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公开(公告)号：US09207179B2
公开(公告)日：2015-12-08
申请号：US14738010
申请日：2015-06-12
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
IPC: G01N21/64
CPC classification number: G01N21/6456 , A61B1/00009 , A61B1/043 , A61B1/0638 , G01N2021/6471 , G01N2201/061 , G02B21/16 , G02B23/2423 , G02B23/26 , G06T5/50 , G06T2207/10064 , G06T2207/10068 , G06T2207/20221
Abstract: A fluorescence observation apparatus, including: a light source configured to irradiate a subject with reference light and excitation light; and one or more processors including hardware, wherein the one or more processers are configured to implement: a fluorescence-image generating portion configured to generate a fluorescence image; a reference-image generating portion configured to generate a color reference image; an extraction portion configured to extract a fluorescence region from the fluorescence image; a motion-effect generating portion configured to generate a frame image bringing about an effect that is visually time-varying with a variation quantity depending on a gradation value of the fluorescence region, in a region corresponding to the fluorescence region; and a synthesis portion configured to add the frame image to any of a plurality of color-component images constituting the reference image to synthesize a synthetic image.
Abstract translation: 一种荧光观察装置，包括：被配置为用参考光和激发光照射对象的光源; 以及包括硬件的一个或多个处理器，其中所述一个或多个处理器被配置为实现：被配置为生成荧光图像的荧光图像生成部分; 参考图像生成部，被配置为生成颜色参考图像; 提取部，被配置为从所述荧光图像提取荧光区域; 运动效果生成部，被配置为在对应于所述荧光区域的区域中生成引起视觉上随着所述荧光区域的灰度值的变化量而视觉上随时间变化的效果的帧图像; 以及合成部，被配置为将帧图像添加到构成参考图像的多个颜色分量图像中的任何一个，以合成合成图像。
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公开(公告)号：US09055862B2
公开(公告)日：2015-06-16
申请号：US13727164
申请日：2012-12-26
Applicant: Olympus Corporation
Inventor： Toshiaki Watanabe , Yasushige Ishihara
CPC classification number: A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646 , G02B23/2461 , G02B23/2484
Abstract: Provided is an image processing device including an illuminating portion that irradiates a subject with illumination light and excitation light; a fluorescence image-acquisition portion that acquires a fluorescence image by capturing fluorescence generated at the subject; a return-light image-acquisition portion that acquires a return-light image by capturing return light returning from the subject; a color-image generating portion that generates a plurality of color images by adding different types of color information that constitute a color space to the acquired fluorescence image and return-light image; and an image combining portion that combines the plurality of color images that have been generated, wherein at least one of the fluorescence image and the return-light image is subjected to, by the color-image generating portion), correction processing in which exponents for distance characteristics, which are approximated to exponential functions, for the fluorescence image and the return-light image are matched with each other.
Abstract translation: 提供一种图像处理装置，包括：照明部，其对照明光和激发光进行照射; 荧光图像获取部，其通过捕获在所述对象产生的荧光获取荧光图像; 返回光图像获取部分，通过捕获从被摄体返回的返回光来获取返回光图像; 彩色图像生成部，其通过向所获取的荧光图像和返回光图像添加构成颜色空间的不同类型的颜色信息来生成多个彩色图像; 以及组合所生成的多个彩色图像的图像组合部分，其中通过彩色图像生成部分对荧光图像和返回光图像中的至少一个进行处理），校正处理，其中指数 对于荧光图像和返回光图像，近似于指数函数的距离特性彼此匹配。
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公开(公告)号：US09949645B2
公开(公告)日：2018-04-24
申请号：US14033687
申请日：2013-09-23
Applicant: OLYMPUS CORPORATION
Inventor： Hiromi Shida , Yasushige Ishihara
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/0005 , A61B1/043 , G02B23/2469 , G02B2207/113
Abstract: A fluorescence imaging apparatus including: a processor comprising hardware, configured to: specify a processing condition to be used to process a fluorescence image in accordance with treatment-details information indicating specifics of a treatment to be performed on a biological tissue; in a case where a first processing condition is specified, identify a first fluorescence region in the fluorescence image having a predetermined first fluorescence intensity based on the first processing condition; in a case where a second processing condition is specified, identify a second fluorescence region in the fluorescence image having a predetermined second fluorescence intensity based on the second processing condition; and generate a superimposed image by superimposing the first fluorescence region or the second fluorescence region that is identified, with a return-light image at a region in the return-light image corresponding to the first fluorescence region or the second fluorescence region, respectively, that is identified.
