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21 条记录 (耗时 0.03 秒)

    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
    11.
    发明授权
    Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs 有权
    用于治疗与苯丙胺类药物相关的医疗问题的单克隆抗体拮抗剂

    公开(公告)号：US06669937B2

    公开(公告)日：2003-12-30

    申请号：US09839549

    申请日：2001-04-20

    申请人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    发明人： Samuel M. Owens ,  Frank Ivy Carroll ,  Philip Abraham

    IPC分类号： A61K39395

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07B2200/07 ,  C07C217/60 ,  C07C233/18 ,  C07K2317/55

    摘要： The invention includes synthetic immunochemical haptens for the generation of antibodies, the antibodies, and the medical treatment applications for using the antibodies. The antibodies are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants, and will have insignificant cross-reactivity with endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses or fetus from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.

    摘要翻译： 本发明包括用于产生抗体的合成免疫化学半抗原，抗体和用于使用抗体的医疗治疗应用。 这些抗体被设计成识别出甲基苯丙胺类滥用兴奋剂的常见分子特征，并且将与内源底物（如多巴胺）或非处方药（例如1-甲基苯丙胺，伪麻黄碱，苯丙醇胺和 麻黄碱）。 这些单克隆抗体及其抗原结合片段可用于恢复吸毒成瘾者的急救室设置，以迅速逆转药物过量，保护胎儿或胎儿免受滥用怀孕母亲或精神病治疗的治疗计划，以减少恶化 兴奋剂引起的精神病。

    Method for making cocaine receptor binding ligands and intermediates therefor
    15.
    发明授权
    Method for making cocaine receptor binding ligands and intermediates therefor 失效
    制备可卡因受体结合配体及其中间体的方法

    公开(公告)号：US6123917A

    公开(公告)日：2000-09-26

    申请号：US509055

    申请日：1995-07-31

    申请人： Frank Ivy Carroll

    发明人： Frank Ivy Carroll

    IPC分类号： A61K51/04 ,  C07D451/02 ,  C07F7/08 ,  C07F7/22 ,  C07D401/00

    CPC分类号： C07D451/02 ,  A61K51/0448 ,  C07F7/0812 ,  C07F7/2212 ,  A61K2123/00

    摘要： An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a anhydroecgonine methyl ester appropriately substituted. The intermediate is prepared in high purity and can be directly converted to the binding ligand by iodine substitution.

    摘要翻译： 提供了一种制备可卡因受体结合配体的改进方法。 该方法要求制备由苯基三甲基硅烷和适当取代的脱氢gon根甲酯制备的甲硅烷基芳基中间体。 中间体以高纯度制备，可以通过碘取代直接转化成结合配体。

    Nicotinic receptor compounds
    19.
    发明授权
    Nicotinic receptor compounds 有权
    烟碱受体化合物

    公开(公告)号：US08981102B2

    公开(公告)日：2015-03-17

    申请号：US13817697

    申请日：2011-08-19

    申请人： Frank Ivy Carroll ,  Pauline Wanjiku Ondachi

    发明人： Frank Ivy Carroll ,  Pauline Wanjiku Ondachi

    IPC分类号： C07D401/00 ,  C07D409/14 ,  C07D487/08 ,  A61K31/407 ,  C07D401/14

    CPC分类号： C07D487/08 ,  A61K31/407 ,  C07D401/14 ,  C07D409/14

    摘要： Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.

    摘要翻译： 本文提供了能够作为烟碱受体的激动剂或拮抗剂起作用的化合物的化合物和方法。 还提供了包含一种或多种这些化合物的药物组合物，其可进一步包含一种或多种另外的治疗剂。 还提供了治疗可能对烟碱受体上的这种活性有反应的各种病症的方法，例如尼古丁依赖性。