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    Linked purine pterin HPPK inhibitors useful as antibacterial agents
    1.
    发明授权
    Linked purine pterin HPPK inhibitors useful as antibacterial agents 有权
    连接的嘌呤蝶呤HPPK抑制剂可用作抗菌剂

    公开(公告)号：US09029344B2

    公开(公告)日：2015-05-12

    申请号：US13704857

    申请日：2011-06-01

    申请人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    发明人： Genbin Shi ,  Gary X. Shaw ,  Xinhua Ji

    IPC分类号： A61K31/70 ,  A61K31/50 ,  C07H19/16 ,  C07D475/00 ,  C07H19/167 ,  C07D475/04 ,  G06F19/16

    CPC分类号： C07H19/16 ,  C07D475/04 ,  C07H19/167 ,  G06F19/16

    摘要： The disclosure provides linked purine pterin compounds and analogs thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general Formula I The variables, e.g. A1 to A3, R1 to R4, L1, L2, B1, and B2 are described herein. Compounds and salts of Formula I bind to HPPK with high affinity and specificity. Pharmaceutical compositions containing an HPPK inhibitor of Formula I and methods of treating a bacterial infection in a patient by providing one or more HPPK inhibitors of Formula I to the patient are also provided. Processes and intermediates useful for preparing compounds of Formula I are also provided. Methods of using the disclosed compounds to guide the development of additional novel anti-bacterial agents are also provided.

    摘要翻译： 本公开提供了连接的嘌呤蝶呤化合物及其类似物，其是新型HPPK抑制剂。 本文所述的HPPK抑制剂是通式I的化合物及其药学上可接受的盐。 A1〜A3，R1〜R4，L1，L2，B1，B2。 式I的化合物和盐以高亲和力和特异性结合HPPK。 还提供了含有式I的HPPK抑制剂和通过向患者提供一种或多种式I的HPPK抑制剂来治疗患者细菌感染的方法的药物组合物。 还提供了可用于制备式I化合物的方法和中间体。 还提供了使用所公开的化合物指导另外的新型抗菌剂的开发的方法。

    Calculating zoom level timeline data
    2.
    发明授权
    Calculating zoom level timeline data 有权
    计算缩放级别时间轴数据

    公开(公告)号：US08941657B2

    公开(公告)日：2015-01-27

    申请号：US13113422

    申请日：2011-05-23

    申请人： Mayank Agarwal ,  Xinhua Ji ,  Alexander Dadiomov

    发明人： Mayank Agarwal ,  Xinhua Ji ,  Alexander Dadiomov

    IPC分类号： G06T11/20 ,  G09G5/00 ,  G06F17/30

    CPC分类号： G06F17/30551 ,  G06F17/30572

    摘要： The present invention extends to methods, systems, and computer program products for calculating zoom level timeline data. Event aggregators are configured to read execution data from sequentially received input buffers and pre-calculate data chunks for a specified zoom level to create a zoom tree. The density of execution data can be used to determine when pre-calculation is beneficial. In response to a user request, pre-calculated data can be combined with responsively calculated data for presentation to a user. User requests can specify zoom levels and time ranges over which data is to be presented.

    摘要翻译： 本发明扩展到用于计算缩放级别时间轴数据的方法，系统和计算机程序产品。 事件聚合器被配置为从顺序接收的输入缓冲区读取执行数据，并预先计算指定缩放级别的数据块以创建缩放树。 执行数据的密度可用于确定何时预计算有益。 响应于用户请求，可以将预先计算的数据与响应计算的数据组合以呈现给用户。 用户请求可以指定要显示数据的缩放级别和时间范围。

    CALCULATING ZOOM LEVEL TIMELINE DATA
    3.
    发明申请
    CALCULATING ZOOM LEVEL TIMELINE DATA 有权
    计算变焦级时间轴数据

    公开(公告)号：US20120299965A1

    公开(公告)日：2012-11-29

    申请号：US13113422

    申请日：2011-05-23

    申请人： Mayank Agarwal ,  Xinhua Ji ,  Alexander Dadiomov

    发明人： Mayank Agarwal ,  Xinhua Ji ,  Alexander Dadiomov

    IPC分类号： G09G5/00

    CPC分类号： G06F17/30551 ,  G06F17/30572

    摘要： The present invention extends to methods, systems, and computer program products for calculating zoom level time line data. Event aggregators are configured to read execution data from sequentially received input buffers and pre-calculate data chunks for a specified zoom level to create a zoom tree. The density of execution data can be used to determine when pre-calculation is beneficial. In response to a user request, pre-calculated data can be combined with responsively calculated data for presentation to a user. User requests can specify zoom levels and time ranges over which data is to be presented.

    摘要翻译： 本发明扩展到用于计算缩放级时间线数据的方法，系统和计算机程序产品。 事件聚合器被配置为从顺序接收的输入缓冲区读取执行数据，并预先计算指定缩放级别的数据块以创建缩放树。 执行数据的密度可用于确定何时预计算有益。 响应于用户请求，可以将预先计算的数据与响应计算的数据组合以呈现给用户。 用户请求可以指定要显示数据的缩放级别和时间范围。

    DYNAMIC CALCULATION OF SAMPLE PROFILE REPORTS
    4.
    发明申请
    DYNAMIC CALCULATION OF SAMPLE PROFILE REPORTS 有权
    动态计算样品轮廓报告

    公开(公告)号：US20120054721A1

    公开(公告)日：2012-03-01

    申请号：US12868495

    申请日：2010-08-25

    申请人： Alexander Dadiomov ,  Mayank Agarwal ,  Xinhua Ji

    发明人： Alexander Dadiomov ,  Mayank Agarwal ,  Xinhua Ji

    IPC分类号： G06F9/44

    CPC分类号： G06F11/3612 ,  G06F11/3419 ,  G06F11/3466 ,  G06F2201/865

    摘要： The construction or use of a hierarchical time tree that represents an execution time of a program. To construct the hierarchical time tree, the time frame corresponding to the root node is the execution time during which the plurality of call stack samples were gathered from the program. Beginning at the root node, and proceeding recursively, each node is then populated in a manner that all of the call stacks for a given time period need not be accessed in order to provide a report regarding the given time period.

