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公开(公告)号：US20110195957A1
公开(公告)日：2011-08-11
申请号：US13089677
申请日：2011-04-19
申请人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
IPC分类号： A61K31/551 , C07D413/14 , C07D495/04 , C07D403/14 , C07D491/044 , C07D487/04 , A61P25/00 , A61P25/18 , A61P25/16 , A61P25/08 , A61P29/00 , A61P3/04
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20080132490A1
公开(公告)日：2008-06-05
申请号：US11998812
申请日：2007-11-30
申请人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Swati P. Mercer , Anthony J. Roecker
IPC分类号： A61K31/551 , A61P43/00 , C07D243/06
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20110201591A1
公开(公告)日：2011-08-18
申请号：US13124568
申请日：2009-10-26
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mamio Christa Mattern , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mamio Christa Mattern , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker
IPC分类号： A61K31/497 , C07D401/14 , C07D213/81 , C07D401/04 , C07D401/12 , C07D417/14 , A61K31/444 , A61K31/4418 , A61K31/4439 , A61P3/04 , A61P25/00
CPC分类号： C07D401/04 , C07D213/81 , C07D401/12 , C07D401/14 , C07D417/14
摘要： The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的异烟酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08592457B2
公开(公告)日：2013-11-26
申请号：US13124568
申请日：2009-10-26
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mamio Christa Mattern , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mamio Christa Mattern , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker
IPC分类号： A61K31/4436 , C07D417/14
CPC分类号： C07D401/04 , C07D213/81 , C07D401/12 , C07D401/14 , C07D417/14
摘要： The present invention is directed to isonicotinamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的异烟酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08003797B2
公开(公告)日：2011-08-23
申请号：US12669909
申请日：2008-08-07
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
IPC分类号： C07D213/22 , C07D213/44
CPC分类号： C07D213/82 , A61K31/4427 , A61K31/4439 , A61K31/444 , C07D401/04 , C07D401/14
摘要： The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶羧酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20110301140A1
公开(公告)日：2011-12-08
申请号：US13197800
申请日：2011-08-04
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
IPC分类号： A61K31/541 , C07D401/14 , A61K31/4439 , C07D401/04 , A61K31/497 , C07D413/14 , A61P3/04 , A61K31/498 , C07D417/04 , A61P25/20 , A61K31/444 , A61K31/5377
CPC分类号： C07D213/82 , A61K31/4427 , A61K31/4439 , A61K31/444 , C07D401/04 , C07D401/14
摘要： The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶羧酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20100197652A1
公开(公告)日：2010-08-05
申请号：US12669909
申请日：2008-08-07
申请人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
发明人： Jeffrey M. Bergman , Paul J. Coleman , Mark E. Fraley , Swati P. Mercer , Thomas S. Reger , Anthony J. Roecker , Justin T. Steen
IPC分类号： A61K31/465 , C07D401/04 , A61K31/4709 , C07D213/82 , C07D401/10 , C07D401/14 , A61K31/501 , A61K31/498 , C07D413/04 , A61K31/5377 , A61K31/4545 , C07D417/04 , A61K31/541 , A61P3/04 , A61P25/00
CPC分类号： C07D213/82 , A61K31/4427 , A61K31/4439 , A61K31/444 , C07D401/04 , C07D401/14
摘要： The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶羧酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08703770B2
公开(公告)日：2014-04-22
申请号：US13126654
申请日：2009-10-26
IPC分类号： A61K31/5377 , A61K31/501 , C07D413/04 , C07D401/04
CPC分类号： A61K31/405 , A61K31/4439 , C07D333/66
摘要： The present invention is directed to pyridazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的哒嗪甲酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20120046289A1
公开(公告)日：2012-02-23
申请号：US13126654
申请日：2009-10-26
IPC分类号： A61K31/5377 , A61K31/501 , A61P25/20 , C07D403/04 , A61P3/04 , C07D413/14 , C07D401/04 , C07D413/04
CPC分类号： A61K31/405 , A61K31/4439 , C07D333/66
摘要： The present invention is directed to pyridazine carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的哒嗪甲酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08710076B2
公开(公告)日：2014-04-29
申请号：US13124901
申请日：2009-10-15
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , Anthony J. Roecker , John D. Schreier
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Izzat T. Raheem , Anthony J. Roecker , John D. Schreier
IPC分类号： A61K31/47 , C07D401/14
CPC分类号： A61K31/445 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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