公开(公告)号：US4045343A

公开(公告)日：1977-08-30

申请号：US630122

申请日：1975-11-10

Applicant: Pierre Y. Achener ,  Detlef R. Boehme ,  Kenneth C. Judah ,  Miner N. Munk

Inventor： Pierre Y. Achener ,  Detlef R. Boehme ,  Kenneth C. Judah ,  Miner N. Munk

IPC: F04B7/00 ,  F04B49/20 ,  G01N30/32 ,  G01N30/36 ,  B01D15/08

CPC classification number: G01N30/36 ,  F04B49/20 ,  G01N2030/322 ,  G01N2030/326

Abstract: A high pressure liquid chromatography system including a reservoir for a liquid mobile phase, an LC column and detector, a high pressure reciprocating pump for enabling flow from said reservoir through the column, and a positively actuated inlet valve for controlling flow from the reservoir to the pump chamber. The pump is driven by motor means, such as a stepping motor, directly coupled thereto; and the inlet valve is actuated by the power train of the motor and pump, e.g., by an eccentric carried by the pump crank shaft. The pump piston is similarly driven by an eccentric, the pump and inlet valve eccentrics being angularly displaced in their respective positions at the crank shaft, as to delay opening of the inlet valve for a predetermined period following a pump stroke, so as to enable decompression of the liquid in the pump chamber.

Abstract translation: 包括用于液体流动相的储存器，LC柱和检测器的高压液相色谱系统，用于使得能够从所述储存器通过柱流动的高压往复泵以及用于控制从储存器到 泵室。 泵由马达装置驱动，例如直接与其连接的步进马达; 并且入口阀由马达和泵的动力传动系例如由泵曲轴承载的偏心元件驱动。 泵活塞类似地由偏心轮驱动，泵和入口阀偏心件在曲柄轴上的各自位置上成角度地移位，以便在泵冲程之后的预定时间段内延迟进口阀的打开，以便能够减压 的泵室中的液体。

公开(公告)号：US4006990A

公开(公告)日：1977-02-08

申请号：US669136

申请日：1976-03-22

Applicant: Miner N. Munk

Inventor： Miner N. Munk

IPC: G01N21/05 ,  G01N30/74 ,  G01N1/10

CPC classification number: G01N30/74 ,  G01N21/05

Abstract: Single and dual beam flow cells for liquid chromatography that provide good detectability and linear response with small sample volumes. A cylindrical window surrounds the sample flow path to permit focusing convergent light rays through the center of the flow path and along optical paths of equal length through the cell. Optical stops limit the light passing through the cell to convergent rays incident to the window surface. A wide acceptance angle for the rays results in high light transmission and averages variations in light output along the light source. A dual beam flow cell utilizes a common exit for the sample and reference liquids. The flow cells are economically constructed for direct coupling to a chromatographic column by using a standard compression fitting union and can be used in a single wavelength or discrete wavelength detector, or in a spectrophotometer.

Abstract translation: 用于液相色谱的单和双光束流动池，具有良好的可检测性和小样品体积的线性响应。 圆柱形窗口围绕样品流动路径，以允许将会聚的光线聚焦通过流动路径的中心并沿着相同长度的光路通过电池。 光学停止将通过电池的光限制在入射到窗表面的会聚光线。 光线的宽接受角导致高的透光率，并且平均沿着光源的光输出的变化。 双光束流动池利用样品和参比液体的共同出口。 经济地构建流动池，用于通过使用标准压缩配合接头直接耦合到色谱柱，并且可以在单个波长或离散波长检测器中或在分光光度计中使用。

公开(公告)号：US3975104A

公开(公告)日：1976-08-17

申请号：US490548

申请日：1974-07-22

Applicant: Miner N. Munk

Inventor： Miner N. Munk

IPC: B01L3/00 ,  G01N21/05 ,  G01N30/74 ,  G01N1/10

CPC classification number: G01N21/05 ,  G01N30/74

Abstract: Single and dual beam flow cells for liquid chromatography that provide good detectability and linear response with small sample volumes. A cylindrical window surrounds the sample flow path to permit focusing convergent light rays through the center of the flow path and along optical paths of equal length through the cell. Optical stops limit the light passing through the cell to convergent rays incident to the window surface. A wide acceptance angle for the rays results in high light transmission and averages variations in light output along the light source. A dual beam flow cell utilizes a common exit for the sample and reference liquids. The flow cells are economically constructed for direct coupling to a chromatographic column by using a standard compression fitting union and can be used in a single wavelength or discrete wavelength detector, or in a spectrophotometer.

Abstract translation: 用于液相色谱的单和双光束流动池，具有良好的可检测性和小样品体积的线性响应。 圆柱形窗口围绕样品流动路径，以允许将会聚的光线聚焦通过流动路径的中心并沿着相同长度的光路通过电池。 光学停止将通过电池的光限制在入射到窗表面的会聚光线。 光线的宽接受角导致高的透光率，并且平均沿着光源的光输出的变化。 双光束流动池利用样品和参比液体的共同出口。 经济地构建流动池，用于通过使用标准压缩配合接头直接耦合到色谱柱，并且可以在单个波长或离散波长检测器中或在分光光度计中使用。

公开(公告)号：US3930399A

公开(公告)日：1976-01-06

申请号：US490534

申请日：1974-07-22

Applicant: Miner N. Munk

Inventor： Miner N. Munk

IPC: G01N11/00

CPC classification number: G01N11/00

Abstract: Apparatus and method applicable to liquid chromatography for continuously detecting the viscosity of the effluent from an analysis column of a chromatograph system. The effluent is forced through a tubular path in a flow resistance element, which may contain a packing material to increase the amount of energy dissipated in the flow resistance element. The temperature of the effluent is sensed before and after passage through the path. A signal is generated which is a function of the difference between the value of temperature which is sensed before and after traversal of the effluent through the tubular path. From these measurements, the viscosity of the effluent may be computed as a function of the observed temperature change.

Abstract translation: 适用于液相色谱法的装置和方法，用于连续检测色谱系统分析柱的流出物的粘度。 流出物被迫通过流阻元件中的管路，其可以包含填充材料以增加在流阻元件中消散的能量的量。 在通过路径之前和之后感测流出物的温度。 产生信号，该信号是在穿过管状通道的流出物穿过之前和之后感测的温度值之间的差值的函数。 根据这些测量结果，流出物的粘度可以根据观察到的温度变化来计算。