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44 条记录 (耗时 0.035 秒)

    Transdermal delivery system for sufentanil
    11.
    发明授权
    Transdermal delivery system for sufentanil 有权
    舒芬太尼透皮给药系统

    公开(公告)号：US08252320B2

    公开(公告)日：2012-08-28

    申请号：US11888661

    申请日：2007-07-31

    申请人： Su Il Yum ,  Felix Theeuwes

    发明人： Su Il Yum ,  Felix Theeuwes

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/4535

    CPC分类号： A61K31/4535 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084

    摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

    摘要翻译： 提供了通过皮肤施用舒芬太尼的透皮递送系统。 当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。 该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂， 优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。 还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

    Transdermal delivery system for sufentanil
    12.
    发明授权
    Transdermal delivery system for sufentanil 有权

    公开(公告)号：US08252319B2

    公开(公告)日：2012-08-28

    申请号：US11888650

    申请日：2007-07-31

    申请人： Su Il Yum ,  Felix Theeuwes

    发明人： Su Il Yum ,  Felix Theeuwes

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/4535

    CPC分类号： A61K31/4535 ,  A61F2013/0296 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7084

    摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.

    Biodegradable implants with controlled bulk density
    13.
    发明申请
    Biodegradable implants with controlled bulk density 审中-公开
    具有可控堆积密度的可生物降解植入物

    公开(公告)号：US20090123518A1

    公开(公告)日：2009-05-14

    申请号：US12288537

    申请日：2008-10-20

    申请人： Su Il Yum ,  Sanjay Goskonda ,  Huey-Ching Su

    发明人： Su Il Yum ,  Sanjay Goskonda ,  Huey-Ching Su

    IPC分类号： A61F2/00 ,  A61K38/22

    CPC分类号： A61K9/0024 ,  A61K9/0004 ,  A61K38/09

    摘要： Disclosed solid water permeable implants that include a water permeable polymer and an osmotically active drug formulation that comprises a drug; wherein the solid water permeable implant has a ratio R of bulk density of the solid water permeable implant to osmotic pressure of the drug formulation wherein R is greater than about 0.244 grams/milliliter-atm. Also disclosed are methods of making and using such solid water permeable implants.

    摘要翻译： 公开的固体水可渗透植入物，其包括水可渗透聚合物和包含药物的渗透活性药物制剂; 其中固体水可渗透植入物具有固体水可渗透植入物的体积密度与药物制剂的渗透压的比R，其中R大于约0.244克/毫升。 还公开了制造和使用这种固体水可渗透植入物的方法。

    Transdermal drug delivery device
    14.
    再颁专利
    Transdermal drug delivery device 失效
    透皮给药装置

    公开(公告)号：USRE39588E1

    公开(公告)日：2007-04-24

    申请号：US07606462

    申请日：1990-10-31

    申请人： Eun Soo Lee ,  Su Il Yum

    发明人： Eun Soo Lee ,  Su Il Yum

    IPC分类号： A61F3/00

    CPC分类号： A61K9/7084

    摘要： A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

    摘要翻译： 描述了扩散药物递送装置，其可以提供粘合剂和系统组分的稳定性，消除药物的初始爆发并因此刺激，并且提供治疗效果的延迟开始以及以最佳速率递送治疗剂 。 适于储存的第一种形式的治疗剂和无水活化装置在无水环境中是惰性的。 水分激活系统，由此激活装置提供酸性或碱性溶液，并且将第一形式的治疗剂转化为适合于通过皮肤或粘膜吸收的第二种形式。

    Formulations for the transdermal administration of fenoldopam
    16.
    发明授权
    Formulations for the transdermal administration of fenoldopam 有权
    芬太尔康透皮给药制剂

    公开(公告)号：US06699497B1

    公开(公告)日：2004-03-02

    申请号：US09361026

    申请日：1999-07-23

    申请人： William W. van Osdol ,  Nieves M. Crisologo ,  Su Il Yum

    发明人： William W. van Osdol ,  Nieves M. Crisologo ,  Su Il Yum

    IPC分类号： A61F1302

    CPC分类号： A61K9/7084 ,  A61K9/0014 ,  A61K31/55 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18

    摘要： Composition of matter for application to a body surface or membrane to administer fenoldopam by permeation through the body surface or membrane, the composition comprising fenoldopam to be administered, at a therapeutically effective rate, in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of fenoldopam for the treatment of hypertension, congestive heart failure, and chronic and acute renal failure.

    摘要翻译： 用于施用于身体表面或膜的物质的组成，以通过穿过身体表面或膜的渗透来施用氟达泮，所述组合物包含要施用的非诺多泮，以治疗有效速率与渗透增强剂或混合物组合。 还公开了药物递送装置和用于透皮给药芬太尔康用于治疗高血压，充血性心力衰竭和慢性和急性肾衰竭的方法。

    Skin permeation enhancer compositions using acyl lactylates
    17.
    发明授权
    Skin permeation enhancer compositions using acyl lactylates 失效
    使用酰基乳酸盐的皮肤渗透促进剂组合物

    公开(公告)号：US5882676A

    公开(公告)日：1999-03-16

    申请号：US452468

    申请日：1995-05-26

    申请人： Eun Soo Lee ,  Su Il Yum

    发明人： Eun Soo Lee ,  Su Il Yum

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/14 ,  A61M37/00

    CPC分类号： A61K9/7084 ,  A61K47/14 ,  A61K9/0014 ,  Y10S514/947

    摘要： The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.

    摘要翻译： 本发明涉及药物与适量的酰基乳酸盐渗透促进剂的透皮给药。 本发明包括透皮药物递送装置，其包括适于与皮肤部位置于药物和渗透增强剂 - 传递关系中的基质。 基质含有足够量的酰基乳酸盐渗透促进剂和药物，以治疗有效的速率将药物连续地给予患者的全身循环。 本发明还涉及用于将药物与酰基乳酸盐渗透促进剂一起或与其它增强剂组合的透皮给药的组合物和方法。