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公开(公告)号：US09518924B2
公开(公告)日：2016-12-13
申请号：US14499813
申请日：2014-09-29
Applicant: OLYMPUS CORPORATION
Inventor： Kei Kubo , Yasushige Ishihara , Hiromi Shida , Satoshi Takekoshi
CPC classification number: G01N21/6456 , A61B1/00009 , A61B1/0005 , A61B1/00055 , A61B1/043 , A61B1/045 , F04C2270/041 , G01N2201/124 , G06K9/4604 , G06T7/0012 , G06T2207/30004
Abstract: The invention provides a fluoroscopy apparatus including an image-capturing device that acquires a fluorescence image of a subject; a sensitivity adjusting portion that sets a sensitivity of the image-capturing device to fluorescence on the basis of a gradation value of the fluorescence image; a notifying portion that extracts a lesion part from the fluorescence image acquired by the image-capturing device with the sensitivity set by the sensitivity adjusting portion and presents it to an operator; and a display switching portion that displays the fluorescence image on a display unit when the sensitivity in the image-capturing device is equal to or less than a predetermined threshold and that presents information showing the existence of the lesion part on the notifying portion when the sensitivity is greater than the predetermined threshold.
Abstract translation: 本发明提供一种荧光透视装置，其包括获取被检体的荧光图像的图像捕获装置; 灵敏度调整部，其基于荧光图像的灰度值，将图像拍摄装置的感光度设定为荧光; 通知部，其以由灵敏度调节部设定的灵敏度从由摄像装置获取的荧光图像中提取病变部，并将其呈现给操作者; 以及显示切换部，当所述图像拍摄装置的灵敏度为规定阈值以下时，在所述显示部显示所述荧光图像，并且当所述灵敏度为灵敏度时，在所述通知部显示所述病变部的存在信息 大于预定阈值。
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公开(公告)号：US09417188B2
公开(公告)日：2016-08-16
申请号：US14197614
申请日：2014-03-05
Applicant: OLYMPUS CORPORATION
Inventor： Yasushige Ishihara
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/00039 , A61B1/043 , G06T5/00
Abstract: Provided is a fluorescence observation device including: a processor configured to: extract, as a candidate region of interest, a region in a corrected fluorescence image that has a gradation value larger than a gradation-value threshold, the gradation-value threshold being set based on an average of gradiation values, a standard deviation, a first coefficient, and a second coefficient; receive a result, inputted by an observer, as to whether a candidate region of interest displayed on a display is a result of right indicating a determination by the observer that the candidate region of interest is a region of interest or a result of wrong indicating a determination by the observer that the candidate region of interest is not a region of interest; and set at least one of the first coefficient and the second coefficient so as to reflect the result inputted by the observer.
Abstract translation: 本发明提供一种荧光观察装置，其特征在于，包括：处理器，其被配置为：提取具有比灰度值阈值大的灰度值的校正荧光图像中的区域作为候选区域，将所述灰度值阈值设定为 平均分数值，标准偏差，第一系数和第二系数; 接收由观察者输入的结果，显示在显示器上的候选兴趣区域是否是右侧的结果，表示观察者确定该关注的候选区域是感兴趣的区域，或指示错误的结果 观察员决定候选地区不是感兴趣的区域; 并且设置第一系数和第二系数中的至少一个，以便反映由观察者输入的结果。
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Patent Agency Ranking
公开(公告)号：US09332909B2
公开(公告)日：2016-05-10
申请号：US13942933
申请日：2013-07-16
Applicant: OLYMPUS CORPORATION
Inventor： Kei Kubo , Yasushige Ishihara , Hiromi Shida , Satoshi Takekoshi
CPC classification number: A61B5/0071 , A61B1/00009 , A61B1/043 , A61B1/0638 , A61B1/0646
Abstract: Provided is a fluoroscopy apparatus including a fluorescence-image generating portion that generates a fluorescence image; an identifying portion that identifies a position of a high-luminance region in the fluorescence image; a storage portion that stores the position of the high-luminance region; a detecting portion that detects an amount of change in a physical quantity, which can possibly act as a cause of changes in a property of the high-luminance region, starting from a time at which the position of the high-luminance region is identified by the identifying portion; a confidence-level calculating portion that calculates a confidence level of the property of the high-luminance region based on the detected amount of change; and a display-image generating portion that generates a display image in which the display mode at the position of the high-luminance region is set in accordance with the confidence level.
