公开(公告)号：US10413411B2

公开(公告)日：2019-09-17

申请号：US15292425

申请日：2016-10-13

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork

IPC: A61F2/24 ,  A61F2/966

Abstract: A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft assembly, a delivery sheath assembly, an outer stability tube, and a handle. The sheath assembly is slidably disposed over the inner shaft, and includes a capsule and a shaft. The capsule compressively contains the prosthesis over the inner shaft. The stability tube is slidably disposed over the delivery sheath, and includes a distal region configured to be radially expandable from a first shape having a first diameter to a second shape having a larger, second diameter. In a first delivery state, the distal region assumes the first shape, providing a low profile appropriate for traversing a patient's vasculature. In a second delivery state, the distal region has the expanded diameter second shape, sized to receive the capsule, such as when retracting the capsule to implant the prosthesis.

公开(公告)号：US10383727B2

公开(公告)日：2019-08-20

申请号：US15838717

申请日：2017-12-12

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork

IPC: A61F2/24

Abstract: A heart valve prosthesis and delivery systems are provided for replacing a cardiac valve. The heart valve prosthesis includes a self-expanding frame includes a portion having a crimp that provides additional flexibility to the self-expanding frame in the collapsed configuration.

公开(公告)号：US09132008B2

公开(公告)日：2015-09-15

申请号：US14505694

申请日：2014-10-03

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Glenn Stante ,  Adam Shipley

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2002/9505 ,  A61F2230/0054 ,  A61F2230/008

Abstract: A delivery device for percutaneously deploying a prosthetic valve includes a sheath, an inner shaft, and a release assembly. The release assembly is disposed between the sheath and the inner shaft, and includes a retraction member, a release member, and a retention member. The retraction member can self-retract in length from an extended condition to a retracted condition. The release member can self-expand from a compressed condition to an expanded condition. The retention member is distal the release member. In a delivery state, the sheath end is distal the retention member, the release member is in the compressed condition and the retraction member in the extended condition to retain the prosthesis. In a deployment state, the sheath end is positioned to permit the release member to self-transition to the expanded condition, allowing the retraction member to self-transition to the retracted condition and release the prosthesis.

Abstract translation: 用于经皮部署假性瓣膜的输送装置包括护套，内轴和释放组件。 释放组件设置在护套和内轴之间，并且包括缩回构件，释放构件和保持构件。 缩回构件可以从伸长状态自动缩回到缩回状态。 释放构件可以从压缩状态自膨胀到膨胀状态。 保持构件远离释放构件。 在输送状态下，护套端部处于保持构件的远侧，释放构件处于压缩状态，并且延伸构件处于延伸状态以保持假体。 在展开状态中，护套端部被定位成允许释放构件自我转变到扩张状态，允许收回构件自我转变到缩回状态并释放假体。

公开(公告)号：US20150196391A1

公开(公告)日：2015-07-16

申请号：US14155772

申请日：2014-01-15

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61B50/30 ,  A61B50/33 ,  A61B2017/00084 ,  A61M25/002

Abstract: A tray for loading a medical device on a catheter assembly includes a reservoir and a temperature sensing and indicating device disposed in the reservoir. The reservoir is defined by a bottom surface, a first wall, a second wall, a third wall, and a fourth wall, and includes an open top opposite the bottom surface. The reservoir configured to receive a liquid such that a medical device may be loaded onto a catheter assembly while submerged in the liquid. The temperature sensing and indicating device senses the temperature of the liquid in the reservoir and indicates to the user when the liquid is at a desired temperature for loading the medical device onto the catheter assembly.

Abstract translation: 用于将医疗装置装载在导管组件上的托盘包括储存器和设置在储存器中的温度检测和指示装置。 储存器由底表面，第一壁，第二壁，第三壁和第四壁限定，并且包括与底表面相对的开口顶部。 储存器构造成接收液体，使得医疗装置可以在浸没在液体中的同时被装载到导管组件上。 温度检测和指示装置感测储存器中的液体的温度，并且向用户指示当液体处于用于将医疗装置装载到导管组件上的期望温度时。

公开(公告)号：US20140114408A1

公开(公告)日：2014-04-24

申请号：US13658044

申请日：2012-10-23

Applicant: MEDTRONIC, INC.

Inventor： Joshua Dwork

IPC: A61F2/24 ,  B21D51/16

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2230/0013 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10T29/49405

Abstract: A heart valve prosthesis and delivery systems are provided for replacing a cardiac valve. The heart valve prosthesis includes a self-expanding frame includes a portion having a crimp that provides additional flexibility to the self-expanding frame in the collapsed configuration.

