公开(公告)号：US20140088659A1

公开(公告)日：2014-03-27

申请号：US13626988

申请日：2012-09-26

Applicant: MEDTRONIC, INC.

Inventor： Randolph E. Crutchfield ,  Lonny V. Cabelka ,  Mark R. Boone ,  Marshall J. Rasmussen

IPC: A61N1/39

CPC classification number: A61N1/3981 ,  A61N1/371 ,  A61N1/3906 ,  A61N1/3956 ,  A61N1/3987

Abstract: The disclosure relates to an apparatus and method for inducing ventricular fibrillation in a patient to facilitate defibrillation threshold testing. The apparatus includes a plurality of output capacitors that are dynamically configurable in a selected stacking arrangement that facilitates delivery of energy for inducing the ventricular fibrillation. An output of the apparatus is coupled to patient electrodes and a threshold energy level delivered by the output capacitors is determined

Abstract translation: 本公开涉及一种用于诱导患者心室颤动的装置和方法，以促进除颤阈值测试。 该装置包括多个输出电容器，其可以以选择的堆叠布置动态地配置，这有助于输送用于诱导心室颤动的能量。 设备的输出耦合到患者电极，并确定由输出电容器传递的阈值能量水平

公开(公告)号：US20160339260A1

公开(公告)日：2016-11-24

申请号：US14717773

申请日：2015-05-20

Applicant: Medtronic, Inc.

Inventor： Marshall J. Rasmussen ,  Lonny V. Cabelka ,  Randolph E. Crutchfield

IPC: A61N1/39

CPC classification number: A61N1/3987 ,  A61N1/36142 ,  A61N1/37 ,  A61N1/3937 ,  A61N1/3956 ,  A61N1/3975

Abstract: An implantable medical device includes a housing, a power source and an operational circuit that is coupled to the power source. The operational circuit includes a first electrode terminal and a second electrode terminal, an output circuit configured to deliver an electrical stimulation therapy through the first and second electrode terminals and a control circuit configured to evaluate an electrical parameter associated with the output circuit and to control generation of the electrical stimulation therapy responsive to a result of the evaluated parameter. Among other things, the implantable medical device may modify a parameter of the therapy delivery in response to a result of the evaluation.

Abstract translation: 可植入医疗装置包括壳体，电源和耦合到电源的操作电路。 所述操作电路包括第一电极端子和第二电极端子，所述输出电路经配置以通过所述第一和第二电极端子传送电刺激治疗;以及控制电路，被配置为评估与所述输出电路相关联的电参数并控制发电 的电刺激治疗响应于评估参数的结果。 除此之外，可植入医疗装置可以响应于评估结果来修改治疗递送的参数。

公开(公告)号：US20160067509A1

公开(公告)日：2016-03-10

申请号：US14695630

申请日：2015-04-24

Applicant: Medtronic, Inc.

Inventor： John T. Meador ,  Randolph E. Crutchfield ,  Mark R. Boone ,  Lonny V. Cabelka

IPC: A61N1/39

CPC classification number: A61N1/3975 ,  A61N1/3925 ,  A61N1/3956

Abstract: An implantable medical device includes a low-power circuit, a high-power circuit, and a dual-cell power source. The power source is coupled to a transformer having first and second primary windings, each of which is selectively coupled to the power source and a plurality of secondary windings that are magnetically coupled to the first and second primary windings. The plurality of secondary windings are interlaced along a length of each of the secondary windings. Each of the plurality of secondary transformer windings is coupled to a capacitor, and the capacitors are all connected in a series configuration. The low power circuit is coupled to the power source and issues a control signal to control the delivery of charge from the power source to the plurality of capacitors through the first and second transformers.

Abstract translation: 可植入医疗装置包括低功率电路，高功率电路和双电池电源。 电源耦合到具有第一和第二初级绕组的变压器，每个初级绕组选择性地耦合到电源和多个次级绕组，其被磁耦合到第一和第二初级绕组。 多个次级绕组沿着每个次级绕组的长度交织。 多个次级变压器绕组中的每一个耦合到电容器，并且电容器都以串联配置连接。 低功率电路耦合到电源并且发出控制信号以控制通过第一和第二变压器从电源向多个电容器传送电荷。

公开(公告)号：US20150306406A1

公开(公告)日：2015-10-29

申请号：US14260309

申请日：2014-04-24

Applicant: Medtronic, Inc.

