公开(公告)号：US11667613B2

公开(公告)日：2023-06-06

申请号：US17030540

申请日：2020-09-24

Applicant: Novartis AG ,  Gilead Sciences, Inc.

Inventor： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/4162 ,  A61K31/437 ,  A61P31/22 ,  C07D243/10

CPC classification number: C07D243/10

Abstract: The invention provides compounds of Formula (I)




as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US11098051B2

公开(公告)日：2021-08-24

申请号：US16328616

申请日：2017-08-25

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/16 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US10858366B2

公开(公告)日：2020-12-08

申请号：US16083089

申请日：2017-03-07

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.

公开(公告)号：US20200079772A1

公开(公告)日：2020-03-12

申请号：US16569107

申请日：2019-09-12

Applicant: Novartis AG

Inventor： Christopher Becker ,  Xiaolin Li ,  Peichao Lu ,  Naomi Samadara Rajapaksa ,  David Charles Tully ,  Xiaojing Michael Wang ,  Qian Zhao

IPC: C07D471/04 ,  A61P31/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US20250034156A1

公开(公告)日：2025-01-30

申请号：US18764058

申请日：2024-07-03

Applicant: Novartis AG

Inventor： Maxime Dauphinais ,  Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  Lifeng Wan ,  Xiaojing Michael Wang ,  Aregahegn Yifru ,  Qian Zhao

IPC: C07D487/14 ,  C07D498/14

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US10112931B2

公开(公告)日：2018-10-30

申请号：US15499824

申请日：2017-04-27

Applicant: NOVARTIS AG

Inventor： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Clifford Sutton ,  Yaping Wang ,  Qian Zhao

IPC: C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06

Abstract: The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

公开(公告)号：US09688672B2

公开(公告)日：2017-06-27

申请号：US15209731

申请日：2016-07-13

Applicant: NOVARTIS AG

Inventor： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Clifford Sutton ,  Yaping Wang ,  Qian Zhao

IPC: C07D413/14 ,  A61K31/506 ,  C07D413/04 ,  C07D417/14 ,  A61K31/5377

CPC classification number: C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

Abstract: The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.