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16 条记录 (耗时 0.025 秒)

    Visualization of states of a process
    11.
    发明授权
    Visualization of states of a process 有权
    过程状态的可视化

    公开(公告)号：US09141507B2

    公开(公告)日：2015-09-22

    申请号：US12646155

    申请日：2009-12-23

    申请人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    发明人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    IPC分类号： G06F3/00 ,  G06F11/32 ,  G06F3/01 ,  G06F11/36

    CPC分类号： G06F11/323 ,  G06F11/3664

    摘要： A method of providing a visualization of states of a process includes identifying a set of potential states that can occur during the process and a corresponding set of colors, with each color in the set of colors corresponding to one of the potential states. A fixed ordering is established for the set of colors. A timeline graph including a plurality of colored vertical bars is displayed. Each colored vertical bar corresponds to a time interval of the process and includes at least one color selected from the set of colors based on at least one state occurring during the time interval corresponding to the vertical bar. The plurality of colored vertical bars includes a set of multiple-color vertical bars that each include a plurality of colors appearing in a vertical order based on the fixed ordering.

    摘要翻译： 提供过程状态可视化的方法包括识别可在过程期间发生的一组潜在状态和相应的一组颜色，其中该组颜色中的每种颜色对应于潜在状态之一。 为该组颜色建立固定的顺序。 显示包括多个彩色垂直条的时间线图。 每个彩色垂直条对应于处理的时间间隔，并且基于在对应于垂直条的时间间隔期间发生的至少一个状态，包括从该组颜色中选择的至少一种颜色。 多个彩色垂直条包括一组多色垂直条，每一个垂直条都包含基于固定顺序以垂直顺序出现的多种颜色。

    VISUALIZATION OF STATES OF A PROCESS
    12.
    发明申请
    VISUALIZATION OF STATES OF A PROCESS 有权
    过程状态的可视化

    公开(公告)号：US20110154245A1

    公开(公告)日：2011-06-23

    申请号：US12646155

    申请日：2009-12-23

    申请人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    发明人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    IPC分类号： G06F3/048

    CPC分类号： G06F11/323 ,  G06F11/3664

    摘要： A method of providing a visualization of states of a process includes identifying a set of potential states that can occur during the process and a corresponding set of colors, with each color in the set of colors corresponding to one of the potential states. A fixed ordering is established for the set of colors. A timeline graph including a plurality of colored vertical bars is displayed. Each colored vertical bar corresponds to a time interval of the process and includes at least one color selected from the set of colors based on at least one state occurring during the time interval corresponding to the vertical bar. The plurality of colored vertical bars includes a set of multiple-color vertical bars that each include a plurality of colors appearing in a vertical order based on the fixed ordering.

    摘要翻译： 提供过程状态可视化的方法包括识别可在过程期间发生的一组潜在状态和相应的一组颜色，其中该组颜色中的每种颜色对应于潜在状态之一。 为该组颜色建立固定的顺序。 显示包括多个彩色垂直条的时间线图。 每个彩色垂直条对应于处理的时间间隔，并且基于在对应于垂直条的时间间隔期间发生的至少一个状态，包括从该组颜色中选择的至少一种颜色。 多个彩色垂直条包括一组多色垂直条，每一个垂直条都包含基于固定顺序以垂直顺序出现的多种颜色。

    O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates
    13.
    发明授权
    O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates 有权
    O-芳基化或O-糖基化的1-取代的二氮-1-烯-1,2-二醇酯和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- ium -1,2-二醇酯

    公开(公告)号：US06610660B1

    公开(公告)日：2003-08-26

    申请号：US09254301

    申请日：1999-05-03

    申请人： Joseph E. Saavedra ,  Larry K. Keefer ,  Aloka Srinivasan ,  William G. Rice ,  Xinhua Ji ,  Christian Bogdan

    发明人： Joseph E. Saavedra ,  Larry K. Keefer ,  Aloka Srinivasan ,  William G. Rice ,  Xinhua Ji ,  Christian Bogdan