Inventor： Randolph E. Crutchfield ,  Lonny V. Cabelka ,  Mark R. Boone ,  Kevin P. Kuehn ,  Marshall J. Rasmussen

IPC: A61N1/38 ,  A61N1/39

CPC classification number: A61N1/385 ,  A61N1/0587 ,  A61N1/362 ,  A61N1/3706 ,  A61N1/3912 ,  A61N1/3925 ,  A61N1/3956 ,  A61N1/3962 ,  A61N1/3975

Abstract: Apparatus and methods for generating an induction waveform for performing threshold testing in an implantable medical device are disclosed. Such tests may be performed during the implant procedure, or during a device checkup procedure, or routinely during the lifetime of the device. The threshold test may include induction of an arrhythmia (such as ventricular fibrillation) followed by delivery of therapy at various progressively-increasing stimulation parameters to terminate the arrhythmia. As such, the capability to induce fibrillation within the device is desired. Induction of the arrhythmias may be accomplished via delivery of a relatively low energy shock or through delivery of an induction stimulation pulse to the cardiac tissue timed concurrently with the vulnerable period of the cardiac cycle.

Abstract translation: 公开了用于产生用于在可植入医疗装置中进行阈值测试的感应波形的装置和方法。 这样的测试可以在植入过程期间，或者在设备检查过程期间，或者在设备的寿命期间常规地执行。 阈值测试可以包括诱导心律失常（例如心室颤动），随后以各种逐渐增加的刺激参数递送治疗以终止心律失常。 因此，期望在装置内诱导原纤维化的能力。 心律不齐的诱导可以通过递送相对低的能量冲击或通过将感应刺激脉冲递送到与心动周期的脆弱时段同时定时的心脏组织来实现。

公开(公告)号：US09168379B2

公开(公告)日：2015-10-27

申请号：US13626970

申请日：2012-09-26

Applicant: Medtronic, Inc.

Inventor： Lonny V. Cabelka ,  Randolph E. Crutchfield ,  Mark R. Boone ,  Marshall J. Rasmussen

IPC: A61N1/362 ,  A61N1/39 ,  A61N1/37

CPC classification number: A61N1/362 ,  A61N1/371 ,  A61N1/3981 ,  A61N1/3987

Abstract: Recent advancements in power electronics technology have provided opportunities for enhancements to implantable medical device circuits. The enhancements have contributed to increasing circuit miniaturization and increased efficiency in the operation of the implantable medical devices. Stimulation therapy waveforms generated by the circuits include a stepped leading-edge that may be shaped having a varying slope and varying amplitudes associated with each of the segments of the slope. A charging circuit having a single primary transformer winding and a single secondary transformer winding that is coupled to a plurality of capacitors is utilized to generate the therapy stimulation waveforms. The stimulation waveform of the present disclosure may be dynamically shaped as a function of an individual patient's response. Such stimulation waveforms facilitate achieving lower capture thresholds which reduces the device's supply consumption thereby increasing longevity of the device and facilitate a reduction of tissue damage.

Abstract translation: 电力电子技术的最新进展为植入式医疗器械电路的增强提供了机会。 这些增强有助于增加电路小型化并提高可植入医疗装置的操作效率。 由电路产生的刺激治疗波形包括阶梯式前缘，其可以被成形为具有与斜率的每个段相关联的变化的斜率和变化的幅度。 使用具有单个一次变压器绕组和耦合到多个电容器的单个次级变压器绕组的充电电路来产生治疗刺激波形。 本公开的刺激波形可以根据个体患者的反应而动态地形成。 这种刺激波形有助于实现较低的捕获阈值，这降低了装置的供应消耗，从而增加了装置的使用寿命并促进了组织损伤的减少。

公开(公告)号：US08532785B1

公开(公告)日：2013-09-10

申请号：US13626977

申请日：2012-09-26

Applicant: Medtronic, Inc.

