TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER
    3.
    发明申请
    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER 审中-公开
    用于治疗增殖性疾病(如癌症)的四氢呋喃半胱氨酸

    公开(公告)号:US20100324038A1

    公开(公告)日:2010-12-23

    申请号:US12510362

    申请日:2009-07-28

    CPC分类号: C07D495/04

    摘要: The invention relates to compounds of formula I, wherein Ra is —C(O)OR1, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Har, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

    摘要翻译: 本发明涉及式I化合物,其中R a为-C(O)OR 1,其中R 1为1-7C-烷基,3-7C-环烷基或被一至四个独立地选自 R2,Rb是-TQ,其中T是1-6C-亚烷基或3-7C-亚环烷基,并且Q任选地被Rba和/或Rbb和/或Rbc取代,并且是苯基或萘基,或Q是任选的 被Rca和/或Rcb取代,并且是Har,或Q任选被R da和/或R db取代,并且是Het,或Q任选地被Rea和/或Reb取代,并且是3-7C-环烷基,它们是 可用于治疗过度增殖性疾病,特别是人类癌症。