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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2023/04/18/US11629149B2/abs.jpg.150x150.jpg)
公开(公告)号：US11629149B2
公开(公告)日：2023-04-18
申请号：US16975784
申请日：2019-02-26
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号：US10660888B2
公开(公告)日：2020-05-26
申请号：US16210968
申请日：2018-12-05
Applicant: Novartis AG
Inventor： Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC: A61K31/497 , C07D213/73 , C07D401/06 , C07D401/12 , C07D403/06 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04 , A61K31/44 , A61K31/4433 , A61K31/5355
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号：US10160764B2
公开(公告)日：2018-12-25
申请号：US15686652
申请日：2017-08-25
Applicant: Novartis AG
Inventor： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D471/14 , C07D498/14 , A61K31/5025
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2024/08/27/US12071441B2/abs.jpg.150x150.jpg)
公开(公告)号：US12071441B2
公开(公告)日：2024-08-27
申请号：US18114336
申请日：2023-02-27
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
CPC classification number: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza](/abs-image/US/2023/10/12/US20230322793A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230322793A1
公开(公告)日：2023-10-12
申请号：US18114336
申请日：2023-02-27
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
CPC classification number: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
Patent Agency Ranking
公开(公告)号：US20160263113A1
公开(公告)日：2016-09-15
申请号：US15070905
申请日：2016-03-15
Applicant: Novartis AG
Inventor： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC: A61K31/506 , A61K31/4184
CPC classification number: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
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公开(公告)号：US11912715B2
公开(公告)日：2024-02-27
申请号：US17374237
申请日：2021-07-13
Applicant: Novartis AG
Inventor： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D471/14 , C07D498/14 , A61P31/16 , A61K31/551 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/5025
CPC classification number: C07D487/14 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551 , A61P31/16 , C07D471/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
公开(公告)号：US11098051B2
公开(公告)日：2021-08-24
申请号：US16328616
申请日：2017-08-25
Applicant: Novartis AG
Inventor： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin Robert Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D471/14 , C07D498/14 , A61P31/16 , A61K31/16 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号：US20160120866A1
公开(公告)日：2016-05-05
申请号：US14994827
申请日：2016-01-13
Applicant: Novartis AG
Inventor： Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC: A61K31/506 , A61K31/4184 , A61K9/00
CPC classification number: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza](/abs-image/US/2025/01/30/US20250034156A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250034156A1
公开(公告)日：2025-01-30
申请号：US18764058
申请日：2024-07-03
Applicant: Novartis AG
Inventor： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC: C07D487/14 , C07D498/14
Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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