利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

80 条记录 (耗时 0.028 秒)

    Laminated osmotic system for dispensing beneficial agent
    16.
    发明授权
    Laminated osmotic system for dispensing beneficial agent 失效
    用于分配有益剂的层压渗透系统

    公开(公告)号：US4014334A

    公开(公告)日：1977-03-29

    申请号：US654194

    申请日：1976-02-02

    申请人： Felix Theeuwes ,  Atul D. Ayer

    发明人： Felix Theeuwes ,  Atul D. Ayer

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61M31/00

    CPC分类号： A61K9/0004 ,  A61F9/0017

    摘要： An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a semipermeable, polymeric material that is permeable to the passage of an external fluid and maintains its physical and chemical integrity in the environment of use, and one consisting of a semipermeable polymeric material that is permeable to the passage of the fluid, substantially impermeable to the passage of agent and maintains its physical and chemical integrity in the presence of agent. The compartment comprises an active agent that is either soluble in the external fluid and exhibits an osmotic pressure gradient across the laminate against the fluid, or the agent has limited solubility in the fluid and it is mixed with an osmotically effective compound that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid. In operation, agent is released from the system by fluid being imbibed through the laminate into the compartment at a rate controlled by the permeability of the laminate and the osmotic pressure gradient across the laminate producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了一种用于将有益剂递送到使用环境的渗透系统。 该系统包括围绕隔室的层压板，并具有通过层压板的通道，用于将隔离物释放。 层压体包括至少两层; 一种由可渗透外部流体通道并在使用环境中保持其物理和化学完整性的半透性聚合材料组成，并且由可渗透流体的半透性聚合物材料组成，基本上 通过试剂不渗透，并在试剂存在下保持其物理和化学完整性。 隔室包含可溶于外部流体的活性剂，并且表现出横跨该层压体的流体的渗透压梯度，或者该试剂在流体中具有有限的溶解度，并且与渗透性有效的化合物混合，该化合物可溶于 并且表现出跨过层压体抵抗流体的渗透压梯度。 在操作中，通过流体通过层压体被吸收到隔室中的剂量从层压体的渗透性控制的速率和穿过层压体的渗透压梯度产生包含溶液的试剂或含化合物的溶液 任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

    Osmotic system having laminar arrangement for programming delivery of active agent
    17.
    发明授权
    Osmotic system having laminar arrangement for programming delivery of active agent 失效
    渗透系统具有用于编程递送活性剂的层流布置

    公开(公告)号：US4008719A

    公开(公告)日：1977-02-22

    申请号：US654195

    申请日：1976-02-02

    申请人： Felix Theeuwes ,  Atul D. Ayer

    发明人： Felix Theeuwes ,  Atul D. Ayer

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61F9/0017 ,  A61K9/0004

    摘要： An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a lamina consisting of a material or of a multiplicity of materials to provide a laminated wall that is permeable to agents and maintains its integrity during the delivery of agent. The compartment contains an agent that is soluble in an external fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the agent has limited solubility in the fluid and is mixed with an osmotically effective compound soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, agent is released from the system by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了用于递送试剂的渗透系统。 该系统包括围绕隔室的壁，并且具有用于从隔室输送药剂的通道。 该壁由薄片形成，该薄片包括由层叠布置的多种材料组成的薄片，该薄片由材料或多种材料组成的薄片组成，以提供层叠壁，所述层压壁可在试剂的输送期间可渗透并保持其完整性 代理商 隔间含有一种可溶于外部流体的试剂，并且在整个壁上表现出与流体相对的渗透压梯度，或者该试剂在流体中的溶解度有限，并且与可溶于流体的渗透性有效化合物混合并显示出渗透性 横跨壁的压力梯度相对于流体。 在操作中，通过流体通过壁被吸入到隔室中的流体以由壁的渗透性和穿过壁的渗透压梯度控制的速率从系统释放，产生含溶液的试剂或含化合物的溶液 任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

    Process for manufacturing device with dispersion zone
    18.
    发明授权
    Process for manufacturing device with dispersion zone 失效
    具有分散区制造装置的方法

    公开(公告)号：US4285987A

    公开(公告)日：1981-08-25

    申请号：US90492

    申请日：1979-11-01

    申请人： Atul D. Ayer ,  Felix Theeuwes

    发明人： Atul D. Ayer ,  Felix Theeuwes

    IPC分类号： A61K9/00 ,  A61M7/00

    CPC分类号： A61K9/0004

    摘要： An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.

