公开(公告)号：US09750849B2

公开(公告)日：2017-09-05

申请号：US15034668

申请日：2014-11-06

申请人： Henry Ralph Rawls ,  Ahsan Ullah Khan

发明人： Henry Ralph Rawls ,  Ahsan Ullah Khan

IPC分类号： A61L27/54 ,  A61L27/52 ,  A61L15/44 ,  A61C8/02 ,  A61F13/02 ,  A61K31/01 ,  A61K31/357

CPC分类号： A61L27/54 ,  A61C8/0006 ,  A61F13/0206 ,  A61K31/01 ,  A61K31/357 ,  A61L15/44 ,  A61L27/52 ,  A61L2300/20

摘要： Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material that is used to form a coating, layer, or bulk substance that can be a solid, a gel or a fluid. The oxygen-carrier is most conveniently prepared by oxidation of a precursor compound, the structure of which determines its thermal stability and thus how rapidly oxygen is released at any given temperature.

公开(公告)号：US20150359939A1

公开(公告)日：2015-12-17

申请号：US14833404

申请日：2015-08-24

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G. Matheny

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61N1/375 ,  A61L31/14 ,  A61L31/16 ,  A61L31/00 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61L27/3629 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/24 ,  A61F2002/0086 ,  A61F2210/0076 ,  A61K35/12 ,  A61K35/22 ,  A61K35/37 ,  A61K35/38 ,  A61K35/42 ,  A61K38/005 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3679 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L31/005 ,  A61L31/041 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/23 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/418 ,  A61L2300/434 ,  A61L2300/45 ,  A61L2300/64 ,  A61L2400/02 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/20 ,  A61N1/375 ,  A61N1/3752

摘要： A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.

公开(公告)号：US20150250916A1

公开(公告)日：2015-09-10

申请号：US14429813

申请日：2013-09-20

申请人： UNICHARM CORPORATION

发明人： Yuki Noda ,  Tatsuya Tamura ,  Akira Hashino ,  Toru Oba

IPC分类号： A61L15/20 ,  A61L15/42 ,  B32B37/14 ,  A61F13/84

CPC分类号： A61L15/20 ,  A61F13/15731 ,  A61F13/51104 ,  A61F13/51113 ,  A61F13/513 ,  A61F13/8405 ,  A61L15/42 ,  A61L2300/20 ,  A61L2300/21 ,  A61L2300/216 ,  B32B37/14 ,  B32B2307/726

摘要： An absorbent article includes a liquid-permeable top sheet, a liquid-impermeable back sheet, and an absorbent body arranged between the top sheet and the back sheet. An excretory orifice contact area of the liquid-permeable top sheet has an area containing a blood lubricity-imparting agent. The blood lubricity-imparting agent has a kinematic viscosity of 0.01-80 mm2/s at 40° C., a water hold percentage of 0.01-4.0 mass %, and a weight average molecular weight of less than 1,000. An amount of the blood lubricity-imparting agent on the clothing-side surface of the top sheet is greater than an amount of the blood lubricity-imparting agent on the skin-side surface of the top sheet at a location in the area containing the blood lubricity-imparting agent where the surfaces overlap in the thickness direction of the absorbent article.

摘要翻译： 吸收性物品包括透液性顶片，不透液性底片和布置在顶片和背片之间的吸收体。 透液性顶片的排泄孔接触面积具有包含血液润滑性赋予剂的区域。 血液润滑性赋予剂在40℃下的运动粘度为0.01-80mm 2 / s，保水率为0.01-4.0质量％，重均分子量小于1,000。 在顶片的衣服侧表面上的血液润滑性赋予剂的量大于在含有血液的区域的位置的顶片的皮肤侧表面上的血液润滑性赋予剂的量 润滑性赋予剂，其表面在吸收性物品的厚度方向上重叠。

公开(公告)号：US09056152B2

公开(公告)日：2015-06-16

申请号：US13242445

申请日：2011-09-23

申请人： Steve Kangas ,  James Feng ,  Yen-Lane Chen ,  Maggie Zeng

发明人： Steve Kangas ,  James Feng ,  Yen-Lane Chen ,  Maggie Zeng

IPC分类号： A61L33/00 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61K31/337 ,  C09D5/16 ,  A61F2/02 ,  A61F2/00

