公开(公告)号：US10035794B2

公开(公告)日：2018-07-31

申请号：US15385147

申请日：2016-12-20

Applicant: NOVARTIS AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/5377 ,  C07B59/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US11541056B2

公开(公告)日：2023-01-03

申请号：US16981208

申请日：2019-03-25

Applicant: NOVARTIS AG

Inventor： Luca Arista ,  Christina Hebach ,  Gregory John Hollingworth ,  Philipp Holzer ,  Patricia Imbach-Weese ,  Rainer Machauer ,  Niko Schmiedeberg ,  Anna Vulpetti ,  Thomas Zoller

IPC: C07D519/00 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

公开(公告)号：US20200048236A1

公开(公告)日：2020-02-13

申请号：US16378887

申请日：2019-04-09

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D471/04 ,  A61K31/5377 ,  C07D487/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US10112907B2

公开(公告)日：2018-10-30

申请号：US15711984

申请日：2017-09-21

Applicant: NOVARTIS AG

Inventor： Badry Bursulaya ,  Andreas Fisch ,  James Paul Lajiness ,  Rainer Machauer ,  Swapnil Malekar ,  Hank Michael James Petrassi ,  Farshad Ramazani ,  Anne-Catherine Remond ,  Thomas Ullrich ,  Peggy Usselmann ,  Eric Vangrevelinghe

IPC: A61K31/416 ,  C07D231/56 ,  A61K9/00 ,  A61K9/16 ,  A61K31/454 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.