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    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER
    11.
    发明申请
    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER 审中-公开
    用于治疗增殖性疾病（如癌症）的四氢呋喃半胱氨酸

    公开(公告)号：US20090227577A1

    公开(公告)日：2009-09-10

    申请号：US12411486

    申请日：2009-03-26

    申请人： Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

    发明人： Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

    IPC分类号： A61K31/4365 ,  A61P25/00 ,  A61K31/506 ,  A61K31/5377

    CPC分类号： C07D495/04

    摘要： The invention relates to compounds of formula I, wherein Ra is —C(O)ORI, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Has, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

    摘要翻译： 本发明涉及式I化合物，其中R a为-C（O）ORI，其中R 1为1-7C-烷基，3-7C-环烷基或被一至四个取代基取代的1-7C-烷基，所述取代基独立地选自 R2，Rb是-TQ，其中T是1-6C-亚烷基或3-7C-亚环烷基，并且Q任选地被Rba和/或Rbb和/或Rbc取代，并且是苯基或萘基，或Q是任选的 被Rca和/或Rcb取代，并且是或者是Q被Rda和/或Rdb任选取代，并且是Het，或Q任选地被Rea和/或Reb取代，并且是3-7C-环烷基，它们是 可用于治疗过度增殖性疾病，特别是人类癌症。

    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER
    13.
    发明申请
    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER 审中-公开
    用于治疗增殖性疾病（如癌症）的四氢呋喃半胱氨酸

    公开(公告)号：US20100324038A1

    公开(公告)日：2010-12-23

    申请号：US12510362

    申请日：2009-07-28

    申请人： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

    发明人： Klaus Pekari ,  Mathias Schmidt ,  Thomas Bär ,  Thomas Beckers ,  Björn Bartels

    IPC分类号： A61K31/5377 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/506 ,  A61P35/00 ,  A61P35/02

    CPC分类号： C07D495/04

    摘要： The invention relates to compounds of formula I, wherein Ra is —C(O)OR1, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Har, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

    摘要翻译： 本发明涉及式I化合物，其中R a为-C（O）OR 1，其中R 1为1-7C-烷基，3-7C-环烷基或被一至四个独立地选自 R2，Rb是-TQ，其中T是1-6C-亚烷基或3-7C-亚环烷基，并且Q任选地被Rba和/或Rbb和/或Rbc取代，并且是苯基或萘基，或Q是任选的 被Rca和/或Rcb取代，并且是Har，或Q任选被R da和/或R db取代，并且是Het，或Q任选地被Rea和/或Reb取代，并且是3-7C-环烷基，它们是 可用于治疗过度增殖性疾病，特别是人类癌症。