-
公开(公告)号：US11344399B2
公开(公告)日：2022-05-31
申请号：US17115205
申请日：2020-12-08
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
-
公开(公告)号：US20210113320A1
公开(公告)日：2021-04-22
申请号：US17115205
申请日：2020-12-08
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
-
公开(公告)号：US20180318060A1
公开(公告)日：2018-11-08
申请号：US15968847
申请日：2018-05-02
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61L2/206 , B65D81/18 , B65D81/22
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
-
公开(公告)号：US20220257360A1
公开(公告)日：2022-08-18
申请号：US17735248
申请日：2022-05-03
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
-
公开(公告)号：US20200000962A1
公开(公告)日：2020-01-02
申请号：US16453717
申请日：2019-06-26
发明人： Hamed Alavi , Ya Guo
摘要： Load bearing crowded collagen material for use in engineered tissue may be formed by crowding collagen fibrils. The crowding may be performed by dialysis. The fibrils may be formed by neutralizing an acidic solution comprising collagen monomers.
-
公开(公告)号：US20170086996A1
公开(公告)日：2017-03-30
申请号：US15376398
申请日：2016-12-12
发明人： Justin Peterson , James Mitchell , Abby S. Pandya , Nate Glucklich , Joseph Berglund , Ya Guo
摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.
-
公开(公告)号：US09155637B2
公开(公告)日：2015-10-13
申请号：US13800121
申请日：2013-03-13
CPC分类号： A61F2/82 , A61L31/022 , A61L31/10 , A61L31/14 , A61L31/148 , C08L67/04 , C08L75/04 , C08L33/10
摘要： A stent includes a bioabsorbable metal, a hydrothermal conversion film covering the bioabsorbable metal, and a coating covering the hydrothermal conversion film. A method for manufacturing a stent includes forming a stent body comprising a bioabsorbable metal, forming a hydrothermal conversion film over surfaces of the stent body, and coating the hydrothermal conversion film with an overcoat.
摘要翻译： 支架包括生物可吸收金属，覆盖生物可吸收金属的水热转化膜和覆盖水热转换膜的涂层。 支架的制造方法包括：形成包含生物体吸收性金属的支架主体，在所述支架主体的表面上形成水热转换膜，以及涂覆所述水热转换膜。
-
公开(公告)号：US11969329B2
公开(公告)日：2024-04-30
申请号：US17735248
申请日：2022-05-03
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
CPC分类号： A61F2/0095 , A61F2/2412 , A61L2/206 , A61L2/26 , B65D81/18 , B65D81/22 , A61F2/2418 , A61L2/08 , A61L2/208 , A61L2202/182 , A61L2202/21
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
-
公开(公告)号：US20170173214A1
公开(公告)日：2017-06-22
申请号：US14976092
申请日：2015-12-21
发明人： Wei Wang , Kshitija Garde , Ya Guo , Benjamin Wong , Laura McKinley , Tracey Tien
CPC分类号： A61L27/3687 , A61L27/3625 , A61L27/3683 , A61L27/3691 , A61L27/505 , A61L31/005 , A61L2430/20 , A61L2430/40
摘要： A method of preparing dry cross-linked biological tissue. A processing solution is prepared that contains a cross-linking agent and an organic water-soluble liquid. Biological tissue is immersed in the processing solution for an effective period of time to substantially displace water from the biological tissue and substantially cross-link the biological tissue to form dry cross-linked biological tissue.
-
公开(公告)号：US20140277396A1
公开(公告)日：2014-09-18
申请号：US13800121
申请日：2013-03-13
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61L31/022 , A61L31/10 , A61L31/14 , A61L31/148 , C08L67/04 , C08L75/04 , C08L33/10
摘要： A stent includes a bioabsorbable metal, a hydrothermal conversion film covering the bioabsorbable metal, and a coating covering the hydrothermal conversion film. A method for manufacturing a stent includes forming a stent body comprising a bioabsorbable metal, forming a hydrothermal conversion film over surfaces of the stent body, and coating the hydrothermal conversion film with an overcoat.
摘要翻译： 支架包括生物可吸收金属，覆盖生物可吸收金属的水热转化膜和覆盖水热转换膜的涂层。 支架的制造方法包括：形成包含生物体吸收性金属的支架主体，在所述支架主体的表面上形成水热转换膜，以及涂覆所述水热转换膜。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.014 秒)
