公开(公告)号：US08035016B2

公开(公告)日：2011-10-11

申请号：US12555609

申请日：2009-09-08

申请人： Earl J. Bergey ,  Adela Bonoiu ,  Supriya Mahajan ,  Paras N. Prasad ,  Indrajit Roy ,  Stanley A. Schwartz ,  Ken-Tye Yong

发明人： Earl J. Bergey ,  Adela Bonoiu ,  Supriya Mahajan ,  Paras N. Prasad ,  Indrajit Roy ,  Stanley A. Schwartz ,  Ken-Tye Yong

IPC分类号： A61P43/00 ,  C12N15/113

CPC分类号： C12N15/111 ,  A61K9/5115 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  Y10S977/773

摘要： Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.

摘要翻译： 提供了用于抑制一种或多种靶基因表达的方法和组合物。 组合物含有可通过与表面官能化金纳米棒（GNR）静电复合的RNA干扰（RNAi）抑制靶基因表达的RNA多核苷酸。 RNA多核苷酸不共价结合表面官能化的GNRs。 该方法涉及抑制个体中靶基因的表达。 该方法通过向个体施用有效量的含有可以通过RNAi抑制靶基因表达的RNA多核苷酸（例如siRNA）静电复合的表面官能化GNR的组合物来进行。 siRNA不与表面官能化的GNR共价结合。

公开(公告)号：US20160034528A1

公开(公告)日：2016-02-04

申请号：US14775329

申请日：2013-03-15

申请人： Indrajit ROY ,  Feng LIU ,  Vanish TALWAR ,  Shimin CHEN ,  Jichuan CHANG ,  Parthasarathy RANGANATHAN ,  HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

发明人： Indrajit Roy ,  Feng Liu ,  Vanish Talwar ,  Shimin Chen ,  Jichuan Chang ,  Parthasarathy Ranganathan

IPC分类号： G06F17/30

CPC分类号： G06F16/245 ,  G06F9/5005 ,  G06F9/5066 ,  G06F16/21 ,  G06F16/24554 ,  G06F16/283

摘要： A technique includes receiving a user input in an array-oriented database. The user input indicates a database operation and processing a plurality of chunks of data stored by the database to perform the operation. The processing in dudes selectively distributing the processing of the plurality of chunks between a first group of at least one central processing unit and a second group of at least one co-processor.

摘要翻译： 一种技术包括在面向数组的数据库中接收用户输入。 用户输入指示数据库操作并处理由数据库存储的多个数据块以执行操作。 所述处理在所述至少一个中央处理单元的第一组和至少一个协处理器的第二组之间选择性地分布所述多个块的处理。

公开(公告)号：US20140019490A1

公开(公告)日：2014-01-16

申请号：US13549112

申请日：2012-07-13

申请人： Indrajit Roy ,  Alvin Au Young ,  Vanish Talwar ,  Michael Mihn-Jong Lee

发明人： Indrajit Roy ,  Alvin Au Young ,  Vanish Talwar ,  Michael Mihn-Jong Lee

IPC分类号： G06F17/30

CPC分类号： G06F17/30286 ,  G06F17/30073 ,  G06F17/30321 ,  G06F17/30587 ,  G06F17/30958

摘要： Examples of the present disclosure may include methods, systems, and computer readable media with executable instructions. An example method for event processing for graph-structured data can include storing graph structured data. The graph structured data includes a plurality of vertex, edge, and/or property graph elements. The example method further includes defining a first graph view of a characteristic of vertex, edge, and/or property graph elements. A subgraph is determined as a subset of the plurality of vertex, edge, and/or property graph elements that have the characteristic of vertex, edge, and/or property graph elements defined by the first graph view. The vertex, edge, and/or property graph elements of the subgraph are processed responsive to a predefined event that occurs on at least one of the vertex, edge, and/or property graph elements of the subgraph.

摘要翻译： 本公开的示例可以包括具有可执行指令的方法，系统和计算机可读介质。 用于图形结构化数据的事件处理的示例方法可以包括存储图形结构化数据。 图形结构化数据包括多个顶点，边缘和/或属性图形元素。 示例性方法还包括定义顶点，边缘和/或属性图表元素的特征的第一图形视图。 子图被确定为具有由第一图形视图定义的顶点，边缘和/或属性图形元素的特征的多个顶点，边缘和/或属性图形元素的子集。 响应于发生在子图的顶点，边缘和/或属性图表元素中的至少一个上的预定义事件来处理子图的顶点，边缘和/或属性图形元素。

公开(公告)号：US09015721B2

公开(公告)日：2015-04-21

申请号：US13562248

申请日：2012-07-30

申请人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

发明人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert ,  Parthasarathy Ranganathan

IPC分类号： G06F9/46 ,  G06F9/50

CPC分类号： G06F9/5088 ,  G06F9/4881 ,  G06F9/5066

摘要： A plurality of array partitions are defined for use by a set of tasks of the program run-time. The array partitions can be determined from one or more arrays that are utilized by the program at run-time. Each of the plurality of computing devices are assigned to perform one or more tasks in the set of tasks. By assigning each of the plurality of computing devices to perform one or more tasks, an objective to reduce data transfer amongst the plurality of computing devices can be implemented.

