摘要:
A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome.
摘要翻译:由下式(I)表示的磷脂衍生物,其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数, 符号“b”表示0或1,条件是当a为0时,b为0; X表示氢原子,碱金属原子,铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基,其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m,n和q满足以下条件:5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /(m + n + q)和q /(m + n + q)<= 0.8,这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳,从而增加稳定性 的脂质体。
摘要:
A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3≦m≦200, 9≦m×(k1+k2+k3)≦1000, 1≦k1≦2, 0≦k2≦9 and 0≦k3≦9, and 3≦k1+k2+k3≦10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
摘要:
A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile solvent and, then, dispersing the mixture in an aqueous medium. The pharmaceutically acceptable liposome preparation as a drug delivery system can thus be produced with efficiency on an industrial scale.
摘要:
There are provided a communications method, a communications system, a relay apparatus, and a computer program in which the communication remains stable between a terminal unit such as a mobile IP telephone and the relay apparatus used as an access point in the streaming communication service such as IP telephone in a wireless LAN environment when the condition of communication is unfavorable. The relay apparatus (1) is arranged to, when a desired amount of data for the streaming service is transmitted to each of the terminal units (2) over a communication bandwidth assigned to the terminal unit (2) at a communication speed predetermined for the terminal unit (2), modify the communication speed to the lowest rate.
摘要:
A data processing apparatus edits an actual data portion excluding a header from data transmitted by streaming transmission from a first information processing apparatus after start of streaming transmission. The data processing apparatus transmits edited actual data portion and header to a second information processing apparatus by streaming transmission. The second information processing apparatus reproduces the voice data or the animation data transmitted by streaming transmission. The actual data portion is edited so that the voice data or the animation data to be transmitted may be reproducible in the second information processing apparatus, and so that a program may become unexecutable even if it would be transmitted to the second information processing apparatus. Even if the voice data or the animation data transmitted from the first information processing apparatus by streaming transmission would be deteriorated, an executable virus program does not transmitted to the second information processing apparatus, thereby that makes it possible to realize the streaming transmission method which can realize simple and high security.
摘要:
A relay apparatus for relaying communication between a plurality of wireless terminals and a wired network includes a priority data recording part for recording communication identification data and required bandwidth data, a priority control part for relaying, by priority, the communication recorded in the priority data recording part, a request receiving part for receiving communication identification data and multimedia type data, a selecting part for selecting a multimedia type to be relayed by priority, an updating part for additionally recording data that represents a bandwidth required for relaying a stream of the selected multimedia type and the communication identification data, and a responding part for transmitting a response. The selecting part selects the multimedia type so that a sum of bandwidths represented by the required bandwidth data does not exceed a predetermined upper limit value. With the above configuration, the relay apparatus can perform bandwidth control of communication to be relayed, considering the multimedia type included in the communication by a wireless terminal.
摘要:
A medicament used for prophylactic and/or therapeutic treatment of xerostomia, which is in the form for oral mucosal administration comprising a spirooxathiolane quinuclidine derivative represented by the following general formula (I) or an acid addition salt thereof:[Formula 1] (wherein R1 and R2 may be the same or different, and independently represent a hydrogen atom, an alkyl group, a cyclopentyl group, a cyclohexyl group, a monoaryl- or diaryl-substituted methylol group, or an aryl-substituted alkyl group) as an active ingredient.
摘要:
A communication relay device adds information to communication data without depending on a communication application of a communication terminal. The relay device (1) includes a relay control portion (13), a control information database (14), an adder portion (15) and a database for addition (16). The relay control portion (13) controls the adder portion (15) in accordance with information accumulated in the control information DB 14. The adder portion (15) adds the additional data accumulated in the database for addition (16) to decoded first contents in accordance with a control instruction by the relay control portion (13).
摘要:
A developing blade (1) comprises a support member (2) having a coefficient of elasticity in the range of 0.5×104 to 4.0×104 kg/mm2 and a moment of inertia of area (Iz) in the range of 6.5E-04 to 1.2E-02, and a blade member (4) located on one surface of the support member (2) along one side edge (2A). The blade member (4) is made of a rubber material having a 25% modulus of no greater than 0.85 MPa, and has a moment of inertia of area (Iz) in the range of 8E-02 to 1.2E+01, and the blade member (4) has a warping of no greater than 10 mm in the longitudinal direction.
摘要翻译:显影叶片(1)包括具有在0.5×10 4至4.0×10 4 kg / mm 2范围内的弹性系数的弹性系数的支撑构件(2),并且面积(Iz)的惯性矩在6.5E-04的范围内 至1.2E-02,以及沿着一个侧边缘(2A)位于支撑构件(2)的一个表面上的刀片构件(4)。 叶片构件(4)由25%模量不大于0.85MPa的橡胶材料制成,并且具有在8E-02至1.2E + 01范围内的面积(Iz)的惯性矩,并且 叶片构件(4)在纵向上具有不大于10mm的翘曲。
摘要:
In a network including a relay apparatus, a relay apparatus management part, a communication management server for controlling communication between communication terminals including a mobile communication terminal, and a messaging server, a communication support system that supports an establishment of connection between communication terminals includes a communication information acquiring part for, in a case where communication cannot be established between a mobile communication terminal and a partner-side terminal due to the congestion of communication, receiving terminal data thereof, a relay apparatus specifying part for specifying an alternative relay apparatus, and a message control part for causing a messaging server to perform processing of transmitting an inquiry message for inquiring about a possibility of movement to a coverage area of the alternative relay apparatus and processing of transmitting a content of a response message. The communication support system enables a rapid transition to a state in which communication between the mobile communication terminal and the partner-side terminal can be established, by allowing information to be exchanged between both the terminals, even in a case where the communication between the terminal and the relay apparatus is congested.