Abstract translation: 提供心脏瓣膜假体和输送系统以更换心脏瓣膜。 心脏瓣膜假体包括自扩张框架，其包括具有卷曲的部分，其在折叠构型中为自扩张框架提供额外的灵活性。

公开(公告)号：US20130204356A1

公开(公告)日：2013-08-08

申请号：US13792777

申请日：2013-03-11

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Patrick E. Macaulay ,  Gianfranco M. Pellegrini ,  Finn O. Rinne ,  Richard Spork ,  Don Huy Tran ,  Nathan B. Wiemeyer

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2412

Abstract: Delivery devices and methods for percutaneously delivering a prosthetic valve to the heart of a patient. These prosthetic valves may be configured to provide complimentary features that promote optimal placement of the prosthetic valve in a native heart valve, such as the aortic valve, mitral valve, pulmonic valve, and/or tricuspid valve. The delivery device includes a release sheath assembly housed within an outer delivery sheath. A release sheath component of the assembly captures a portion of the prosthetic valve to the delivery device, and effectuates complete release of the prosthetic valve with retraction of the outer sheath.

Abstract translation: 用于经皮递送假体瓣膜至患者心脏的输送装置和方法。 这些假体瓣膜可被构造成提供促进人造瓣膜在天然心脏瓣膜（例如主动脉瓣，二尖瓣，肺静脉瓣和/或三尖瓣）中的最佳放置的互补特征。 输送装置包括容纳在外部输送护套内的释放护套组件。 组件的释放护套部件将一部分人工瓣膜捕获到输送装置，并通过外护套的缩回来实现人造瓣膜的完全释放。

公开(公告)号：US11278402B2

公开(公告)日：2022-03-22

申请号：US16794441

申请日：2020-02-19

Applicant: MEDTRONIC, INC.

Inventor： John Morriss ,  Joshua Dwork ,  Nathaniel Piland ,  Finn Rinne ,  David Grossman

IPC: A61F2/24 ,  A61B17/00 ,  A61F2/07

Abstract: A prosthesis having a radially expanded configuration and a radially compressed configuration includes a frame with a plurality of infolding longitudinal segments. Each of the infolding longitudinal segments of the frame extend an entire length of the frame and is configured to deform radially inward when the prosthesis is in the radially compressed configuration such that a series of longitudinally aligned apices of each infolding longitudinal segment is disposed radially inward of the remainder of the prosthesis. In an embodiment, the frame also includes a plurality of outfolding longitudinal segments. Each of the outfolding longitudinal segments of the frame extend an entire length of the frame and is configured to deform radially outward when the prosthesis is in the radially compressed configuration such that a series of longitudinally aligned apices of each outfolding longitudinal segment is disposed radially outward of the remainder of the prosthesis.

公开(公告)号：US20190254818A1

公开(公告)日：2019-08-22

申请号：US16403769

申请日：2019-05-06

Applicant: Medtronic, Inc.

Inventor： Jason Quill ,  Padraig Savage ,  Joshua Dwork ,  Kshitija Garde ,  Sarah Ahlberg ,  Igor Kovalsky

IPC: A61F2/24

Abstract: Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.

公开(公告)号：US09662238B2

公开(公告)日：2017-05-30

申请号：US14503522

申请日：2014-10-01

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Hubert Yeung ,  Adam Shipley

IPC: A61F2/95 ,  A61F2/966

CPC classification number: A61F2/966 ,  A61F2/95 ,  A61F2002/9505

Abstract: An attachment mechanism for coupling a stent to a delivery system is disclosed. The attachment mechanism is configured to pivot relative to an inner shaft assembly of the delivery system in order to release the stent from the delivery system. Methods of deploying the stent with the delivery system are also disclosed.

公开(公告)号：US20150025624A1

公开(公告)日：2015-01-22

申请号：US14505694

申请日：2014-10-03

Applicant: Medtronic, Inc.

Inventor： Joshua Dwork ,  Glenn Stante ,  Adam Shipley

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2002/9505 ,  A61F2230/0054 ,  A61F2230/008

Abstract: A delivery device for percutaneously deploying a prosthetic valve includes a sheath, an inner shaft, and a release assembly. The release assembly is disposed between the sheath and the inner shaft, and includes a retraction member, a release member, and a retention member. The retraction member can self-retract in length from an extended condition to a retracted condition. The release member can self-expand from a compressed condition to an expanded condition. The retention member is distal the release member. In a delivery state, the sheath end is distal the retention member, the release member is in the compressed condition and the retraction member in the extended condition to retain the prosthesis. In a deployment state, the sheath end is positioned to permit the release member to self-transition to the expanded condition, allowing the retraction member to self-transition to the retracted condition and release the prosthesis.

Abstract translation: 用于经皮部署假性瓣膜的输送装置包括护套，内轴和释放组件。 释放组件设置在护套和内轴之间，并且包括缩回构件，释放构件和保持构件。 缩回构件可以从伸长状态自动缩回到缩回状态。 释放构件可以从压缩状态自膨胀到膨胀状态。 保持构件远离释放构件。 在输送状态下，护套端部处于保持构件的远侧，释放构件处于压缩状态，并且延伸构件处于延伸状态以保持假体。 在展开状态中，护套端部被定位成允许释放构件自我转变到扩张状态，允许收回构件自我转变到缩回状态并释放假体。