    IPC分类号： C07D29522

    CPC分类号： C07D213/64 ,  C07C291/08 ,  C07D207/16 ,  C07D239/34 ,  C07D295/30 ,  C07H19/06 ,  C07H19/16

    摘要： Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

    摘要翻译： 二氮烯鎓二硫醇盐，其中N1位被无机或有机部分取代，并且O-氧与取代或未取代的芳族基团结合。 还提供了O-糖基化的1-取代的二氮嗪-1-铋-1,2-二醇酯（O 2 - 糖基化的二氮烯鎓二醇酯）和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- 1,2-二醇化物（1 - [（2-羧基）吡咯烷-1-基]二氮烯鎓二硫醇盐）。 相对于中性至酸性溶液中的一氧化氮的水解产生，氧芳基二氮烯鎓二硫醇盐是稳定的，并在碱性或亲核环境或微环境中产生一氧化氮。 还提供了包含这些化合物的药物组合物和使用这些化合物的方法的组合物。

    LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS
    15.
    发明申请
    LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS 有权

    公开(公告)号：US20130172285A1

    公开(公告)日：2013-07-04

    申请号：US13704857

    申请日：2011-06-01

    申请人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    发明人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    IPC分类号： C07H19/167 ,  G06F19/16 ,  C07D475/04

    CPC分类号： C07H19/16 ,  C07D475/04 ,  C07H19/167 ,  G06F19/16

    摘要： The disclosure provides linked purine pterin compounds and analogues thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general Formula I The variables, e.g. A1 to A3, R1 to R4, L1, L2, B1, and B2 are described herein. Compounds and salts of Formula I bind to HPPK with high affinity and specificity. Pharmaceutical compositions containing an HPPK inhibitor of Formula I and methods of treating a bacterial infection in a patient by providing one or more HPPK inhibitors of Formula I to the patient are also provided. Processes and intermediates useful for preparing compounds of Formula I are also provided. Methods of using the disclosed compounds to guide the development of additional novel anti-bacterial agents are also provided.

    Linked purine pterin HPPK inhibitors useful as antibacterial agents
    16.
    发明授权
    Linked purine pterin HPPK inhibitors useful as antibacterial agents 有权
    连接的嘌呤蝶呤HPPK抑制剂可用作抗菌剂

    公开(公告)号：US09029344B2

    公开(公告)日：2015-05-12

    申请号：US13704857

    申请日：2011-06-01

    申请人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    发明人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    IPC分类号： A61K31/70 ,  A61K31/50 ,  C07H19/16 ,  C07D475/00 ,  C07H19/167 ,  C07D475/04 ,  G06F19/16

    CPC分类号： C07H19/16 ,  C07D475/04 ,  C07H19/167 ,  G06F19/16

    摘要： The disclosure provides linked purine pterin compounds and analogs thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general Formula I The variables, e.g. A1 to A3, R1 to R4, L1, L2, B1, and B2 are described herein. Compounds and salts of Formula I bind to HPPK with high affinity and specificity. Pharmaceutical compositions containing an HPPK inhibitor of Formula I and methods of treating a bacterial infection in a patient by providing one or more HPPK inhibitors of Formula I to the patient are also provided. Processes and intermediates useful for preparing compounds of Formula I are also provided. Methods of using the disclosed compounds to guide the development of additional novel anti-bacterial agents are also provided.

    摘要翻译： 本公开提供了连接的嘌呤蝶呤化合物及其类似物，其是新型HPPK抑制剂。 本文所述的HPPK抑制剂是通式I的化合物及其药学上可接受的盐。 A1〜A3，R1〜R4，L1，L2，B1，B2。 式I的化合物和盐以高亲和力和特异性结合HPPK。 还提供了含有式I的HPPK抑制剂和通过向患者提供一种或多种式I的HPPK抑制剂来治疗患者细菌感染的方法的药物组合物。 还提供了可用于制备式I化合物的方法和中间体。 还提供了使用所公开的化合物指导另外的新型抗菌剂的开发的方法。