公开(公告)号：US20170115474A1

公开(公告)日：2017-04-27

申请号：US15402457

申请日：2017-01-10

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya FUKUYAMA

IPC: G02B21/00 ,  G01J1/44 ,  G02B21/02

CPC classification number: G02B21/006 ,  G01J1/44 ,  G01N21/6458 ,  G02B3/06 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/02 ,  G02B23/26

Abstract: In order to obtain a clear final image by preventing scratches, foreign objects, defects, or the like of an optical device from becoming superimposed on an intermediate image even when the intermediate image is formed at a position that overlaps with the optical device, this imaging optical system has a plurality of imaging lenses that form a final image and at least one intermediate image; a first phase-modulating element disposed closer to an object than any one of the intermediate images, for imparting a spatial disturbance to a wavefront of light coming from the object; and a second phase-modulating element integrated with at least one optical element of the imaging lens, wherein the second phase-modulating element cancels the spatial disturbance imparted to the wavefront of the light coming from the object by the first phase-modulating element.

公开(公告)号：US20160025970A1

公开(公告)日：2016-01-28

申请号：US14873592

申请日：2015-10-02

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya FUKUYAMA

IPC: G02B27/00 ,  G02B21/04 ,  G02B21/36 ,  G02B21/00

CPC classification number: G02B27/0068 ,  G02B3/08 ,  G02B5/18 ,  G02B5/1861 ,  G02B5/1866 ,  G02B5/1871 ,  G02B5/1876 ,  G02B13/08 ,  G02B13/22 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/04 ,  G02B21/361 ,  G02B26/06 ,  G02B27/0037 ,  G02F1/01 ,  G02F2203/50

Abstract: An image-forming optical system includes a plurality of image-forming lenses that form a final image and at least one intermediate image; a first phase modulator that is disposed closer to an object side than any one of the intermediate images formed by the image-forming lenses and that applies a spatial disturbance to a wavefront of light coming from the object; and a second phase modulator that is disposed at a position that sandwiches at least one of the intermediate images with the first phase modulator and that cancels out the spatial disturbance applied to the wavefront of the light coming from the object by the first phase modulator.

Abstract translation: 图像形成光学系统包括形成最终图像和至少一个中间图像的多个图像形成透镜; 第一相位调制器被设置为比由成像透镜形成的任何一个中间图像更靠近物体侧，并且对来自物体的光的波前施加空间干扰; 以及第二相位调制器，其设置在将所述中间图像中的至少一个与所述第一相位调制器夹持的位置，并且消除由所述第一相位调制器施加到来自所述物体的光的波前的空间干扰。

公开(公告)号：US20150355094A1

公开(公告)日：2015-12-10

申请号：US14829983

申请日：2015-08-19

Applicant: OLYMPUS CORPORATION

Inventor： Hiroya FUKUYAMA

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N2201/10 ,  G01N2201/121 ,  G02B21/06 ,  G02B21/365

Abstract: A high-resolution fluorescence image in which an afterimage is suppressed is obtained, even when a fluorescence detection interval is shortened. Provided is a scanning observation apparatus including a scanning unit that spatially scans pulsed excitation light emitted from a light source at prescribed time intervals on a specimen; a fluorescence detecting unit that detects fluorescence generated by exciting a fluorescent substance inside the specimen with the excitation light scanned by the scanning unit, in synchronization with the emission of the excitation light; and a fluorescence correcting unit that subtracts, from a fluorescence intensity detected by the fluorescence detecting unit, an afterimage fluorescence component calculated on the basis of time-sequential fluorescence detected by the fluorescence detecting unit prior thereto, at each scanning position, to correct the fluorescence intensity at the scanning position.

Abstract translation: 即使在荧光检测间隔缩短的情况下也能够得到抑制残像的高分辨率的荧光图像。 本发明提供一种扫描观察装置，其具备：扫描单元，其以规定的时间间隔在样本上空间扫描从光源发出的脉冲激发光; 荧光检测单元，其与通过所述激发光的发射同步地检测利用所述扫描单元扫描的激发光来激发所述样本内的荧光物质而产生的荧光; 以及荧光校正单元，从荧光检测单元检测出的荧光强度，在每个扫描位置根据荧光检测单元检测到的时间序列荧光计算的余像荧光成分，从而校正荧光 在扫描位置的强度。