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公开(公告)号：US20110065743A1
公开(公告)日：2011-03-17
申请号：US12911244
申请日：2010-10-25
申请人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/485 , C07D489/02 , C07D221/28 , A61K31/4748 , C07D471/18 , C07D211/18 , A61K31/451 , C07D401/12 , A61K31/453 , A61P25/00 , A61P9/10 , A61P3/04
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
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2.发明授权公开(公告)号：US07399762B2
公开(公告)日：2008-07-15
申请号：US11113158
申请日：2005-04-25
IPC分类号： A61K31/53 , A61K31/497 , A61K31/44
CPC分类号： C07D221/28 , C07D221/22 , C07D489/02
摘要： Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
摘要翻译： 提供了结构上新的阿片受体激动剂，以及这些激动剂在治疗慢性和/或急性疼痛中的用途。
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公开(公告)号：US08048895B2
公开(公告)日：2011-11-01
申请号：US12105814
申请日：2008-04-18
IPC分类号： A61K31/445 , C07D251/00 , C07D401/00 , C07D271/00 , C07D487/00
CPC分类号： A61K31/451 , A61K31/4725 , A61K31/485 , C07D401/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
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公开(公告)号：US07872023B2
公开(公告)日：2011-01-18
申请号：US11059390
申请日：2005-02-17
申请人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/506 , A61K31/4545 , A61K31/445 , A61P25/30
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
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公开(公告)号：US20120178781A1
公开(公告)日：2012-07-12
申请号：US13408309
申请日：2012-02-29
申请人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy CARROLL , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/4535 , A61K31/453 , A61P25/06 , A61P37/02 , A61P37/06 , A61P19/02 , A61P37/08 , A61P31/12 , A61P1/12 , A61P25/18 , A61P25/24 , A61P11/14 , A61P25/30 , A61P9/12 , A61P3/04 , A61P25/08 , C07D211/08
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对κ阿片样物质受体的功能性结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样物质受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的应用。
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公开(公告)号：US08173678B2
公开(公告)日：2012-05-08
申请号：US12911244
申请日：2010-10-25
申请人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
发明人： Frank Ivy Carroll , Hernan A. Navarro , Lawrence E. Brieaddy , Scott P. Runyon , James B. Thomas
IPC分类号： A61K31/451 , A61K31/453 , C07D227/06 , C07D471/18 , C07D211/18 , C07D401/12
CPC分类号： A61K31/445 , A61K31/4545 , A61K31/506 , A61K31/53 , C07D211/22 , C07D405/12 , C07D409/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
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公开(公告)号：US20090264462A1
公开(公告)日：2009-10-22
申请号：US12105814
申请日：2008-04-18
IPC分类号： A61K31/4725 , C07D403/12 , A61P43/00
CPC分类号： A61K31/451 , A61K31/4725 , A61K31/485 , C07D401/12
摘要： Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.
摘要翻译： 提供了卡帕阿片受体拮抗剂，其对卡帕阿片受体的功能结合测定产生显着的改善，以及这些拮抗剂在治疗通过κ阿片样受体如海洛因或可卡因成瘾的结合而改善的疾病状态中的用途。
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8.发明授权公开(公告)号：US08193213B2
公开(公告)日：2012-06-05
申请号：US12277708
申请日：2008-11-25
CPC分类号： A61K31/435 , A61K31/473 , Y02P20/582
摘要： Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
摘要翻译： 提供六氢茚基吡啶化合物，其用作杀精剂和/或杀真菌剂，含有它们的杀精和/或杀真菌组合物，以及使用该化合物和组合物杀死活动精子和/或真菌的方法。
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