Abstract translation: 本发明提供一种荧光透视设备，包括产生荧光图像的荧光图像产生部分; 识别部，其识别所述荧光图像中的高亮度区域的位置; 存储部，其存储高亮度区域的位置; 检测部分，其从高亮度区域的位置的时间开始，从高亮度区域的位置开始，检测出物理量的变化量，其可能充当高亮度区域的性质变化的原因， 识别部分; 置信度计算部，其基于检测出的变化量来计算高亮度区域的属性的置信度; 以及显示图像生成部，其生成根据置信水平设定高亮度区域的位置的显示模式的显示图像。
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公开(公告)号：US08693802B2
公开(公告)日：2014-04-08
申请号：US13834395
申请日：2013-03-15
Applicant: Olympus Corporation
Inventor： Toshiaki Watanabe , Yasushige Ishihara
IPC: G06K9/00
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , G01N21/6454 , G01N21/6456 , G01N21/6486 , G06T5/009 , H04N5/2351
Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.
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公开(公告)号：US20130201320A1
公开(公告)日：2013-08-08
申请号：US13834549
申请日：2013-03-15
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki Watanabe , Yasushige Ishihara
IPC: H04N5/235
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , G01N21/6454 , G01N21/6456 , G01N21/6486 , G06T5/009 , H04N5/2351
Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.
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公开(公告)号：US20130200275A1
公开(公告)日：2013-08-08
申请号：US13834898
申请日：2013-03-15
Applicant: OLYMPUS CORPORATION
Inventor： Toshiaki Watanabe , Yasushige Ishihara
CPC classification number: G01N21/64 , A61B1/00009 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , G01N21/6454 , G01N21/6456 , G01N21/6486 , G06T5/009 , H04N5/2351
Abstract: A fluoroscopy apparatus including: an illumination unit having a light source radiating illumination light and excitation light onto an observation target, a fluorescence-imaging unit acquiring a fluorescence image by imaging fluorescence generated at the observation target by the excitation light, a white-light-imaging unit acquiring a reference image by imaging light returning from the observation target by the illumination light, and an image-correction unit obtaining a correction fluorescence image by raising the luminance value of the fluorescence image to the power of a reciprocal of a first and second exponent obtained by a power approximation of a distance characteristic of luminance versus observation distance, for the fluorescence image, and that obtains a corrected fluorescence image by dividing the correction fluorescence image by the correction reference image.
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20.发明授权Apparatus, method and operating method of apparatus for excluding non-target-region of fluorescence 有权用于排除非目标区荧光的装置的方法和操作方法公开(公告)号：US09519967B2
公开(公告)日：2016-12-13
申请号：US14312956
申请日：2014-06-24
Applicant: OLYMPUS CORPORATION
Inventor： Hiromi Shida , Yasushige Ishihara , Satoshi Takekoshi , Kei Kubo
CPC classification number: G06T7/0014 , A61B1/00009 , A61B1/043 , G02B21/16 , G02B23/2461 , G02B23/2484 , G06K9/46 , G06K2009/4666
Abstract: Fluorescence generated at a lesion is distinguished from fluorescence generated at portions other than the lesion, and thus, observation is performed by using only the fluorescence generated at the lesion. Provided is a fluorescence observation apparatus including a light radiating portion that radiates excitation light onto an examination subject; a fluorescence-distribution acquiring portion that acquires an intensity distribution of fluorescence generated at the examination subject due to irradiation with the excitation light from the light radiating portion; and a non-target-region excluding portion that, in the fluorescence-intensity distribution acquired by the fluorescence-distribution acquiring portion, excludes regions in which a spectrum in a specific wavelength band has changed due to a specific biological component whose concentration in a lesion is lower than in other portions.
Abstract translation: 在损伤处产生的荧光与病变以外的部分产生的荧光不同，因此仅使用在病变处产生的荧光进行观察。 本发明提供一种荧光观察装置，其包括将激发光照射到检查对象上的光照射部， 荧光分布获取部分，其获取由于来自所述光辐射部分的激发光的照射而在所述检查对象产生的荧光的强度分布; 以及在由荧光分布获取部获取的荧光强度分布中排除由特定生物成分在特定波长带中的光谱变化的区域的非靶区域排除部分， 低于其他部分。
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