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    METHODS AND SYSTEMS FOR GENETIC ANALYSIS
    11.
    发明申请
    METHODS AND SYSTEMS FOR GENETIC ANALYSIS 有权

    公开(公告)号：US20220275446A1

    公开(公告)日：2022-09-01

    申请号：US17747436

    申请日：2022-05-18

    Applicant: Personalis, Inc.

    Inventor： John West ,  Christian Haudenschild ,  Richard Chen

    IPC: C12Q1/6874 ,  C12Q1/6806 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00

    Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

    METHODS AND SYSTEMS FOR GENETIC ANALYSIS
    12.
    发明申请
    METHODS AND SYSTEMS FOR GENETIC ANALYSIS 有权

    公开(公告)号：US20220195520A1

    公开(公告)日：2022-06-23

    申请号：US17688072

    申请日：2022-03-07

    Applicant: Personalis, Inc.

    Inventor： John West ,  Christian Haudenschild ,  Richard Chen

    IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  C12Q1/6806

    Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

    METHODS AND SYSTEMS FOR GENETIC ANALYSIS
    13.
    发明申请
    METHODS AND SYSTEMS FOR GENETIC ANALYSIS 有权

    公开(公告)号：US20220098662A1

    公开(公告)日：2022-03-31

    申请号：US17548379

    申请日：2021-12-10

    Applicant: Personalis, Inc.

    Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Shujun Luo ,  Mark R. Pratt ,  John West

    IPC: C12Q1/6874 ,  G16B20/00 ,  G16B30/00 ,  G16B99/00 ,  G16B20/10 ,  G16B20/20 ,  G16B35/10 ,  C12Q1/6806

    Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

    METHODS AND SYSTEMS FOR GENOMIC ANALYSIS
    14.
    发明申请
    METHODS AND SYSTEMS FOR GENOMIC ANALYSIS 有权

    公开(公告)号：US20210193260A1

    公开(公告)日：2021-06-24

    申请号：US16952507

    申请日：2020-11-19

    Applicant: Personalis, Inc.

    Inventor： Jason Harris ,  Mark R. Pratt ,  John West ,  Richard Chen ,  Ming Li

    IPC: G16B30/00 ,  G06N3/12 ,  G16B20/00

    Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

    Methods and systems for genomic analysis
    16.
    发明授权
    Methods and systems for genomic analysis 有权

    公开(公告)号：US09727692B2

    公开(公告)日：2017-08-08

    申请号：US14871020

    申请日：2015-09-30

    Applicant: Personalis, Inc.

    Inventor： Jason Harris ,  Mark R. Pratt ,  John West ,  Richard Chen ,  Ming Li

    IPC: G06F19/22 ,  G06F15/00 ,  G06F19/18 ,  G06N3/12

    CPC classification number: G06F19/22 ,  C12Q1/68 ,  G06F19/18 ,  G06N3/126

    Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

    METHODS FOR ANALYZING GENOTYPES
    17.
    发明申请
    METHODS FOR ANALYZING GENOTYPES 审中-公开
    方法分析基因组

    公开(公告)号：US20160283484A1

    公开(公告)日：2016-09-29

    申请号：US15083058

    申请日：2016-03-28

    Applicant: Personalis, Inc.

    Inventor： Gemma L. CHANDRATILLAKE ,  Sarah K. Garcia ,  Richard Chen ,  Michael James Clark

    IPC: G06F17/30 ,  G06F19/18 ,  G06F19/28

    CPC classification number: G06F17/3053 ,  G06F17/30554 ,  G06F19/18 ,  G06F19/28

    Abstract: The disclosure provides methods and systems for analyzing genotype data. In some embodiments, a computer-implemented method comprises receiving data relating to one or more phenotypes of a subject or family members thereof, and ranking genes based on their association score with one or more phenotypes. Next, an output of the data is generated, the output comprising a comparison of the data based on the association score. The comparison can be in at least one of numeric and graphic form.

    Abstract translation: 本公开提供了分析基因型数据的方法和系统。 在一些实施方案中，计算机实现的方法包括接收与受试者或其家族成员的一种或多种表型有关的数据，以及基于其与一种或多种表型的关联评分对基因进行排序。 接下来，生成数据的输出，输出包括基于关联分数的数据的比较。 比较可以是数字和图形中的至少一种。

    METHODS AND SYSTEMS FOR GENETIC ANALYSIS
    18.
    发明申请
    METHODS AND SYSTEMS FOR GENETIC ANALYSIS 有权

    公开(公告)号：US20240425920A1

    公开(公告)日：2024-12-26

    申请号：US18824319

    申请日：2024-09-04

    Applicant: Personalis, Inc.

    Inventor： Gabor T. Bartha ,  Gemma Chandratillake ,  Richard Chen ,  Sarah Garcia ,  Hugo Yu Kor Lam ,  Mark R. Pratt ,  John West

    IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12Q1/6869 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/00 ,  G16B35/00 ,  G16B35/10 ,  G16B99/00 ,  G16C20/60

    Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

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