公开(公告)号：US20150183794A1

公开(公告)日：2015-07-02

申请号：US14643275

申请日：2015-03-10

Applicant: Novartis AG

Inventor： Dominik Feuerbach ,  Konstanze Hurth ,  Timothy John Ritchie ,  Rochdi Bouhelal

IPC: C07D487/08 ,  C07D453/02

CPC classification number: A61K31/439 ,  A61K9/20 ,  A61K31/444 ,  C07D453/02 ,  C07D487/08

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。

公开(公告)号：US20200048236A1

公开(公告)日：2020-02-13

申请号：US16378887

申请日：2019-04-09

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D471/04 ,  A61K31/5377 ,  C07D487/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US20190083474A1

公开(公告)日：2019-03-21

申请号：US16191693

申请日：2018-11-15

Applicant: Novartis AG

Inventor： Dominik Feuerbach ,  Konstanze Hurth ,  Timothy John Ritchie ,  Rochdi Bouhelal

IPC: A61K31/439 ,  C07D453/02 ,  A61K31/444 ,  A61K9/20 ,  C07D487/08

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

公开(公告)号：US09849117B2

公开(公告)日：2017-12-26

申请号：US15398427

申请日：2017-01-04

Applicant: Novartis AG

Inventor： Dominik Feuerbach ,  Konstanze Hurth ,  Timothy John Ritchie ,  Rochdi Bouhelal

IPC: A61K31/439 ,  A61K31/44 ,  A61K9/20 ,  A61K31/444

CPC classification number: A61K31/439 ,  A61K9/20 ,  A61K31/444 ,  C07D453/02 ,  C07D487/08

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

公开(公告)号：US09657010B2

公开(公告)日：2017-05-23

申请号：US14068004

申请日：2013-10-31

Applicant: NOVARTIS AG

Inventor： Dominik Feuerbach ,  Mathias Frederiksen ,  Konstanze Hurth ,  Bernard Lucien Roy

IPC: C07D453/02 ,  C07D487/08

CPC classification number: C07D453/02 ,  C07D487/08

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I) wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals in the prevention and treatment of psychotic and neurodegenerative disorders. The claimed compounds act as nicotinic acetylcholine receptors (NACHR) ligands.

公开(公告)号：US09567343B2

公开(公告)日：2017-02-14

申请号：US14643275

申请日：2015-03-10

Applicant: Novartis AG

Inventor： Dominik Feuerbach ,  Konstanze Hurth ,  Timothy John Ritchie ,  Rochdi Bouhelal

IPC: C07D453/02 ,  C07D487/08 ,  A61K31/439 ,  A61K31/4439

CPC classification number: A61K31/439 ,  A61K9/20 ,  A61K31/444 ,  C07D453/02 ,  C07D487/08

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。