公开(公告)号：US20090028908A1

公开(公告)日：2009-01-29

申请号：US12187230

申请日：2008-08-06

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08 ,  A61P25/00

CPC分类号： A61K38/046 ,  A61K38/4893 ,  A61K2300/00

摘要： The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin component and a substance P component to a patient, thereby treating the neurogenic inflammation pain.

公开(公告)号：US07413742B2

公开(公告)日：2008-08-19

申请号：US11466244

申请日：2006-08-22

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08 ,  C07K14/00

CPC分类号： C07K14/33 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K2319/00

摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

公开(公告)号：US20070218085A1

公开(公告)日：2007-09-20

申请号：US11749461

申请日：2007-05-16

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K39/08

CPC分类号： A61K38/4893 ,  Y02A50/469 ,  Y10S514/937 ,  Y10S514/963

摘要： Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.

摘要翻译： 用于治疗精神疾病的方法包括向人类患者施用治疗有效量的神经毒素（例如A型肉毒毒素）的颅内给药。

公开(公告)号：US20060228780A1

公开(公告)日：2006-10-12

申请号：US11452570

申请日：2006-06-14

申请人： Mingjiang Luo ,  Hui Xiang ,  Yao Yu ,  Stephen Donovan

发明人： Mingjiang Luo ,  Hui Xiang ,  Yao Yu ,  Stephen Donovan

IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N15/74 ,  C07K14/33

CPC分类号： C07K14/33 ,  C12N1/20 ,  C12N9/52 ,  C12N9/6489 ,  C12P21/02 ,  C12Y304/24069

摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.

摘要翻译： 用于从APF发酵培养基中纯化肉毒毒素的色谱法和系统。

公开(公告)号：US20060216313A1

公开(公告)日：2006-09-28

申请号：US11446403

申请日：2006-06-02

申请人： Gregory Brooks ,  Stephen Donovan

发明人： Gregory Brooks ,  Stephen Donovan

IPC分类号： A61K39/08

CPC分类号： A61L31/148 ,  A61K9/0034 ,  A61K38/4893 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/40

摘要： Methods of treating a urethral stricture in a patient. The methods can include the step of administering an therapeutically effective amount of a botulinum toxin directly to a urethra of the patient, for example by use of a stent from which the botulinum toxin can elute or diffuse, thereby treating the urethra stricture.

摘要翻译： 治疗患者尿道狭窄的方法。 所述方法可以包括将治疗有效量的肉毒杆菌毒素直接施用于患者的尿道的步骤，例如通过使用肉毒杆菌毒素可以从其中洗脱或扩散的支架，从而治疗尿道狭窄。

公开(公告)号：US20060067929A1

公开(公告)日：2006-03-30

申请号：US11265953

申请日：2005-11-03

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K38/46 ,  A61K39/08

CPC分类号： C07K14/33 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K2319/00

摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

公开(公告)号：US20050260231A1

公开(公告)日：2005-11-24

申请号：US11192777

申请日：2005-07-29

申请人： Mitchell Brin ,  Stephen Donovan

发明人： Mitchell Brin ,  Stephen Donovan

IPC分类号： A61K38/12 ,  A61K38/48 ,  A61P35/00 ,  A61K39/08

CPC分类号： A61K38/4893 ,  A61K38/00

摘要： A method for treating a mammary gland disorder, including hyperplasic, hypertonic, cystic and/or neoplastic mammary gland tissue by local administration of a botulinum toxin to or to the vicinity of the afflicted breast tissue.

摘要翻译： 一种通过局部施用肉毒杆菌毒素向受影响的乳腺组织或其附近治疗乳腺疾病的方法，包括增生性，高渗性，囊性和/或肿瘤性乳腺组织。

公开(公告)号：US06767544B2

公开(公告)日：2004-07-27

申请号：US10114740

申请日：2002-04-01

申请人： Gregory F. Brooks ,  Stephen Donovan

发明人： Gregory F. Brooks ,  Stephen Donovan

IPC分类号： A61K3908

CPC分类号： A61L31/047 ,  A61K38/4893 ,  A61K45/06 ,  Y02A50/469 ,  Y10S514/814 ,  Y10S514/832

摘要： The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease.

公开(公告)号：US06743424B1

公开(公告)日：2004-06-01

申请号：US09706172

申请日：2000-11-02

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： A61K3851

CPC分类号： A61K38/4893

摘要： A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates the thyroid, thereby reducing a stimulatory effect upon thyroid hormone secretion. Methods for treating calcium metabolism disorders by local administration of a neurotoxin to modulate calcitonin secretion are also disclosed.

摘要翻译： 一种通过局部施用甲状腺毒素等神经毒素治疗甲状腺功能减退的方法，从而降低对甲状腺激素分泌的抑制作用。 通过局部施用神经毒素（例如肉毒杆菌毒素）治疗甲状腺功能亢进的方法，用于支配甲状腺的交感神经节，从而降低对甲状腺激素分泌的刺激作用。 还公开了通过局部施用神经毒素以调节降钙素分泌来治疗钙代谢紊乱的方法。

公开(公告)号：US06641820B1

公开(公告)日：2003-11-04

申请号：US09625098

申请日：2000-07-25

申请人： Stephen Donovan

发明人： Stephen Donovan

IPC分类号： C07K1900

CPC分类号： A61K38/4893 ,  A61K47/6415 ,  A61K47/642 ,  A61K48/00 ,  C07K7/22 ,  C07K14/33 ,  C07K2319/00

摘要： Methods for treating a bone tumor, in particular pain associated with bone tumor, by administration to a patient of a therapeutically effective amount of an agent are disclosed. The agent may include a clostridial neurotoxin component attached to a targeting moiety, wherein the targeting moiety is selected from the group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

摘要翻译： 公开了通过向患者施用治疗有效量的药物来治疗骨肿瘤，特别是与骨肿瘤相关的疼痛的方法。 所述试剂可以包括连接到靶向部分的梭菌神经毒素组分，其中所述靶向部分选自由神经元传递疼痛信号后可从神经元释放的透射化合物和与所述传播基本相似的化合物 化合物。