CPC分类号： A61K31/436 ,  A61F2/00 ,  A61F2/02 ,  A61K31/337 ,  A61L27/28 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/416 ,  A61L2300/63 ,  C09D5/16

摘要： A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

摘要翻译： 一种具有无聚合物外表面层的医疗装置，其包含选自依维莫司，他克莫司，西罗莫司，佐他莫司，生物利莫霉素和雷帕霉素的结晶药物。 该装置可以通过包括以下步骤的方法制造：提供医疗装置; 将所述药物的溶液施加到所述外表面的所述部分以形成无定形药物的包衣; 并用溶剂蒸气对药物进行蒸汽退火以形成结晶药物; 其中在施加药物溶液之前或之后，在装置的外表面的至少所述部分上施加具有最大粒径为约10μm以下的所述药物的结晶形式的种子层，但是在汽化退火之前， 涂层。

公开(公告)号：US20140364824A1

公开(公告)日：2014-12-11

申请号：US14368886

申请日：2012-12-20

申请人： LIVEDO CORPORATION

发明人： Yoshihisa Ota ,  Motoko Nishida ,  Masatoshi Ikeuchi

IPC分类号： A61L15/60 ,  A61L15/26 ,  A61F13/532

CPC分类号： A61L15/60 ,  A61F13/5323 ,  A61L15/26 ,  A61L15/42 ,  A61L2300/20

摘要： To provide an absorbent article that has a high absorption speed, is unlikely to cause a liquid to remain on a skin-contacting surface, has excellent dry feeling, and is unlikely to cause excreted body fluid to return. The present invention provides an absorbent article comprising an absorber composed of at least one absorbent layer, wherein a water-absorbent resin powder meeting the following requirements (a) to (d) is disposed in an uppermost layer of the absorber: (a) a bulk density: 0.45 g/ml to 0.62 g/ml; (b) an absorption speed by a vortex method: 20 seconds to 50 seconds; (c) a liquid-passing speed under load: 10 seconds or less; and (d) a moisture absorption blocking ratio: 5% or less.

摘要翻译： 为了提供具有高吸收速度的吸收制品，不太可能导致液体残留在皮肤接触表面上，具有优异的干燥感，并且不太可能使排泄体液返回。 本发明提供一种吸收性物品，其特征在于，包括由至少一层吸收体构成的吸收体，其中，在吸收体的最上层配置满足下述（a）〜（d）的要求的吸水性树脂粉末：（a） 堆积密度：0.45g / ml至0.62g / ml; （b）通过涡流法的吸收速度：20秒至50秒; （c）负载下的液体通过速度：10秒以下; 和（d）吸湿阻断率为5％以下。

公开(公告)号：US08686215B2

公开(公告)日：2014-04-01

申请号：US12817371

申请日：2010-06-17

申请人： Mariangela Caputi ,  Luigia D'Ercole ,  Remo Bellucci ,  Nicola D'Alesio ,  Jessica Marcuccitti ,  Adelia Alessandra Tordone

发明人： Mariangela Caputi ,  Luigia D'Ercole ,  Remo Bellucci ,  Nicola D'Alesio ,  Jessica Marcuccitti ,  Adelia Alessandra Tordone

IPC分类号： A61F13/15

CPC分类号： A61L15/46 ,  A61F13/8405 ,  A61L15/26 ,  A61L15/28 ,  A61L2300/20 ,  A61L2300/802 ,  C08L83/04 ,  C08L5/16

摘要： An absorbent article comprising an odor control material comprising at least one inclusion complex of cyclodextrin with an organic compound which is dispersed in a matrix comprising a polysiloxane oil.

摘要翻译： 一种吸收制品，其包含气味控制材料，其包含至少一种环糊精与有机化合物的包合络合物，所述有机化合物分散在包含聚硅氧烷油的基质中。

公开(公告)号：US20130053947A1

公开(公告)日：2013-02-28

申请号：US13242445

申请日：2011-09-23

申请人： Steve Kangas ,  James Feng ,  Yen-Lane Chen ,  Maggie Zeng

发明人： Steve Kangas ,  James Feng ,  Yen-Lane Chen ,  Maggie Zeng

IPC分类号： A61F2/82 ,  B05D7/00 ,  B05D3/10 ,  B05D5/00

CPC分类号： A61K31/436 ,  A61F2/00 ,  A61F2/02 ,  A61K31/337 ,  A61L27/28 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/416 ,  A61L2300/63 ,  C09D5/16

