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    Method of producing FR901228
    12.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US07396665B2

    公开(公告)日：2008-07-08

    申请号：US10362359

    申请日：2001-08-22

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： C12P21/06

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法

    Construction machine
    13.
    发明申请
    Construction machine 有权
    施工机械

    公开(公告)号：US20050149244A1

    公开(公告)日：2005-07-07

    申请号：US10924198

    申请日：2004-08-24

    申请人： Mitsunori Matsuda

    发明人： Mitsunori Matsuda

    IPC分类号： E02F3/00 ,  E02F9/16 ,  E02F9/26 ,  G06F19/00

    CPC分类号： E02F9/26

    摘要： To provide a construction machine capable of notifying an operator or the like of an energy saving state such that an engine thereof stops irrespective of the operator's will or the like. The construction machine wherein its engine is made in an energy saving state when an operator leaves from an operator's seat 13 and no work is performed includes display means 30 for displaying the energy saving state. The construction machine displays the energy saving state by the display means 30 by means of a display lamp 33 that is capable of being recognized from the outside of the machine, and displays the energy saving state by the display means 30 by means of a monitor screen 26 that is provided in an operator's cabin 11 as monitor display.

    摘要翻译： 提供能够通知操作者等节能状态的施工机械，使得其发动机停止，而与操作人员的意愿等无关。 当操作者离开操作者座椅13而不进行工作时，其发动机处于节能状态的工程机械包括用于显示节能状态的显示装置30。 施工机械借助于能够从机器的外部识别的显示灯33通过显示装置30显示节能状态，并且通过监视器屏幕显示由显示装置30的节能状态 26作为监视器显示器设置在操作室11中。

    Method of producing FR901228
    16.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US08445634B2

    公开(公告)日：2013-05-21

    申请号：US13473635

    申请日：2012-05-17

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K9/00

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

    METHOD OF PRODUCING FR901228
    17.
    发明申请
    METHOD OF PRODUCING FR901228 有权
    生产FR901228的方法

    公开(公告)号：US20120225829A1

    公开(公告)日：2012-09-06

    申请号：US13473633

    申请日：2012-05-17

    申请人： Satoshi UEDA ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi UEDA ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K38/07

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

    METHOD OF PRODUCING FR901228
    18.
    发明申请
    METHOD OF PRODUCING FR901228 审中-公开
    生产FR901228的方法

    公开(公告)号：US20090264343A1

    公开(公告)日：2009-10-22

    申请号：US12495239

    申请日：2009-06-30

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K38/16 ,  C07K1/00 ,  A61P35/00

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

    Method of producing FR901228
    20.
    发明授权
    Method of producing FR901228 有权
    生产FR901228的方法

    公开(公告)号：US07608280B2

    公开(公告)日：2009-10-27

    申请号：US12049746

    申请日：2008-03-17

    申请人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    发明人： Satoshi Ueda ,  Yoko Watamoto ,  Masaru Tsuboi ,  Munekazu Kanda ,  Tomoji Higaki ,  Mitsunori Matsuda

    IPC分类号： A61K9/00 ,  A61K38/12 ,  C07K7/64

    CPC分类号： C12P21/02 ,  C07K5/101

    摘要： Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion. Also provided are crystalline forms of FR901228, e.g., type A and type B crystalline forms of FR901228.

    摘要翻译： 公开了具有结构（I）的脱肽和同系物，其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。 这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及​​用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者 移植后的移植物/组织存活。 还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。 还提供了FR901228的结晶形式，例如FR901228的A型和B型结晶形式。