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公开(公告)号：US20210371453A1
公开(公告)日：2021-12-02
申请号：US17400938
申请日：2021-08-12
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , A61K47/64 , C07H3/06
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20210145957A1
公开(公告)日：2021-05-20
申请号：US17161119
申请日：2021-01-28
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Amardeep Singh Bhupender Bhalla , Robert G.K. Donald , Jianxin Gu , Kathrin Ute Jansen , Rajesh Kumar Kainthan , Lakshmi Khandke , Jin-Hwan Kim , Paul Liberator , Avvari Krishna Prasad , Mark Edward Ruppen , Ingrid Lea Scully , Suddham Singh , Cindy Xudong Yang
Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B. streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention also relates to immunogenic compositions comprising polysaccharide-protein conjugates, wherein the conjugates comprise a CP from GBS serotype IV and at least one additional serotype. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US10392420B2
公开(公告)日：2019-08-27
申请号：US14652723
申请日：2013-12-13
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , C07H3/06 , A61K47/64 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20190000953A1
公开(公告)日：2019-01-03
申请号：US16133021
申请日：2018-09-17
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K39/00
Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
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公开(公告)号：US10105431B2
公开(公告)日：2018-10-23
申请号：US15110634
申请日：2015-01-15
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
Abstract: The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides covalently linked to a carrier protein, processes for their preparation and immunogenic compositions and vaccines comprising them.
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Patent Agency Ranking
公开(公告)号：US12234259B2
公开(公告)日：2025-02-25
申请号：US18176631
申请日：2023-03-01
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , A61K39/09 , A61K39/095 , A61K47/64 , C07H3/06 , C07K14/22 , C07K14/315 , C07K14/34 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20240033367A1
公开(公告)日：2024-02-01
申请号：US18330144
申请日：2023-06-06
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
CPC classification number: A61K47/6415 , A61K39/092 , A61K47/646 , A61K2039/6037
Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I):
wherein:
A is a group (C═X)m wherein X is S or O and m is 0 or 1;
B is a bond, O, or CH2; and when m is 0, B can also be (C═O);
R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl.
The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.-
公开(公告)号：US11707529B2
公开(公告)日：2023-07-25
申请号：US16852697
申请日：2020-04-20
Applicant: Pfizer Inc.
Inventor： Jianxin Gu , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad , Yu-Ying Yang
CPC classification number: A61K47/6415 , A61K39/092 , A61K47/646 , A61K2039/6037 , A61K2039/627 , C07K1/1077
Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I):
wherein:
A is a group (C═X)m wherein X is S or O and m is 0 or 1;
B is a bond, O, or CH2; and when m is 0, B can also be (C═O);
R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl.
The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.-
公开(公告)号：US20220168410A1
公开(公告)日：2022-06-02
申请号：US17672126
申请日：2022-02-15
Applicant: Pfizer Inc.
Inventor： Robert G.K. Donald , Annaliesa Sybil Anderson , Laurent Oliver Chorro , Jianxin Gu , Jin-Hwan Kim , Srinivas Kodali , Jason Arnold Lotvin , Justin Keith Moran , Rosalind Pan , Avvari Krishna Prasad , Mark Edward Ruppen , Suddham Singh , Ling Chu , Scott Ellis Lomberk , Karen Kiyoko Takane , Nishith Merchant , Wei Chen
IPC: A61K39/108 , C08B37/00 , A61P31/04 , A61P37/04
Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
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公开(公告)号：US20220016229A1
公开(公告)日：2022-01-20
申请号：US17312185
申请日：2019-12-09
Applicant: Pfizer Inc.
Inventor： Avvari Krishna Prasad , Jianxin Gu , Jin-Hwan Kim , Suddham Singh
Abstract: The present invention relates to new glycoconjugates comprising Streptococcus pneumoniae capsular saccharide antigens and uses thereof. Glycoconjugates of the present invention will typically comprise 2 or more saccharides antigens conjugated to the same molecule of the protein carrier. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using immunogenic compositions comprising said novel glycoconjugates.
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