摘要： A medical device having a polymer-free outer surface layer comprising a crystalline drug selected from the group consisting of everolimus, tacrolimus, sirolimus, zotarolimus, biolimus, and rapamycin. The device may be produced by a method comprising the steps of providing a medical device; applying a solution of the drug to said portion of the outer surface to form a coating of amorphous drug; and vapor annealing the drug with a solvent vapor to form crystalline drug; wherein a seed layer of a crystalline form of said drug having a maximum particle size of about 10 μm or less is applied to at least said portion of the outer surface of the device before or after applying the drug solution, but before vapor annealing the amorphous coating.

公开(公告)号：US20120258161A1

公开(公告)日：2012-10-11

申请号：US13525193

申请日：2012-06-15

申请人： Rajesh A. PATEL ,  Louis R. Bucalo ,  Lauren Costantini ,  Sofie Kleppner

发明人： Rajesh A. PATEL ,  Louis R. Bucalo ,  Lauren Costantini ,  Sofie Kleppner

IPC分类号： A61K9/00 ,  A61K31/473 ,  A61P25/14 ,  A61P29/00 ,  A61P15/00 ,  A61K31/56 ,  A61P25/16

CPC分类号： A61L31/16 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1635 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/48 ,  A61K31/485 ,  A61L31/048 ,  A61L31/10 ,  A61L31/125 ,  A61L31/146 ,  A61L2300/20 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2420/04 ,  C08L31/04

摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.

摘要翻译： 本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。 本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。 多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。 该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。

公开(公告)号：US08273367B2

公开(公告)日：2012-09-25

申请号：US10687897

申请日：2003-10-17

申请人： Antonella Pesce ,  Daniela Meo ,  Giovanni Carlucci ,  Achille Di Cintio

发明人： Antonella Pesce ,  Daniela Meo ,  Giovanni Carlucci ,  Achille Di Cintio

IPC分类号： A61F13/00 ,  A61K9/70 ,  A61K9/00 ,  A61K8/02

CPC分类号： A61L15/20 ,  A61L15/46 ,  A61L2300/20 ,  A61L2300/40 ,  A61L2300/802

摘要： The present invention relates to articles to be worn in contact with a mammal body, such as sanitary napkins, pantiliners, nursing pads, baby diapers and the like. The article includes a mint odor-free cooling agent able to convey freshness sensation to the wearer of the article, without the need of modifying body surface temperature.

摘要翻译： 本发明涉及与哺乳动物身体接触的物品，例如卫生巾，短裤护垫，护理垫，婴儿尿布等。 该物品包括能够将新鲜感觉传达给制品穿着者的薄荷无味冷却剂，而不需要改变体表温度。

公开(公告)号：US07736636B2

公开(公告)日：2010-06-15

申请号：US10776383

申请日：2004-02-11

申请人： Shaker Mousa ,  Sarah Mousa

发明人： Shaker Mousa ,  Sarah Mousa

IPC分类号： A61K38/18 ,  A61K31/785 ,  A61K31/4439 ,  A61K31/7076 ,  A61K31/52 ,  A61K31/21

CPC分类号： A61K38/1866 ,  A61K9/0019 ,  A61K31/21 ,  A61K31/4439 ,  A61K31/52 ,  A61K31/7076 ,  A61K31/785 ,  A61K38/1825 ,  A61L2300/20 ,  A61L2300/412 ,  A61K2300/00

摘要： Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of Nicotine, nicotinic acid analogs thereof, their combination with or without other pro-angiogenesis factors, vasodilator, or other therapeutic modalities to promote angiogenesis in the subject. This is composition and combination thereof is applicable to improving wound healing, erectile dysfunction, improving collateral or blood supply in patients with myocardial infarction, stroke, peripheral artery diseases, and other vascular disorders as disclosed.

摘要翻译： 公开了治疗具有与血管发生相关的病症的受试者的方法，包括施用有效量的尼古丁的聚合形式，其烟酸类似物，它们与或不与其它促血管发生因子的组合，血管扩张剂或其它治疗方式以促进血管发生 学科。 这是组合物，其组合可用于改善伤口愈合，勃起功能障碍，改善心肌梗死，中风，外周动脉疾病和其它血管疾病患者的侧支或血液供应。