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    O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates
    1.
    发明授权
    O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates 有权
    O-芳基化或O-糖基化的1-取代的二氮-1-烯-1,2-二醇酯和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- ium -1,2-二醇酯

    公开(公告)号：US06610660B1

    公开(公告)日：2003-08-26

    申请号：US09254301

    申请日：1999-05-03

    申请人： Joseph E. Saavedra ,  Larry K. Keefer ,  Aloka Srinivasan ,  William G. Rice ,  Xinhua Ji ,  Christian Bogdan

    发明人： Joseph E. Saavedra ,  Larry K. Keefer ,  Aloka Srinivasan ,  William G. Rice ,  Xinhua Ji ,  Christian Bogdan

    IPC分类号： C07D29522

    CPC分类号： C07D213/64 ,  C07C291/08 ,  C07D207/16 ,  C07D239/34 ,  C07D295/30 ,  C07H19/06 ,  C07H19/16

    摘要： Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

    摘要翻译： 二氮烯鎓二硫醇盐，其中N1位被无机或有机部分取代，并且O-氧与取代或未取代的芳族基团结合。 还提供了O-糖基化的1-取代的二氮嗪-1-铋-1,2-二醇酯（O 2 - 糖基化的二氮烯鎓二醇酯）和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- 1,2-二醇化物（1 - [（2-羧基）吡咯烷-1-基]二氮烯鎓二硫醇盐）。 相对于中性至酸性溶液中的一氧化氮的水解产生，氧芳基二氮烯鎓二硫醇盐是稳定的，并在碱性或亲核环境或微环境中产生一氧化氮。 还提供了包含这些化合物的药物组合物和使用这些化合物的方法的组合物。