Inventor： Randolph E. Crutchfield ,  Lonny V. Cabelka ,  Mark R. Boone ,  Marshall J. Rasmussen

IPC: A61N1/00

CPC classification number: A61N1/3981

Abstract: Recent advancements in power electronics technology have provided opportunities for enhancements to circuits of implantable medical devices. The enhancements have contributed to increasing circuit miniaturization and an increased efficiency in the operation of the implantable medical devices. The therapy delivery circuits and techniques of the disclosure facilitate generation of a therapy stimulation waveform that may be shaped based on the patient's physiological response to the stimulation waveform. The generated therapy stimulation waveforms include a stepped leading-edge that may be shaped having a varying slope and varying amplitudes associated with each of the segments of the slope. Unlike the truncated exponential waveform delivered by the conventional therapy delivery circuit which is based on the behavior of the output capacitors (i.e., i=C(dV/dt)), the stimulation waveform of the present disclosure may be dynamically shaped as a function of an individual patient's response. The dynamically shaped therapy stimulation waveforms facilitate achieving lower capture thresholds which reduces the device's supply consumption thereby increasing longevity of the device and facilitate a reduction of tissue damage.

Abstract translation: 电力电子技术的最新进展为植入式医疗器械电路的增强提供了机会。 这些增强功能有助于增加电路小型化并提高可植入医疗装置的操作效率。 本公开的治疗递送电路和技术有助于产生可以基于患者对刺激波形的生理反应而变形的治疗刺激波形。 产生的治疗刺激波形包括阶梯形前缘，其可以被成形为具有与斜率的每个段相关联的变化的斜率和变化的幅度。 与基于输出电容器的行为（即，i = C（dV / dt））的传统治疗传递电路传递的截断指数波形不同，本公开的刺激波形可以动态地形成为 个人病人的反应。 动态形状的治疗刺激波形有助于实现更低的捕获阈值，这降低了装置的供应消耗，从而增加了装置的使用寿命，并有助于减少组织损伤。

公开(公告)号：US09956422B2

公开(公告)日：2018-05-01

申请号：US14260309

申请日：2014-04-24

Applicant: Medtronic, Inc.

Inventor： Randolph E. Crutchfield ,  Lonny V. Cabelka ,  Mark R. Boone ,  Kevin P. Kuehn ,  Marshall J. Rasmussen

IPC: A61N1/39 ,  A61N1/38 ,  A61N1/362 ,  A61N1/37 ,  A61N1/05

CPC classification number: A61N1/385 ,  A61N1/0587 ,  A61N1/362 ,  A61N1/3706 ,  A61N1/3912 ,  A61N1/3925 ,  A61N1/3956 ,  A61N1/3962 ,  A61N1/3975

Abstract: Apparatus and methods for generating an induction waveform for performing threshold testing in an implantable medical device are disclosed. Such tests may be performed during the implant procedure, or during a device checkup procedure, or routinely during the lifetime of the device. The threshold test may include induction of an arrhythmia (such as ventricular fibrillation) followed by delivery of therapy at various progressively-increasing stimulation parameters to terminate the arrhythmia. As such, the capability to induce fibrillation within the device is desired. Induction of the arrhythmias may be accomplished via delivery of a relatively low energy shock or through delivery of an induction stimulation pulse to the cardiac tissue timed concurrently with the vulnerable period of the cardiac cycle.

公开(公告)号：US20160067513A1

公开(公告)日：2016-03-10

申请号：US14695948

申请日：2015-04-24

Applicant: Medtronic, Inc.

Inventor： Randolph E. Crutchfield ,  Mark R. Boone ,  Lonny V. Cabelka ,  Kevin P. Kuehn ,  John T. Meador ,  John D. Norton ,  Craig L. Schmidt

IPC: A61N1/39

CPC classification number: A61N1/3975 ,  A61N1/378 ,  A61N1/3782 ,  A61N1/3931 ,  A61N1/3956 ,  A61N1/3981

Abstract: An implantable medical device includes a low-power circuit and a multi-cell power source. The cells of the power source are coupled in a parallel configuration. The implantable medical device includes both a low power circuit that is selectively coupled between the first and second cells and a high power output circuit that is directly coupled to the first and second cells in a parallel configuration. An isolation circuit is coupled to the first cell, the second cell and the low power circuit to maintain a current isolation between the first cell and the second cell at least during delivery currents having a large magnitude that are delivered to the high power output circuit.

