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公开(公告)号：US06613873B1
公开(公告)日：2003-09-02
申请号：US09337304
申请日：1999-06-21
IPC分类号： A61K3800
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2535/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.
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公开(公告)号：US06414112B1
公开(公告)日：2002-07-02
申请号：US08686114
申请日：1996-07-24
IPC分类号： A61K3800
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2535/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.
摘要翻译： 称为肽核酸的新一类化合物比相应的DNA链更强地结合互补DNA和RNA链，并表现出增加的序列特异性和结合亲和力。 本发明的肽核酸包含选自天然存在的核碱基和连接到聚酰胺主链上的非天然存在的核碱基的配体。 本发明的一些PNA还含有C1-C8烷基胺侧链。
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公开(公告)号：US06395474B1
公开(公告)日：2002-05-28
申请号：US08108591
申请日：1993-11-22
IPC分类号： C12Q168
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译： 称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。 肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。
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公开(公告)号：US07378485B2
公开(公告)日：2008-05-27
申请号：US10154890
申请日：2002-05-23
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译： 称为肽核酸的新一类化合物比相应的DNA更强地结合互补的ssDNA和RNA链。 肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。
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15.发明申请IDENTIFICATION OF PHOSPHORYLATION SITES IN POLYPEPTIDES BY EMPLOYMENT OF URANYL PHOTOCLEAVAGE 审中-公开通过实施乌克兰电影鉴定多糖中的磷酸化位点公开(公告)号：US20100144044A1
公开(公告)日：2010-06-10
申请号：US12517164
申请日：2007-12-07
CPC分类号： G01N33/6803 , C07K14/4732 , G01N33/6842
摘要： The present invention relates to a method of cleaving a polypeptide at one or more phosphorylated residues. Said cleavage is induced by irradiation and is dependent on the presence of uranyl. The method is useful for analysis of phosphoproteoms and also for protein purification. The method also relates to a method of protein purification, wherein the phosphorylated protein is immobilized on a column said immobilization being dependent on uranyl.
摘要翻译： 本发明涉及在一个或多个磷酸化残基处切割多肽的方法。 所述切割是通过照射诱导的，并且取决于铀酰的存在。 该方法可用于磷酸化蛋白的分析和蛋白质纯化。 该方法还涉及蛋白质纯化的方法，其中将磷酸化蛋白质固定在所述固定化依赖于铀酰的柱上。
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