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公开(公告)号：US08273870B2
公开(公告)日：2012-09-25
申请号：US13177316
申请日：2011-07-06
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： C07H21/04
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区 突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US07994309B2
公开(公告)日：2011-08-09
申请号：US12817009
申请日：2010-06-16
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： C07H21/04
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含互补RNA链，其具有与突变基因的一部分基本上互补的互补区，并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US07763590B2
公开(公告)日：2010-07-27
申请号：US10384463
申请日：2003-03-07
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： A61K48/00
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含互补RNA链，其具有与突变基因的一部分基本上互补的互补区，并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US20050119202A1
公开(公告)日：2005-06-02
申请号：US10493686
申请日：2002-10-25
IPC分类号： C12N15/09 , A61K9/127 , A61K9/50 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K38/00 , A61P31/14 , C07K14/18 , C07K14/82 , C12N15/113 , C12N15/40 , C12N15/51 , C12N15/88 , A61K48/00 , C07H21/02
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/14 , C12N2310/53
摘要： The invention concerns a medicament to treat a fibrotic disease, wherein the medicament contains a double-stranded ribonucleic acid (dsRNA) that is suitable for inhibiting by RNA interference the expression of a gene that is involved in the formation of extracellular matrix.
摘要翻译： 本发明涉及治疗纤维化疾病的药物，其中药物含有双链核糖核酸（dsRNA），其适用于通过RNA干扰参与细胞外基质形成的基因的表达。
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公开(公告)号：US20120322858A1
公开(公告)日：2012-12-20
申请号：US13594140
申请日：2012-08-24
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： A61K31/713 , C12N5/09 , C12N5/071 , C07H21/02 , A61P35/00
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区 突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US20110287090A1
公开(公告)日：2011-11-24
申请号：US13177316
申请日：2011-07-06
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： A61K31/713 , A61P35/02 , A61P35/00 , C07H21/02 , A61K9/127
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区 突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US20100291194A1
公开(公告)日：2010-11-18
申请号：US12817009
申请日：2010-06-16
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含互补RNA链，其具有与突变基因的一部分基本上互补的互补区，并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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公开(公告)号：US20050074757A1
公开(公告)日：2005-04-07
申请号：US10384463
申请日：2003-03-07
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： A61K38/00 , A61P35/00 , C12N7/01 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译： 本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含互补RNA链，其具有与突变基因的一部分基本上互补的互补区，并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。
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19.发明授权High-resolution three-dimensional medical imaging with dynamic real-time information 有权高分辨率三维医学影像与动态实时信息公开(公告)号：US09036880B2
公开(公告)日：2015-05-19
申请号：US12797759
申请日：2010-06-10
申请人： Ulrich Hartung , Matthias John
发明人： Ulrich Hartung , Matthias John
IPC分类号： G06K9/00 , A61B6/03 , A61B6/00 , A61B8/08 , A61B5/00 , A61B6/12 , A61B8/00 , A61B19/00 , G01R33/48 , G01R33/563
CPC分类号： A61B6/032 , A61B5/7285 , A61B6/12 , A61B6/4441 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/5247 , A61B6/541 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/483 , A61B8/5238 , A61B8/543 , A61B2090/364 , G01R33/4808 , G01R33/56308
摘要： A computer-implemented method, a device, a system and a computer program are disclosed for three-dimensional displaying of medical body structures within the framework of a medical procedure, in particular cardiac surgery, wherein movement information is derived from a dynamic image of a body structure to be examined. In at least one embodiment, movement information is derived from vector analysis. After acquiring a static image of the respective body structure, vector analysis is applied to the static image to derive a modified static image with movement information of the body structure. The static image can then be displayed after it has moved.
摘要翻译： 公开了一种计算机实现的方法，装置，系统和计算机程序，用于在医疗程序，特别是心脏手术的框架内的医疗体结构的三维显示，其中运动信息是从动态图像 身体结构要检查。 在至少一个实施例中，从矢量分析导出运动信息。 在获取相应身体结构的静态图像之后，将矢量分析应用于静态图像，以获得具有身体结构的运动信息的修改的静态图像。 静态图像可以在移动后显示。
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20.发明授权Method and system for catheter tracking in fluoroscopic images using adaptive discriminant learning and measurement fusion 有权使用自适应判别学习和测量融合的荧光镜图像中导管跟踪的方法和系统公开(公告)号：US09014423B2
公开(公告)日：2015-04-21
申请号：US13412882
申请日：2012-03-06
申请人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
发明人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
CPC分类号： A61B6/487 , A61B6/12 , A61B6/503 , G06T7/246 , G06T2207/10016 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30021 , G06T2207/30048
摘要： A method and system for adaptive discriminant learning and measurement fusion for image based catheter tracking is disclosed. An adaptive discriminant model is trained online based on a tracked object, such as a pigtail catheter tip, in at least one previous frame of a fluoroscopic image sequence. The object is tracked in the current frame of the fluoroscopic image sequence based at least on the adaptive discriminant model trained online. The object may be tracked in the current frame based on a fusion of three types of measurement models including the adaptive discriminant model trained online, an object detection model trained offline, and an online appearance model.
摘要翻译： 公开了一种用于基于图像的导管跟踪的自适应判别学习和测量融合的方法和系统。 在荧光镜像图像序列的至少一个先前帧中，基于跟踪对象（例如尾纤导管尖端）在线训练自适应判别模型。 至少基于在线训练的自适应判别模型，在透视图像序列的当前帧中跟踪对象。 基于三种类型的测量模型的融合，可以在当前帧中跟踪对象，包括在线训练的自适应判别模型，离线训练的对象检测模型和在线外观模型。
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