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11.发明申请Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050215596A1
公开(公告)日：2005-09-29
申请号：US10788997
申请日：2004-02-27
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , A61K31/422 , A61K31/4439 , A61P3/10 , A61P9/10 , C07D263/30 , C07D263/32 , C07D413/02 , C07D413/04
CPC分类号： C07D263/32 , C07D413/02
摘要： Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals
摘要翻译： 本文提供环烷基取代的氨基酸衍生物，其制备方法及其作为药物的用途
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12.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06642269B2
公开(公告)日：2003-11-04
申请号：US10201050
申请日：2002-07-24
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4，R 5和Z具有所示的含义，并且其生理上可耐受的盐 和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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13.发明授权Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use 有权二苯基氮杂环丁酮衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06498156B2
公开(公告)日：2002-12-24
申请号：US10021028
申请日：2001-12-19
申请人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schaefer
发明人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schaefer
IPC分类号： A61K31397
CPC分类号： C07D401/14 , C07D205/08 , C07D409/12
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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14.发明授权Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use 有权苯并（b）硫嘌呤-1,1-二氧化物衍生物，其制备方法，含有这些化合物的药物及其用途公开(公告)号：US06387944B1
公开(公告)日：2002-05-14
申请号：US09719047
申请日：2000-12-07
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07D337/08 , A61K38/00 , C07K5/06086 , C08G65/329 , Y02P20/55
摘要： The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and Z have the cited descriptions, to the physiologically compatible salts, to physiologically functional derivatives, and to a method for the production thereof. The compounds are suited, for example, as hypolipidemic agents.
摘要翻译： 本发明涉及取代的苯并（b）硫脲-1,1-二氧化物衍生物及其酸加成盐。 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和Z具有生理上相容的盐，生理功能衍生物，以及其生产方法。 该化合物适合于例如降血脂药。
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15.发明授权Propanolamine derivatives linked to bile acids, processes for their preparation, pharmaceuticals comprising these compounds, and their use 有权与胆汁酸连接的丙醇胺衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06180618B2
公开(公告)日：2001-01-30
申请号：US09408169
申请日：1999-09-29
IPC分类号： A61K3158
摘要： Compounds of formula (I) in which the radicals are as defined in the specification and claims, and physiologically tolerated and physiologically functional derivatives thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
摘要翻译： 描述了其中基团如说明书和权利要求书中所定义的式（I）化合物及其生理学耐受性和生理功能性衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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16.发明授权Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors 失效烯类不饱和胆汁酸衍生物，其制备方法和前体
公开(公告)号：US5559258A
公开(公告)日：1996-09-24
申请号：US345803
申请日：1994-11-22
申请人： Alfons Enhsen , Heiner Glombik , Stefan M ullner , G unther Wess
发明人： Alfons Enhsen , Heiner Glombik , Stefan M ullner , G unther Wess
CPC分类号： C07J9/005 , C07J31/006 , C07J41/0005 , C07J41/0011 , C07J41/0055 , C07J41/0088 , C07J41/0094 , C07J43/003 , C07J51/00
摘要： Ethylenically unsaturated bile acid derivatives of the formula IG--X--A Iin which G, X and A have the meanings indicated, are described. They are suitable for the preparation of polymeric bile acid derivatives. Bile acid derivatives of the formula IVaG--X' IVain which G and X' have the meanings indicated, are also described. They are useful synthesis components for the preparation of pharmaceuticals.
摘要翻译： 描述了其中G，X和A具有所示含义的式I G-X-A I的烯键式不饱和胆汁酸衍生物。 它们适用于制备聚合胆汁酸衍生物。 还描述了其中G和X'具有所示含义的式IVa G-X'IVa的胆汁酸衍生物。 它们是用于制备药物的有用的合成成分。
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17.发明授权Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments 失效非胆酸衍生物，其制备方法和这些化合物作为药物的用途
公开(公告)号：US5512558A
公开(公告)日：1996-04-30
申请号：US238514
申请日：1994-05-05
申请人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
发明人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
IPC分类号： A61K31/575 , A61P3/06 , A61P9/00 , C07J3/00 , C07J7/00 , C07J9/00 , C07J31/00 , C07J41/00 , C07J51/00 , A61K31/56 , C07J53/00
CPC分类号： C07J3/005 , C07J3/00 , C07J31/006 , C07J41/0005 , C07J41/0011 , C07J41/0027 , C07J41/0061 , C07J41/0066 , C07J41/0088 , C07J41/0094 , C07J51/00 , C07J7/0005 , C07J7/002 , C07J7/007 , C07J9/005
摘要： nor-Bile acid derivatives, processes for their preparation and the use of these compounds as medicaments nor-Bile acid derivatives of the formula IG1--X--G2 Iin which G1, G2 and X have the meanings given, processes for the preparation of these compounds and medicaments are described. On the basis of their pharmacological action, they can be used as an antihyperlipidemic agent.
摘要翻译： D-胆汁酸衍生物，其制备方法和这些化合物作为药物的用途，其中G1，G2和X具有给定的含义，式I G1-X-G2I的胆汁酸衍生物，其制备方法 描述了化合物和药物。 在其药理作用的基础上，可以用作抗高血脂药。
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18.发明授权Tetrazole derivatives of bile acids, and their use as lipid level lowering medicaments 失效胆汁酸的四唑衍生物及其作为降低脂质水平的药物的用途
公开(公告)号：US5466815A
公开(公告)日：1995-11-14
申请号：US238741
申请日：1994-05-05
申请人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
发明人： Alfons Enhsen , Heiner Glombik , Werner Kramer , Gunther Wess
IPC分类号： A61K31/575 , A61K31/58 , A61K31/675 , A61P3/06 , A61P9/10 , C07J9/00 , C07J17/00 , C07J41/00 , C07J43/00 , C07D257/06 , A61K31/41
CPC分类号： C07J9/005 , C07J17/00 , C07J41/0005 , C07J41/0094 , C07J43/003
摘要： The invention relates to tetrazole derivatives of bile acids, processes for their preparation, and use of these compounds as medicaments and cholesterol lowering agents. The tetrazole-bile acid derivatives are of the formula G1--X--G2, where G1 is H, a bile acid radical, or a bile acid radical which is modified on the hydroxyl functions and/or on the carboxyl group, X is a single bond or a bridge group between G1 and G2, and G2 is of the formula: ##STR1##
摘要翻译： 本发明涉及胆汁酸的四唑衍生物，其制备方法，以及这些化合物作为药物和降胆固醇剂的用途。 四唑 - 胆汁酸衍生物具有式G1-X-G2，其中G1是H，胆酸基或在羟基官能团和/或羧基上被修饰的胆汁酸基，X是单 键或G1和G2之间的桥组，G2是下式：
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19.发明授权Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07872034B2
公开(公告)日：2011-01-18
申请号：US12013806
申请日：2008-01-14
申请人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K31/421 , C07D263/32 , A61P3/10
CPC分类号： C07D263/32 , C07D413/02
摘要： The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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20.发明授权Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途公开(公告)号：US07772429B2
公开(公告)日：2010-08-10
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： C07C229/08 , C07C229/12
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译： 本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。
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