摘要翻译： 定义多个阵列分区以供程序运行时的一组任务使用。 阵列分区可以从程序在运行时使用的一个或多个数组确定。 分配多个计算设备中的每一个以执行该组任务中的一个或多个任务。 通过分配多个计算设备中的每一个来执行一个或多个任务，可以实现减少多个计算设备之间的数据传输的目的。

公开(公告)号：US08819078B2

公开(公告)日：2014-08-26

申请号：US13549112

申请日：2012-07-13

申请人： Indrajit Roy ,  Alvin AuYoung ,  Vanish Talwar ,  Michael Mihn-Jong Lee

发明人： Indrajit Roy ,  Alvin AuYoung ,  Vanish Talwar ,  Michael Mihn-Jong Lee

IPC分类号： G06F17/30

CPC分类号： G06F17/30286 ,  G06F17/30073 ,  G06F17/30321 ,  G06F17/30587 ,  G06F17/30958

摘要： Examples of the present disclosure may include methods, systems, and computer readable media with executable instructions. An example method for event processing for graph-structured data can include storing graph structured data. The graph structured data includes a plurality of vertex, edge, and/or property graph elements. The example method further includes defining a first graph view of a characteristic of vertex, edge, and/or property graph elements. A subgraph is determined as a subset of the plurality of vertex, edge, and/or property graph elements that have the characteristic of vertex, edge, and/or property graph elements defined by the first graph view. The vertex, edge, and/or property graph elements of the subgraph are processed responsive to a predefined event that occurs on at least one of the vertex, edge, and/or property graph elements of the subgraph.

摘要翻译： 本公开的示例可以包括具有可执行指令的方法，系统和计算机可读介质。 用于图形结构化数据的事件处理的示例方法可以包括存储图形结构化数据。 图形结构化数据包括多个顶点，边缘和/或属性图形元素。 示例性方法还包括定义顶点，边缘和/或属性图表元素的特征的第一图形视图。 子图被确定为具有由第一图形视图定义的顶点，边缘和/或属性图形元素的特征的多个顶点，边缘和/或属性图形元素的子集。 响应于发生在子图的顶点，边缘和/或属性图表元素中的至少一个上的预定义事件来处理子图的顶点，边缘和/或属性图形元素。

公开(公告)号：US20140025415A1

公开(公告)日：2014-01-23

申请号：US13554891

申请日：2012-07-20

申请人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert

发明人： Shivaram Venkataraman ,  Indrajit Roy ,  Mehul A. Shah ,  Robert Schreiber ,  Nathan Lorenzo Binkert

IPC分类号： G06Q10/06

CPC分类号： G06Q10/06

摘要： A continuing analytics method includes distributing continuous analytics tasks among a number of workers. The workers execute the tasks on data elements stored in a distributed data storage system. Executing a task changes the data elements. In response to the change, a worker that executed a task invokes an update to the data storage system. The worker then increments a version number related to the changed data element, updates the data elements, and notifies other workers of the updated data element.

摘要翻译： 持续的分析方法包括在多个工作人员之间分配连续的分析任务。 工作人员对存储在分布式数据存储系统中的数据元素执行任务。 执行任务会更改数据元素。 响应于该更改，执行任务的工作人员调用对数据存储系统的更新。 然后，工作人员增加与更改的数据元素相关的版本号，更新数据元素，并向其他工作人员通知更新的数据元素。

公开(公告)号：US20130246731A1

公开(公告)日：2013-09-19

申请号：US13421651

申请日：2012-03-15

申请人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

发明人： Michael Mihn-Jong Lee ,  Indrajit Roy ,  Vanish Talwar ,  Alvin AuYoung ,  Parthasarathy Ranganathan

IPC分类号： G06F12/02

CPC分类号： G06F12/0284

摘要： In a method of implementing a graph storage system, the graph storage system is stored on a plurality of computing systems. A global address space is provided for distributed graph storage. The global address space is managed with graph allocators, in which a graph allocator allocates space from a block of the distributed global memory in order to store a plurality of graphs.

