公开(公告)号：US20130103161A1

公开(公告)日：2013-04-25

申请号：US13656163

申请日：2012-10-19

申请人： Medtronic Vascular, Inc.

发明人： Ya Guo ,  Joseph Berglund ,  Christopher W. Storment ,  James W. Wright

IPC分类号： A61F2/82

CPC分类号： A61L31/022 ,  A61L31/148

摘要： A stent includes an iron-based alloy that consists essentially of: Fe—X—Y, wherein X is at least one austenite stabilizing element selected from the group consisting of Co, Ni, Mn, Cu, Re, Rh, Ru, Ir, Pt, Pd, C, and N, and wherein Y is at least one corrosion-activator species selected from the group consisting of Au, and Pd.

摘要翻译： 支架包括基本上由以下组成的铁基合金：Fe-XY，其中X是选自Co，Ni，Mn，Cu，Re，Rh，Ru，Ir，Pt中的至少一种奥氏体稳定元素， Pd，C和N，并且其中Y是至少一种选自Au和Pd的腐蚀活化剂。

公开(公告)号：US10888408B2

公开(公告)日：2021-01-12

申请号：US15968847

申请日：2018-05-02

申请人： Medtronic Vascular, Inc.

发明人： Raymond Ryan ,  David Clarke ,  Kshitija Garde ,  Ya Guo ,  Benjamin Wong ,  Yogesh Darekar ,  Luke Lehmann ,  Wei Wang ,  Laura McKinley ,  Paul Devereux ,  Joshua Dudney ,  Tracey Tien ,  Karl Olney

IPC分类号： A61F2/00 ,  B65D81/22 ,  B65D81/18 ,  A61F2/24 ,  A61L2/26 ,  A61L2/20 ,  A61L2/08

摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

公开(公告)号：US10463512B2

公开(公告)日：2019-11-05

申请号：US15376398

申请日：2016-12-12

申请人： Medtronic Vascular, Inc.

发明人： Justin Peterson ,  James Mitchell ,  Abby S Pandya ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： A61F2/91 ,  A61L31/16 ,  A61F2/82

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

公开(公告)号：US20160215372A1

公开(公告)日：2016-07-28

申请号：US15006885

申请日：2016-01-26

申请人： Medtronic Vascular, Inc.

发明人： Syamala Rani Pulugurtha ,  Jeffrey Allen ,  Ya Guo

IPC分类号： C22C23/06

CPC分类号： C22C23/06

摘要： A magnesium alloy includes a rare earth element alloy component comprising yttrium, a rare earth element (REE) other than yttrium, and a balance of magnesium. The rare earth element other than yttrium may comprise two or more rare earth elements other than yttrium. The rare earth element other than yttrium may include a heavy rare earth element and a light rare earth element. The alloy may include about 4-10 wt-% yttrium, 0-9 wt-% heavy REE, 0-7 wt-% light REE, 0-7 wt-% zinc, 0-0.7 wt-% zirconium, and a balance of magnesium. The balance of magnesium may be in an amount up to 90 wt-%.

摘要翻译： 镁合金包括含有钇的稀土元素合金成分，除了钇之外的稀土元素（REE），余量为镁。 除了钇之外的稀土元素可以包括除了钇之外的两种或更多种稀土元素。 除了钇之外的稀土元素可以包括重稀土元素和轻稀土元素。 合金可以包括约4-10重量％的钇，0-9重量％的重REE，0-7重量％的轻REE，0-7重量％的锌，0-0.7重量％的锆，余量 的镁。 镁的余量可以达到90重量％以上。

公开(公告)号：US20130090741A1

公开(公告)日：2013-04-11

申请号：US13645229

申请日：2012-10-04

申请人： Medtronic Vascular, Inc.

发明人： Ya Guo ,  Abhijeet Misra ,  James W. Wright ,  Joseph Berglund ,  Rajesh Prasannavenkatesan

IPC分类号： A61F2/04

CPC分类号： A61L31/022 ,  A61L31/148

摘要： A stent is formed from a magnesium alloy that consists essentially of: 0-10 weight % rare earth element; 0-5 weight % Li; 0-1 weight % Mn; 0-1 weight % Zr; and balance Mg, or the stent is formed from a magnesium alloy that consists essentially of: 0-5 weight % rare earth element; 0-8 weight % Li; 0-1 weight % Mn; 0-1 weight % Sn; 0-3 weight % Al; 0-4 weight % Zn; and balance Mg.

摘要翻译： 支架由镁合金形成，镁合金基本上由0-10重量％的稀土元素构成; 0-5重量％Li; 0-1重量％Mn; 0-1重量％Zr; 并且平衡Mg，或者支架由基本上由以下组成的镁合金形成：0-5重量％的稀土元素; 0-8重量％Li; 0-1重量％Mn; 0-1重量％Sn; 0-3重量％Al; 0-4重量％Zn; 并平衡Mg。