-
11.发明授权
公开(公告)号：US5695757A
公开(公告)日：1997-12-09
申请号：US255557
申请日：1994-06-08
IPC分类号： A61K38/00 , C07K16/10 , A61K39/395 , C07K16/08 , C07K16/46
CPC分类号： C07K16/10 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： Pharmaceutical compositions that comprise a pharmaceutically acceptable carrier or diluent and a antibodies that each comprise at least a portion of the variable region from MAb 1112-1 are disclosed. Methods of treating individuals suspected of exposure to rabies are disclosed.
摘要翻译： 公开了包含药学上可接受的载体或稀释剂的药物组合物和各自包含来自MAb 1112-1的可变区的至少一部分的抗体。 公开了处理涉嫌狂犬病暴发的个体的方法。
-
公开(公告)号：US20080311147A1
公开(公告)日：2008-12-18
申请号：US11568006
申请日：2005-04-19
CPC分类号： C07K14/005 , A61K39/00 , A61K39/07 , A61K39/12 , A61K39/205 , A61K39/385 , A61K2039/6075 , C07K2319/00 , C07K2319/40 , C07K2319/55 , C07K2319/60 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143
摘要： Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA thereby forming the ribonucleoprotein (RNP) complex. Antigens presented in a rigid and repetitive organization are sufficient to activate B cells to proliferate. In addition to the repetitive organization, it has been shown that RV N protein induces potent T-helper responses resulting in long-lasting and strong humoral immune responses against RV. The possibility to directly manipulate the genome of RV allows us to examine whether the immunogenicity of foreign antigens can be enhanced via incorporation into the RNP structure. A recombinant RV expressing an RV N-green fluorescent protein (GFP) fusion protein. The chimeric N-GFP fusion protein was efficiently expressed and incorporated into RV RNP and virions. Moreover, the recombinant RNP induces a strong humoral immune response against GFP in mice. In contrast, mice inoculated with GFP alone or a combination of wild-type RV RNPs and GFP did not trigger any GFP-specific humoral responses using the same immunization schedule. These results indicate the usefulness of RV-based vectors as killed vaccines against other infectious diseases.
摘要翻译： 狂犬病病毒（RV）核蛋白（N）紧密地包裹基因组和反基因组RNA，从而形成核糖核蛋白（RNP）复合物。 呈现在刚性和重复组织中的抗原足以激活B细胞增殖。 除了重复组织之外，已经显示RVN蛋白诱导有效的T辅助反应，导致针对RV的持久和强烈的体液免疫应答。 直接操纵RV基因组的可能性使得我们能够检查外源抗原的免疫原性是否可以通过纳入RNP结构来增强。 表达RVN-绿色荧光蛋白（GFP）融合蛋白的重组RV。 嵌合的N-GFP融合蛋白被有效表达并并入RV RNP和病毒粒子中。 此外，重组RNP在小鼠中诱导针对GFP的强烈的体液免疫应答。 相比之下，用GFP单独接种的小鼠或野生型RV RNP和GFP的组合的小鼠不使用相同的免疫程序触发任何GFP特异性体液应答。 这些结果表明基于RV的载体作为针对其他感染性疾病的灭活疫苗的有用性。
-
公开(公告)号：US07223584B2
公开(公告)日：2007-05-29
申请号：US10268197
申请日：2002-10-10
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5254 , C12N2760/20134
摘要： Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of anti-rabies immunity in a subject.
摘要翻译： 包含过表达狂犬病病毒G蛋白的重组狂犬病病毒基因组的活狂犬病毒疫苗增加感染细胞中的凋亡活性，并增强受试者中抗狂犬病免疫的产生。
-
14.发明授权公开(公告)号：US07074413B2
公开(公告)日：2006-07-11
申请号：US09816531
申请日：2001-03-23
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/5254 , A61K2039/5256 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/20122 , C12N2760/20134 , C12N2760/20143 , C12N2760/20145 , C12N2760/20161 , C12N2810/6081
摘要： Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.
-
-
-
搜索结果
14 条记录 (耗时 0.042 秒)
