公开(公告)号：US12171839B2

公开(公告)日：2024-12-24

申请号：US17833077

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Anthony Edward Boitano ,  Matthew Burger ,  Susan E. Cellitti ,  Michael P. Cooke ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Yunho Jin ,  Si Tuen Lee-Hoeflich ,  HongNgoc Thi Pham ,  Siew Ho Schleyer ,  Kathrin Tissot ,  Tetsuo Uno ,  Ben Wen

IPC: C07K16/00 ,  A61K38/07 ,  A61K38/12 ,  A61K47/68 ,  C07K16/28 ,  C07K16/46

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US11596695B2

公开(公告)日：2023-03-07

申请号：US16701576

申请日：2019-12-03

Applicant: Novartis AG

Inventor： Bernhard Hubert Geierstanger ,  Weijia Ou ,  Tetsuo Uno

IPC: A61K47/68 ,  C07K16/32 ,  C07K16/28

Abstract: The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.

公开(公告)号：US10786578B2

公开(公告)日：2020-09-29

申请号：US15329818

申请日：2015-07-27

Applicant: Novartis AG

Inventor： Tinya Abrams ,  Steven Bruce Cohen ,  Dylan Daniel ,  Catrin Finner ,  Bernhard Hubert Geierstanger ,  Thomas Huber ,  William Mallet ,  Matthew John Meyer ,  Weijia Ou ,  Siew Ho Schleyer ,  Kathrin Ulrike Tissot-Daguette

IPC: A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  A61K51/10 ,  A61K49/00 ,  A61P35/02 ,  A61K39/395

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

公开(公告)号：US10392421B2

公开(公告)日：2019-08-27

申请号：US15961531

申请日：2018-04-24

Applicant: NOVARTIS AG

Inventor： Bernhard Hubert Geierstanger ,  Jan Grunewald ,  Yunho Jin ,  Weijia Ou ,  Tetsuo Uno ,  Yongqin Wan ,  Xing Wang

IPC: C07K5/02 ,  A61K47/68 ,  C07K7/02 ,  C07K16/32

Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.