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公开(公告)号：US09089515B2
公开(公告)日：2015-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , A61P31/12 , A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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公开(公告)号：US20110184019A1
公开(公告)日：2011-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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公开(公告)号：US06660749B2
公开(公告)日：2003-12-09
申请号：US10244628
申请日：2002-09-17
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
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公开(公告)号：US06465488B1
公开(公告)日：2002-10-15
申请号：US09553951
申请日：2000-04-21
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445
摘要： Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with compounds that inhibit glucosyltransferase activity in the affected cells. It relates particularly to the use of 1,5-dideoxy-1,5-imino-D-glucitol and derivatives thereof.
摘要翻译： 本文公开了使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。 本发明涉及利用抑制受影响细胞中葡糖基转移酶活性的化合物治疗脂质贮积病。 特别涉及1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇及其衍生物的用途。
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公开(公告)号：US06291657B1
公开(公告)日：2001-09-18
申请号：US08102654
申请日：1993-08-05
IPC分类号： C07H1500
CPC分类号： A61K31/131 , C07D211/46 , Y02A50/471
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译： 提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。 这些新型化合物可用于选择性抑制糖脂合成。
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公开(公告)号：US5399567A
公开(公告)日：1995-03-21
申请号：US61645
申请日：1993-05-13
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
摘要翻译： 本发明公开了一种通过施用有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或其衍生物来治疗人的霍乱感染的方法。
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7.发明授权
公开(公告)号：US5786369A
公开(公告)日：1998-07-28
申请号：US650558
申请日：1996-05-20
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了通过使细菌细胞抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物来抑制细菌的糖脂受体表面表达的方法，其中所述烷基含 2-8个碳原子。
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公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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公开(公告)号：US6069235A
公开(公告)日：2000-05-30
申请号：US202055
申请日：1994-02-23
申请人： Simon J. Davis , Terence D. Butters , Gunilla B. Karlsson , Frances M. Platt , Martin L. Bryant , Raymond A. Dwek
发明人： Simon J. Davis , Terence D. Butters , Gunilla B. Karlsson , Frances M. Platt , Martin L. Bryant , Raymond A. Dwek
IPC分类号： C07K14/705 , C07K14/725 , C12N1/38 , C12N15/12 , C12P21/00 , C07K1/113
CPC分类号： C12P21/005 , C07K14/70507 , C12N1/38 , C07K2319/00 , G01N2333/924
摘要： A method is disclosed for modifying the carbohydrate moiety on glycoproteins to facilitate the structural and functional analysis of said glycoproteins such as by NMR spectroscopic analysis and crystallography which comprises treating glycoprotein-secreting mammalian cells having low endomannosidase activity under cell culture maintenance conditions with a glucosidase I inhibitor, and after secretion and purification, subsequent treatment of the active glycoprotein with endoglycosidase H to thereby provide a glycoprotein with a single GlcNAc residue at each glycosylation sequon. The preferred mammalian cells are CHO cells and the preferred glucosidase I inhibitor is N-butyl deoxynojirimycin.
摘要翻译： 公开了一种用于修饰糖蛋白上的碳水化合物部分以促进所述糖蛋白的结构和功能分析的方法，例如通过NMR光谱分析和结晶学，其包括在细胞培养维持条件下用葡糖苷酶I处理具有低内切糖苷酶活性的糖蛋白分泌哺乳动物细胞 并且在分泌和纯化后，随后用糖糖苷内切酶H处理活性糖蛋白，从而在每个糖基化序列中提供具有单个GlcNAc残基的糖蛋白。 优选的哺乳动物细胞是CHO细胞，优选的葡糖苷酶I抑制剂是N-丁基脱氧野尻霉素。
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公开(公告)号：US5472969A
公开(公告)日：1995-12-05
申请号：US321718
申请日：1994-10-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
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