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公开(公告)号：US5525616A
公开(公告)日：1996-06-11
申请号：US439842
申请日：1995-05-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
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公开(公告)号：US5472969A
公开(公告)日：1995-12-05
申请号：US321718
申请日：1994-10-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
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公开(公告)号：US06660749B2
公开(公告)日：2003-12-09
申请号：US10244628
申请日：2002-09-17
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
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公开(公告)号：US06465488B1
公开(公告)日：2002-10-15
申请号：US09553951
申请日：2000-04-21
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
摘要翻译： 本文公开了使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。 本发明涉及利用抑制受影响细胞中葡糖基转移酶活性的化合物治疗脂质贮积病。 特别涉及1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇及其衍生物的用途。
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公开(公告)号：US06291657B1
公开(公告)日：2001-09-18
申请号：US08102654
申请日：1993-08-05
IPC分类号： C07H1500
CPC分类号： A61K31/131 , C07D211/46 , Y02A50/471
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译： 提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。 这些新型化合物可用于选择性抑制糖脂合成。
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公开(公告)号：US5399567A
公开(公告)日：1995-03-21
申请号：US61645
申请日：1993-05-13
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
摘要翻译： 本发明公开了一种通过施用有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或其衍生物来治疗人的霍乱感染的方法。
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公开(公告)号：US5801185A
公开(公告)日：1998-09-01
申请号：US782322
申请日：1997-01-13
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for the treatment of Tay-Sachs disease comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了用于治疗泰萨氏病的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中所述烷基含有 2-8个碳原子。
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公开(公告)号：US5656641A
公开(公告)日：1997-08-12
申请号：US393640
申请日：1995-02-24
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
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公开(公告)号：US5580884A
公开(公告)日：1996-12-03
申请号：US396989
申请日：1995-03-01
IPC分类号： A61K31/131 , A61K31/445 , A61P3/00 , A61P31/04 , A61P43/00 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译： 提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。 这些新型化合物可用于选择性抑制糖脂合成。
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公开(公告)号：US08450345B2
公开(公告)日：2013-05-28
申请号：US12656992
申请日：2010-02-22
IPC分类号： A61K31/445 , A61P31/20
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
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