摘要翻译： 在实现图形存储系统的方法中，图形存储系统被存储在多个计算系统上。 为分布式图形存储提供了全局地址空间。 全局地址空间由图形分配器管理，其中图形分配器从分布式全局存储器的块分配空间以存储多个图形。

公开(公告)号：US20130110781A1

公开(公告)日：2013-05-02

申请号：US13285755

申请日：2011-10-31

申请人： Wojciech Golab ,  Nathan Lorenzo Binkert ,  Indrajit Roy ,  Mehul A. Shah ,  Bruce Walker

发明人： Wojciech Golab ,  Nathan Lorenzo Binkert ,  Indrajit Roy ,  Mehul A. Shah ,  Bruce Walker

IPC分类号： G06F7/00

CPC分类号： G06F16/275

摘要： An embodiment provides a method for server replication and transaction commitment. The method includes receiving a transaction from a client node at one or more memory nodes, each memory node comprising a number of replicas, and determining, for each one of the replicas, whether the replica is able to commit the transaction. The method also includes sending a response from each of the replicas to a consensus node, wherein the consensus node is configured to record whether the response is a commit response. The method further includes committing the transaction if, at each memory node, a quorum of the replicas is able to commit the transaction, and aborting the transaction otherwise.

摘要翻译： 实施例提供了用于服务器复制和事务承诺的方法。 该方法包括从一个或多个存储器节点处的客户端节点接收事务，每个存储器节点包括多个副本，并且针对每个副本确定副本是否能够提交事务。 该方法还包括将来自每个副本的响应发送到共享节点，其中，所述共享节点被配置为记录所述响应是否是提交响应。 该方法还包括提交交易，如果在每个存储节点处，副本的法定人数能够提交交易，否则中止该交易。

公开(公告)号：US20130110774A1

公开(公告)日：2013-05-02

申请号：US13285884

申请日：2011-10-31

申请人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

发明人： Mehul A. Shah ,  Wojciech Golab ,  Indrajit Roy ,  Nathan Lorenzo Binkert ,  Stavros Harizopoulos

IPC分类号： G06F7/00

CPC分类号： G06F11/2035 ,  G06F11/1425 ,  G06F11/1474 ,  G06F11/1658 ,  G06F11/1666 ,  G06F11/183 ,  G06F11/2023 ,  G06Q10/10

摘要： An embodiment provides a system and method for transaction commitment and replication. The method includes receiving a minitransaction from a client node at one or more memory nodes, wherein each memory node includes a number of replicas. The minitransaction is a type of transaction which atomically executes any combination of reading, comparing, and writing to any of a number of memory locations. The method also includes determining, for a leader of the replicas within a memory node, whether the leader is able to commit the minitransaction and stabilizing state changes of the minitransaction within a transaction log using a consensus procedure to update the replicas. The method further includes committing the minitransaction if, at each memory node, a quorum of the replicas is able to stabilize the minitransaction, or aborting the minitransaction otherwise.

摘要翻译： 一个实施例提供了用于事务承诺和复制的系统和方法。 该方法包括从一个或多个存储器节点处的客户端节点接收最小的转移，其中每个存储器节点包括多个副本。 minitransaction是一种事务，它以原子方式执行读取，比较和写入任意多个内存位置的任何组合。 该方法还包括针对内存节点内的副本的领导者，确定领导者是否能够使用协商一致的过程提交事务日志中的最小交易的最小交易和稳定状态变化来更新副本。 该方法还包括：在每个存储节点处，复制品的法定人数能够稳定最小化交易，或者中止其中的小交易。

公开(公告)号：US20110225425A1

公开(公告)日：2011-09-15

申请号：US12721576

申请日：2010-03-11

申请人： Ramakrishna R. Kotla ,  Indrajit Roy

发明人： Ramakrishna R. Kotla ,  Indrajit Roy

IPC分类号： H04L9/32

CPC分类号： H04L9/3236 ,  H04L9/3263 ,  H04L2209/38

摘要： A trusted read and write platform provides write-indisputability and read-undeniability for a distributed application. The platform is implemented at each node of the distributed application using a trusted platform module. To provide write-indisputability, the read and write platform of a node may generate a proof that is signed by the platform module and sent with a purportedly written result. The proof is decrypted using a public key associated with the platform module and includes indicators of the process taken by the read and write platform to write the result. To provide read-undeniability, the read and write platform may bind a key to a state of the platform module. A result to be read at the read and write platform is encrypted using the key and can only be decrypted when the read and write platform updates its state to the bound state.

摘要翻译： 可信赖的读写平台为分布式应用程序提供了无可争议的读取和不可否认性。 该平台使用可信平台模块在分布式应用程序的每个节点上实现。 为了提供写入无差别性，节点的读取和写入平台可以生成由平台模块签名并以所谓的书面结果发送的证明。 该证明使用与平台模块相关联的公开密钥进行解密，并包括读写平台所采用的写入结果的指示符。 为了提供读不可否认性，读写平台可以将键绑定到平台模块的状态。 在读写平台上读取的结果是使用密钥加密的，只有当读写平台将其状态更新到绑定状态时才能被解密。