公开(公告)号：US20110207768A1

公开(公告)日：2011-08-25

申请号：US12722179

申请日：2010-03-11

Applicant: Michael Bornstein

Inventor： Michael Bornstein

IPC: A61K31/351 ,  A61K31/46 ,  A61K31/4164 ,  A61P31/04 ,  A61P31/10

CPC classification number: A61K45/06 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/351 ,  A61K31/4164 ,  A61K31/46 ,  A61K47/02 ,  A61K47/44 ,  A61K2300/00

Abstract: A method for the emperic treatment of an intertrigal skin infection potentially caused by a gram-positive bacteria in a human patient that includes a topical administration to the patient of a pharmaceutical formulation comprising a bactericidal amount of a Gram-positive bactericide and an antimycotic amount of an antifungal component suspended in a skin-barrier carrier.

Abstract translation: 一种用于经皮治疗由人类患者中的革兰氏阳性菌潜在引起的体内皮肤感染的方法，其包括向患者局部施用药物制剂，所述药物制剂包含杀菌量的革兰氏阳性杀菌剂和抗真菌剂量的 悬浮在皮肤屏障载体中的抗真菌组分。

公开(公告)号：US4002748A

公开(公告)日：1977-01-11

申请号：US650210

申请日：1976-01-19

Applicant: Michael Bornstein ,  Sandra M. Carone

Inventor： Michael Bornstein ,  Sandra M. Carone

IPC: A61K31/545 ,  C07D501/36 ,  A61K31/54

CPC classification number: A61K31/545

Abstract: Sterile, essentially amorphous cefazolin sodium for parenteral administration, having an improved solubility on reconstitution, is prepared by a freeze-drying process wherein a sterile solution of from about 10 to about 25 percent (W/V) of cefazolin sodium is exposed to an environment wherein the temperature is held at from about minus 50.degree. C. to minus 55.degree. C. until the temperature of the solution (frozen) is reduced to minus 48.degree. C. to minus 55.degree. C. before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.

Abstract translation: 通过冷冻干燥方法制备无菌的，用于肠胃外给药的无定形头孢唑啉钠，其具有改善的重建溶解性，其中约10至约25％（W / V）头孢唑啉钠的无菌溶液暴露于环境中 其中将温度保持在约零下50摄氏度至零下55摄氏度，直至将溶液（冷冻）的温度降低至零下至零下55摄氏度，然后将所述冷冻溶液置于高温 真空和适度的热量以使水从中升华。