loops by providing a first message from one of two bridges and a second message in response to the first message from the other of the two bridges and establishing a communicative path if both the first and second messages were received.

Abstract translation: 用于通过从两个网桥之一提供第一消息和响应于来自两个网桥中的另一个的第一消息而提供第一消息来提供没有桥接环路的通信网络的系统，方法和装置，并且如果两者都 收到第一和第二条消息。

公开(公告)号：US20080061075A1

公开(公告)日：2008-03-13

申请号：US11935430

申请日：2007-11-06

Applicant: Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

Inventor： Matthew Daniels ,  Jeffrey Williams ,  Richard Michelli ,  Jasper Pollard ,  Demetris Young ,  Joseph Moran ,  George Abrams ,  David Calderwood ,  Pete Klein

IPC: G07F11/00

CPC classification number: G07F11/62 ,  G06F19/00 ,  G06F19/3462 ,  G07F11/44 ,  G07F11/70 ,  G07F13/10 ,  G07F17/0092

Abstract: An automated method for dispensing pharmaceuticals, particularly tablets and capsules, and other small discrete objects, includes: receiving prescription information, selecting a container, labeling the container, dispensing the tablets or capsules into the labeled container, applying a closure to the filled, labeled container, and offloading the container to a designated location. Preferably, the tablets are dispensed with high speed dispensing bins that employ forced air to agitate and singulate the tablets. The other functions within the system are typically carried out at stations designed to offer speed, flexibility and precision to the dispensing operation.

公开(公告)号：US20070237542A1

公开(公告)日：2007-10-11

申请号：US11400352

申请日：2006-04-07

Applicant: Matthew Daniels

Inventor： Matthew Daniels

IPC: G03G15/00

CPC classification number: G03G15/0894 ,  G03G21/181 ,  G03G2221/1876

Abstract: Techniques are provided for modifying a printer cartridge and an imaging drum unit intended for installation in one type of printer to be installed in another type of printer or a plurality of printers. In one aspect, a method of modifying a toner cartridge may include modifying one or more end plate of the toner cartridge. In another aspect, a method of modifying a toner cartridge may include replacing one or more end plates of the toner cartridge with replacement end plates. In yet another aspect of the present invention, an imaging drum unit may include modifying one or more end plates of the imaging drum unit. In another aspect, an imaging drum unit may include replacing one or more end plates with replacement end plates.

Abstract translation: 提供了用于修改打印机盒和用于安装在一种类型的打印机中以安装在另一种类型的打印机或多个打印机中的成像鼓单元的技术。 在一个方面，修改调色剂盒的方法可以包括修改调色剂盒的一个或多个端板。 在另一方面，一种修改调色剂盒的方法可以包括用更换的端板替换调色剂盒的一个或多个端板。 在本发明的另一方面，成像鼓单元可以包括修改成像鼓单元的一个或多个端板。 在另一方面，成像鼓单元可以包括用替换的端板替换一个或多个端板。