    摘要翻译： 构建或使用代表程序执行时间的分层时间树。 为了构建分层时间树，与根节点对应的时间帧是从节目收集多个呼叫堆栈样本的执行时间。 从根节点开始，并递归进行，然后以不必访问给定时间段内的所有呼叫栈的方式填充每个节点，以便提供关于给定时间段的报告。

    Visualization of states of a process
    5.
    发明授权
    Visualization of states of a process 有权
    过程状态的可视化

    公开(公告)号：US09141507B2

    公开(公告)日：2015-09-22

    申请号：US12646155

    申请日：2009-12-23

    申请人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    发明人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    IPC分类号： G06F3/00 ,  G06F11/32 ,  G06F3/01 ,  G06F11/36

    CPC分类号： G06F11/323 ,  G06F11/3664

    摘要： A method of providing a visualization of states of a process includes identifying a set of potential states that can occur during the process and a corresponding set of colors, with each color in the set of colors corresponding to one of the potential states. A fixed ordering is established for the set of colors. A timeline graph including a plurality of colored vertical bars is displayed. Each colored vertical bar corresponds to a time interval of the process and includes at least one color selected from the set of colors based on at least one state occurring during the time interval corresponding to the vertical bar. The plurality of colored vertical bars includes a set of multiple-color vertical bars that each include a plurality of colors appearing in a vertical order based on the fixed ordering.

    摘要翻译： 提供过程状态可视化的方法包括识别可在过程期间发生的一组潜在状态和相应的一组颜色，其中该组颜色中的每种颜色对应于潜在状态之一。 为该组颜色建立固定的顺序。 显示包括多个彩色垂直条的时间线图。 每个彩色垂直条对应于处理的时间间隔，并且基于在对应于垂直条的时间间隔期间发生的至少一个状态，包括从该组颜色中选择的至少一种颜色。 多个彩色垂直条包括一组多色垂直条，每一个垂直条都包含基于固定顺序以垂直顺序出现的多种颜色。

    VISUALIZATION OF STATES OF A PROCESS
    8.
    发明申请
    VISUALIZATION OF STATES OF A PROCESS 有权
    过程状态的可视化

    公开(公告)号：US20110154245A1

    公开(公告)日：2011-06-23

    申请号：US12646155

    申请日：2009-12-23

    申请人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    发明人： Xinhua Ji ,  Alexander Dadiomov ,  Hazim Shafi ,  Eric Ledoux ,  William T. Colburn

    IPC分类号： G06F3/048

    CPC分类号： G06F11/323 ,  G06F11/3664

    摘要： A method of providing a visualization of states of a process includes identifying a set of potential states that can occur during the process and a corresponding set of colors, with each color in the set of colors corresponding to one of the potential states. A fixed ordering is established for the set of colors. A timeline graph including a plurality of colored vertical bars is displayed. Each colored vertical bar corresponds to a time interval of the process and includes at least one color selected from the set of colors based on at least one state occurring during the time interval corresponding to the vertical bar. The plurality of colored vertical bars includes a set of multiple-color vertical bars that each include a plurality of colors appearing in a vertical order based on the fixed ordering.

    摘要翻译： 提供过程状态可视化的方法包括识别可在过程期间发生的一组潜在状态和相应的一组颜色，其中该组颜色中的每种颜色对应于潜在状态之一。 为该组颜色建立固定的顺序。 显示包括多个彩色垂直条的时间线图。 每个彩色垂直条对应于处理的时间间隔，并且基于在对应于垂直条的时间间隔期间发生的至少一个状态，包括从该组颜色中选择的至少一种颜色。 多个彩色垂直条包括一组多色垂直条，每一个垂直条都包含基于固定顺序以垂直顺序出现的多种颜色。

    Dynamic calculation of sample profile reports
    10.
    发明授权
    Dynamic calculation of sample profile reports 有权
    动态计算样本资料报告

    公开(公告)号：US08510721B2

    公开(公告)日：2013-08-13

    申请号：US12868495

    申请日：2010-08-25

    申请人： Alexander Dadiomov ,  Mayank Agarwal ,  Xinhua Ji

    发明人： Alexander Dadiomov ,  Mayank Agarwal ,  Xinhua Ji

    IPC分类号： G06F9/44

    CPC分类号： G06F11/3612 ,  G06F11/3419 ,  G06F11/3466 ,  G06F2201/865

    摘要： The construction or use of a hierarchical time tree that represents an execution time of a program. To construct the hierarchical time tree, the time frame corresponding to the root node is the execution time during which the plurality of call stack samples were gathered from the program. Beginning at the root node, and proceeding recursively, each node is then populated in a manner that all of the call stacks for a given time period need not be accessed in order to provide a report regarding the given time period.

    摘要翻译： 构建或使用代表程序执行时间的分层时间树。 为了构建分层时间树，与根节点对应的时间帧是从节目收集多个呼叫堆栈样本的执行时间。 从根节点开始，并递归进行，然后以不必访问给定时间段内的所有呼叫栈的方式填充每个节点，以便提供关于给定时间段的报告。