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公开(公告)号：US10660746B2
公开(公告)日：2020-05-26
申请号：US16123047
申请日：2018-09-06
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US10092398B2
公开(公告)日：2018-10-09
申请号：US14990657
申请日：2016-01-07
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US20170196684A1
公开(公告)日：2017-07-13
申请号：US14990657
申请日：2016-01-07
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2002/9522 , B65B63/02 , B65B63/08
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US11766325B2
公开(公告)日：2023-09-26
申请号：US17747292
申请日：2022-05-18
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2/9525 , B65B63/02 , B65B63/08 , A61F2/9522
摘要： Devices for, and methods of, compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US11364115B2
公开(公告)日：2022-06-21
申请号：US16854095
申请日：2020-04-21
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US10888408B2
公开(公告)日：2021-01-12
申请号：US15968847
申请日：2018-05-02
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
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公开(公告)号：US20190038402A1
公开(公告)日：2019-02-07
申请号：US16123047
申请日：2018-09-06
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2002/9522 , B65B63/02 , B65B63/08
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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公开(公告)号：US20220257360A1
公开(公告)日：2022-08-18
申请号：US17735248
申请日：2022-05-03
发明人： Raymond Ryan , David Clarke , Kshitija Garde , Ya Guo , Benjamin Wong , Yogesh Darekar , Luke Lehmann , Wei Wang , Laura McKinley , Paul Devereux , Joshua Dudney , Tracey Tien , Karl Olney
摘要： A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.
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公开(公告)号：US20200246138A1
公开(公告)日：2020-08-06
申请号：US16854095
申请日：2020-04-21
发明人： Wei Wang , Benjamin Wong , Laura McKinley , Joshua Dudney , Tracey Tien , Karl Olney
摘要： Methods of compressing a stented prosthetic heart valve are disclosed. The method including inserting a stented prosthetic heart valve having a self-expandable stent frame into a container, initiating a cooling element in the container, transferring heat through a thermal conductor to cool an interior of the container, reducing a temperature of the self-expandable stent frame while located within the container to a critical temperature of not greater than 8° C., and compressing an outer diameter of the stented prosthetic heart valve while the stented prosthetic heart valve is at the critical temperature.
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10.发明申请TRANSCATHETER VALVE PROSTHESES HAVING A SEALING COMPONENT FORMED FROM TISSUE HAVING AN ALTERED EXTRACELLULAR MATRIX 审中-公开具有由具有改变的细胞基质的组织形成的密封组件的转运阀公开(公告)号：US20170056164A1
公开(公告)日：2017-03-02
申请号：US14843128
申请日：2015-09-02
发明人： Wei Wang , Laura McKinley , Benjamin Wong , Karl Olney , Tracey Tien
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/844 , A61F2210/0061 , A61F2250/0024 , A61F2250/0031 , A61F2250/0056 , A61F2250/0069
摘要： A transcatheter valve prosthesis including a sealing component formed from a tissue having an altered extracellular matrix. The altered extracellular matrix includes at least one weakened connection such that the tissue is configured to swell or expand upon contact with a fluid. The altered extracellular matrix does not reduce compressibility of the tissue such that the delivery profile of the transcatheter valve prosthesis is not adversely affected. The tissue having an altered extracellular matrix transforms from a compressed state for delivery within a vasculature to an expanded state in situ when blood infiltrates or flows within the at least one weakened connection. The sealing component in the expanded state conforms to the geometry of the native valve tissue, thereby preventing paravalvular leakage at the implantation site.
摘要翻译： 一种经导管瓣膜假体，其包括由具有改变的细胞外基质的组织形成的密封组件。 改变的细胞外基质包括至少一个弱化的连接，使得组织构造成在与流体接触时膨胀或膨胀。 改变的细胞外基质不会降低组织的压缩性，使得经导管瓣膜假体的输送分布不受不利影响。 具有改变的细胞外基质的组织当血液渗入或流入至少一个弱化的连接内时，从压缩状态转换成脉管系统内的扩张状态。 处于膨胀状态的密封部件符合天然瓣膜组织的几何形状，从而防止植入部位的瓣膜溢出。
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