    摘要翻译： 公开了用于分配有益试剂的渗透系统。 该系统包括（1）半透性材料的第一壁，该第一壁围绕包含药物制剂的隔室，并且具有通过所述壁的通道，用于从所述隔间释放剂，（2）位于远离所述第一壁的第二壁，所述第二壁 第二壁是围绕第一壁延伸的微孔或水凝胶材料，以及（3）介于第一和第二壁之间的分配区，并且初始地容纳可溶于进入系统的外部流体的化合物。 在操作中，通过流体通过第二壁将流体从系统中分配到进入区域中的流体进一步从第一壁吸入到隔室中，该隔室形成通过通道被释放到该区域中的溶液，然后通过 第二个墙壁到系统的外部。

    Osmotic system with laminated wall comprising structurally different semipermeable lamina
    19.
    发明授权
    Osmotic system with laminated wall comprising structurally different semipermeable lamina 失效
    具有层压壁的渗透系统包括结构不同的半透膜

    公开(公告)号：US4116241A

    公开(公告)日：1978-09-26

    申请号：US750773

    申请日：1976-12-15

    申请人： Felix Theeuwes ,  Atul D. Ayer

    发明人： Felix Theeuwes ,  Atul D. Ayer

    IPC分类号： A61F9/00 ,  A61K9/00 ,  A61K9/24 ,  A61K9/44

    CPC分类号： A61K9/0004 ,  A61F9/0017

    摘要： An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a semipermeable, polymeric material that is permeable to the passage of an external fluid and maintains its physical and chemical integrity in the environment of use, and one consisting of a semipermeable polymeric material that is permeable to the passage of fluid, substantially impermeable to the passage of agent and maintains its physical and chemical integrity in the presence of agent. The compartment comprises an active agent that is either soluble in the external fluid and exhibits an osmotic pressure gradient across the laminate against the fluid, or the agent has limited solubility in the fluid and it is mixed with an osmotically effective compound that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid. In operation, agent is released from the system by fluid being imbibed through the laminate into the compartment at a rate controlled by the permeability of the laminate and the osmotic pressure gradient across the laminate producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了一种用于将有益剂递送到使用环境的渗透系统。 该系统包括围绕隔室的层压板，并具有通过层压板的通道，用于将隔离物释放。 层压体包括至少两层; 一种由可渗透外部流体通道并在使用环境中保持其物理和化学完整性的半透性聚合材料组成，并且由可渗透流体的半透性聚合材料构成，基本上不渗透 代理人的通过，并在代理人的存在下保持其物理和化学完整性。 隔室包含可溶于外部流体的活性剂，并且表现出横跨该层压体的流体的渗透压梯度，或者该试剂在流体中具有有限的溶解度，并且与渗透性有效的化合物混合，该化合物可溶于 并且表现出跨过层压体抵抗流体的渗透压梯度。 在操作中，通过流体通过层压体被吸收到隔室中的剂量从层压体的渗透性控制的速率和穿过层压体的渗透压梯度产生包含溶液的试剂或含化合物的溶液 任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

    Osmotic devices having composite walls
    20.
    发明授权
    Osmotic devices having composite walls 失效
    具有复合壁的渗透装置

    公开(公告)号：US4077407A

    公开(公告)日：1978-03-07

    申请号：US634859

    申请日：1975-11-24

    申请人： Felix Theeuwes ,  Atul D. Ayer

    发明人： Felix Theeuwes ,  Atul D. Ayer

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61M29/04 ,  A61M31/00

    CPC分类号： A61K9/0036 ,  A61K9/0004

    摘要： An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding a compartment and has a passageway through the wall for releasing the agent. The wall is formed of a multiplicity of materials comprising a material permeable to an external fluid and substantially impermeable to agent and at least one additional material selected from a material that imparts stability to the wall, enhances the permeability of the wall to fluids, or aids in forming the wall. The compartment comprises an active agent that exhibits an osmotic pressure gradient against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, to produce a solution containing agent that is released through the passageway at a controlled and continuous rate over a prolonged period of time.

    摘要翻译： 公开了用于递送活性剂的渗透装置。 该装置包括围绕隔室的壁，并且具有通过壁的通道用于释放试剂。 该壁由多种材料形成，包括可渗透外部流体的材料并且基本上不可渗透到试剂和至少一种附加材料，其选自赋予壁的稳定性的材料，增强壁对流体或助剂的渗透性 在形成墙。 所述隔室包含对外部流体显示渗透压梯度的活性剂，或者所述试剂与渗透压梯度相对于所述流体呈现渗透压的化合物混合。 通过流体通过壁被吸入到隔室中的剂量通过壁的渗透性和穿过壁的渗透压梯度控制的速率从装置释放，以产生溶液包含试剂，其通过通道在受控的 并持续延长时间。