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38 条记录 (耗时 0.039 秒)

    Tripyridyl carboxamide orexin receptor antagonists
    11.
    发明授权
    Tripyridyl carboxamide orexin receptor antagonists 有权
    三吡啶甲酰胺食欲肽受体拮抗剂

    公开(公告)号：US08349872B2

    公开(公告)日：2013-01-08

    申请号：US12536079

    申请日：2009-08-05

    申请人： Paul J. Coleman ,  Swati P. Mercer ,  Thomas S. Reger ,  Anthony J. Roecker

    发明人： Paul J. Coleman ,  Swati P. Mercer ,  Thomas S. Reger ,  Anthony J. Roecker

    IPC分类号： A61K31/4425 ,  C07D213/40

    CPC分类号： C07D213/82

    摘要： The present invention is directed to tripyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的三吡啶羧酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS
    17.
    发明申请
    2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS 审中-公开
    2-ALKYL PIPERIDINE MGLUR5受体调节剂

    公开(公告)号：US20120040998A1

    公开(公告)日：2012-02-16

    申请号：US13265672

    申请日：2010-04-22

    申请人： Swati P. Mercer ,  Anthony J. Roecker ,  Theresa Williams ,  Xu-Fang Zhang

    发明人： Swati P. Mercer ,  Anthony J. Roecker ,  Theresa Williams ,  Xu-Fang Zhang

    IPC分类号： A61K31/454 ,  A61K31/4545 ,  A61P25/18 ,  C07D417/14 ,  C07D413/04 ,  A61P25/00 ,  C07D413/14 ,  A61K31/497

    CPC分类号： C07D413/04 ,  C07D413/14

    摘要： The present invention is directed to 2-alkylpiperidines which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

    摘要翻译： 本发明涉及作为代谢型谷氨酸受体，特别是mGluR5受体的正性变构调节剂的2-烷基哌啶，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍，以及代谢型谷氨酸受体是 涉及。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

    Tetrahydronapthyridine Orexin Receptor Antagonists
    18.
    发明申请
    Tetrahydronapthyridine Orexin Receptor Antagonists 审中-公开
    四氢萘啶氧化蛋白受体拮抗剂

    公开(公告)号：US20120101106A1

    公开(公告)日：2012-04-26

    申请号：US13382447

    申请日：2010-07-01

    申请人： Swati P. Mercer ,  Anthony J. Roecker

    发明人： Swati P. Mercer ,  Anthony J. Roecker

    IPC分类号： A61K31/4985 ,  A61P3/04 ,  A61P25/00 ,  C07D471/04 ,  A61K31/4375

    CPC分类号： A61K31/27 ,  C07D471/04

    摘要： The present invention is directed to tetrahydronapthyridine and tetrahydropyridopyrazine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的四氢萘吡啶和四氢吡啶并吡嗪化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS
    19.
    发明申请
    PYRAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS 审中-公开
    吡咯烷酰胆碱受体拮抗剂

    公开(公告)号：US20120065205A1

    公开(公告)日：2012-03-15

    申请号：US13320431

    申请日：2010-05-26

    申请人： Swati P. Mercer ,  Anthony J. Roecker

    发明人： Swati P. Mercer ,  Anthony J. Roecker

    IPC分类号： A61K31/497 ,  A61P3/04 ,  A61K31/5377 ,  A61P25/00 ,  C07D401/14 ,  C07D413/14

    CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D401/12

    摘要： The present invention is directed to pyrazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡嗪甲酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。