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1.发明授权
公开(公告)号：US5786369A
公开(公告)日：1998-07-28
申请号：US650558
申请日：1996-05-20
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了通过使细菌细胞抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物来抑制细菌的糖脂受体表面表达的方法，其中所述烷基含 2-8个碳原子。
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公开(公告)号：US5472969A
公开(公告)日：1995-12-05
申请号：US321718
申请日：1994-10-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
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公开(公告)号：US06291657B1
公开(公告)日：2001-09-18
申请号：US08102654
申请日：1993-08-05
IPC分类号： C07H1500
CPC分类号： A61K31/131 , C07D211/46 , Y02A50/471
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译： 提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。 这些新型化合物可用于选择性抑制糖脂合成。
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公开(公告)号：US5399567A
公开(公告)日：1995-03-21
申请号：US61645
申请日：1993-05-13
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
摘要翻译： 本发明公开了一种通过施用有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或其衍生物来治疗人的霍乱感染的方法。
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公开(公告)号：US5798366A
公开(公告)日：1998-08-25
申请号：US782321
申请日：1997-01-13
IPC分类号： C07H15/12 , A61K31/445 , A61K31/70 , A61K31/7028 , A61P3/00 , A61P25/00
CPC分类号： A61K31/7004 , A61K31/445 , A61K31/70 , A61K31/7012
摘要： A method is disclosed for the in vivo treatment of patients having a lysosomal storage disease with a significant central nervous system (CNS) involvement. Said method comprises administration to said patient a small but storage-inhibitory effective amount of an N-alkyl derivative of a 1,5-iminosugar in which said alkyl group contains from about 2 to about 8 carbon atoms and said 1,5-iminosugar is 1,5-dideoxy-1,5-imino-D-glucitol, or 1,5-dideoxy-1,5-imino-D-galactitol, or an O-acylated pro-drug of said 1,5-iminosugar. In an illustrative example, CNS storage of GM2 ganglioside is inhibited in Tay-Sachs mice by administration of 1,5-(butylimino)-1,5-dideoxy-D-glucitol.
摘要翻译： 公开了一种用于体内治疗具有显着的中枢神经系统（CNS）参与的溶酶体贮积病的患者的方法。 所述方法包括向所述患者施用小的但储存抑制的有效量的1,5-亚氨基二糖的N-烷基衍生物，其中所述烷基含有约2至约8个碳原子，所述1,5-亚氨基二糖是 1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇或1,5-二脱氧-1,5-亚氨基-D-半乳糖醇，或所述1,5-亚氨基二糖的O-酰化前体药。 在说明性实例中，通过施用1,5-（丁基亚氨基）-1,5-二脱氧-D-葡萄糖醇，在Tay-Sachs小鼠中GM2神经节苷脂的CNS储存被抑制。
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公开(公告)号：US5786368A
公开(公告)日：1998-07-28
申请号：US588027
申请日：1996-01-17
IPC分类号： A61K31/131 , A61K31/445 , A61P3/00 , A61P31/04 , A61P43/00 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
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公开(公告)号：US5525616A
公开(公告)日：1996-06-11
申请号：US439842
申请日：1995-05-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
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公开(公告)号：US5801185A
公开(公告)日：1998-09-01
申请号：US782322
申请日：1997-01-13
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for the treatment of Tay-Sachs disease comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了用于治疗泰萨氏病的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中所述烷基含有 2-8个碳原子。
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公开(公告)号：US5656641A
公开(公告)日：1997-08-12
申请号：US393640
申请日：1995-02-24
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
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公开(公告)号：US5580884A
公开(公告)日：1996-12-03
申请号：US396989
申请日：1995-03-01
IPC分类号： A61K31/131 , A61K31/445 , A61P3/00 , A61P31/04 , A61P43/00 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
摘要翻译： 提供脱氧半乳糖吉非霉素的新型N-烷基衍生物，其中所述烷基含有3-6个碳原子。 这些新型化合物可用于选择性抑制糖脂合成。
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