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公开(公告)号:US20090209534A1
公开(公告)日:2009-08-20
申请号:US12412532
申请日:2009-03-27
申请人: Klaus PEKARI , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus PEKARI , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/4365 , A61P35/00 , A61K31/5377
CPC分类号: C07D495/04 , A61K31/4365
摘要: The use of tetrahydropyridothiophenes of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, is novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis.
摘要翻译: 使用具有式(I)的式(I)的四氢吡啶并噻吩,其中Ra和Rb具有说明书中所示的含义,其用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。
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公开(公告)号:US07517986B2
公开(公告)日:2009-04-14
申请号:US11597556
申请日:2005-06-03
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的式(I)化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20070259911A1
公开(公告)日:2007-11-08
申请号:US11628369
申请日:2005-06-10
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/4436 , A61P35/00 , C07D471/04
CPC分类号: C07D495/04 , A61K31/4365
摘要: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.
摘要翻译: 其中Ra和Rb具有本说明书中指出的含义的某种式(1)的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式(I)化合物,其中Ra和Rb具有说明书中所示的含义。
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公开(公告)号:US07723523B2
公开(公告)日:2010-05-25
申请号:US11597142
申请日:2005-05-25
申请人: Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Björn Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07714134B2
公开(公告)日:2010-05-11
申请号:US11628369
申请日:2005-06-10
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D471/02
CPC分类号: C07D495/04 , A61K31/4365
摘要: The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.
摘要翻译: 其中Ra和Rb具有本说明书中指出的含义的某种式(1)的化合物是新型的用于治疗对诱导凋亡有反应的过度增殖性疾病和/或病症。 本发明还涉及某些式(I)化合物,其中Ra和Rb具有说明书中所示的含义。
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公开(公告)号:US20070213360A1
公开(公告)日:2007-09-13
申请号:US11597556
申请日:2005-06-03
申请人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/4743 , C07D498/02
CPC分类号: C07D495/04
摘要: Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的式(I)化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07803945B2
公开(公告)日:2010-09-28
申请号:US12411740
申请日:2009-03-26
申请人: Klaus Pekari , Thomas Baer , Bjoern Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Bjoern Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: C07D513/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20070244112A1
公开(公告)日:2007-10-18
申请号:US11597142
申请日:2005-05-25
申请人: Klaus Pekari , Thomas Baer , Bjorn Bartels , Mathias Schmidt , Thomas Beckers
发明人: Klaus Pekari , Thomas Baer , Bjorn Bartels , Mathias Schmidt , Thomas Beckers
IPC分类号: A61K31/44 , A61K31/497 , A61K31/535 , A61P35/00 , C07D401/14 , C07D413/14 , C07D471/04
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20110044938A1
公开(公告)日:2011-02-24
申请号:US12377539
申请日:2007-08-15
申请人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
发明人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
IPC分类号: A61K31/381 , C07D409/14 , C07D409/12 , C07D333/68 , C07D413/12 , C07D413/14 , A61K31/444 , A61K31/4436 , A61K31/5377 , A61K31/4178 , A61K31/4545 , A61K31/661 , A61K31/675 , A61K33/24 , A61K31/437 , A61K31/704 , A61K31/513 , A61K31/44 , A61K31/404 , A61K31/517 , A61K39/395 , A61K38/20 , A61P35/00 , A61P35/02
CPC分类号: C07D333/68 , C07D409/12 , C07D409/14
摘要: Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式I化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07714136B2
公开(公告)日:2010-05-11
申请号:US11920572
申请日:2006-05-24
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
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