Abstract translation: 可植入医疗装置包括低功率电路和多电池电源。 电源的电池以并联结构耦合。 可植入医疗装置包括选择性地耦合在第一和第二小室之间的低功率电路和以并联配置直接耦合到第一和第二小区的高功率输出电路。 隔离电路耦合到第一单元，第二单元和低功率电路，以至少在传递到大功率输出电路的大幅度的传输电流期间，保持第一单元和第二单元之间的电流隔离。

公开(公告)号：US20160067506A1

公开(公告)日：2016-03-10

申请号：US14695264

申请日：2015-04-24

Applicant: Medtronic, Inc.

Inventor： Randolph E. Crutchfield ,  Mark R. Boone ,  Lonny V. Cabelka ,  John T. Meador

IPC: A61N1/39 ,  H02J7/00

CPC classification number: A61N1/3975 ,  A61N1/3782 ,  A61N1/3956 ,  H02J7/0021 ,  H02J7/007

Abstract: An implantable medical device includes a low-power circuit and a multi-cell power source. The cells of the power source are coupled to a transformer in a parallel configuration. The transformer includes multiple secondary windings and each of the windings is coupled to a capacitor that stores energy for delivery of a therapy to a patient. In accordance with embodiments of this disclosure, the low power circuit is configured to control simultaneous delivery of energy from each of the cells to a plurality of capacitors through the transformer.

Abstract translation: 可植入医疗装置包括低功率电路和多电池电源。 电源的单元以并联结构耦合到变压器。 变压器包括多个次级绕组，并且每个绕组耦合到电容器，该电容器存储用于向患者递送治疗的能量。 根据本公开的实施例，低功率电路被配置为控制通过变压器同时从每个小区到多个电容器的能量传递。

公开(公告)号：US20140088656A1

公开(公告)日：2014-03-27

申请号：US13626970

申请日：2012-09-26

Applicant: MEDTRONIC, INC.

Inventor： Lonny V. Cabelka ,  Randolph E. Crutchfield ,  Mark R. Boone ,  Marshall J. Rasmussen

IPC: A61N1/378

CPC classification number: A61N1/362 ,  A61N1/371 ,  A61N1/3981 ,  A61N1/3987

Abstract: Recent advancements in power electronics technology have provided opportunities for enhancements to implantable medical device circuits. The enhancements have contributed to increasing circuit miniaturization and increased efficiency in the operation of the implantable medical devices. Stimulation therapy waveforms generated by the circuits include a stepped leading-edge that may be shaped having a varying slope and varying amplitudes associated with each of the segments of the slope. A charging circuit having a single primary transformer winding and a single secondary transformer winding that is coupled to a plurality of capacitors is utilized to generate the therapy stimulation waveforms. The stimulation waveform of the present disclosure may be dynamically shaped as a function of an individual patient's response. Such stimulation waveforms facilitate achieving lower capture thresholds which reduces the device's supply consumption thereby increasing longevity of the device and facilitate a reduction of tissue damage.

Abstract translation: 电力电子技术的最新进展为植入式医疗器械电路的增强提供了机会。 这些增强有助于增加电路小型化并提高可植入医疗装置的操作效率。 由电路产生的刺激治疗波形包括阶梯式前缘，其可以被成形为具有与斜率的每个段相关联的变化的斜率和变化的幅度。 使用具有单个一次变压器绕组和耦合到多个电容器的单个次级变压器绕组的充电电路来产生治疗刺激波形。 本公开的刺激波形可以根据个体患者的反应而动态地形成。 这种刺激波形有助于实现较低的捕获阈值，这降低了装置的供应消耗，从而增加了装置的使用寿命并促进了组织损伤的减少。