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公开(公告)号：US06585970B1
公开(公告)日：2003-07-01
申请号：US09706173
申请日：2000-11-02
Applicant: Stephen Donovan
Inventor： Stephen Donovan
IPC: A61K3851
CPC classification number: A61K38/4893
Abstract: A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates the thyroid, thereby reducing a stimulatory effect upon thyroid hormone secretion. Methods for treating calcium metabolism disorders by local administration of a neurotoxin to modulate calcitonin secretion are also disclosed.
Abstract translation: 一种通过局部施用甲状腺毒素等神经毒素治疗甲状腺功能减退的方法，从而降低对甲状腺激素分泌的抑制作用。 通过局部施用神经毒素（例如肉毒杆菌毒素）治疗甲状腺功能亢进的方法，用于支配甲状腺的交感神经节，从而降低对甲状腺激素分泌的刺激作用。 还公开了通过局部施用神经毒素以调节降钙素分泌来治疗钙代谢紊乱的方法。
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2.发明授权Variants of thymidine kinase, nucleic acids encoding them, and methods of using them 失效胸苷激酶的变体，编码它们的核酸，以及使用它们的方法公开(公告)号：US06207150B1
公开(公告)日：2001-03-27
申请号：US09125099
申请日：1998-08-06
Applicant: Joël Crouzet , Francis Blanche , Michel Couder , Béatrice Cameron
Inventor： Joël Crouzet , Francis Blanche , Michel Couder , Béatrice Cameron
IPC: A61K3851
CPC classification number: C12N9/1211 , A01K2217/05 , A61K38/00
Abstract: The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.
Abstract translation: 本发明涉及一种核酸序列，其特征在于其衍生自编码胸苷激酶的野生型核酸序列，所述核酸序列在对应于ATP结合位点的区域中具有至少一个突变，并且方便地具有第二突变 在N-末端区域和/或C-末端区域。 它还涉及野生胸苷激酶的变体及其在基因治疗中的用途。
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公开(公告)号：US06743424B1
公开(公告)日：2004-06-01
申请号：US09706172
申请日：2000-11-02
Applicant: Stephen Donovan
Inventor： Stephen Donovan
IPC: A61K3851
CPC classification number: A61K38/4893
Abstract: A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method for treating hyperthyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a sympathetic ganglion which innervates the thyroid, thereby reducing a stimulatory effect upon thyroid hormone secretion. Methods for treating calcium metabolism disorders by local administration of a neurotoxin to modulate calcitonin secretion are also disclosed.
Abstract translation: 一种通过局部施用甲状腺毒素等神经毒素治疗甲状腺功能减退的方法，从而降低对甲状腺激素分泌的抑制作用。 通过局部施用神经毒素（例如肉毒杆菌毒素）治疗甲状腺功能亢进的方法，用于支配甲状腺的交感神经节，从而降低对甲状腺激素分泌的刺激作用。 还公开了通过局部施用神经毒素以调节降钙素分泌来治疗钙代谢紊乱的方法。
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公开(公告)号：US06517834B1
公开(公告)日：2003-02-11
申请号：US09717828
申请日：2000-11-20
Applicant: Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
Inventor： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
IPC: A61K3851
CPC classification number: C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
Abstract translation: 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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公开(公告)号：US06416755B1
公开(公告)日：2002-07-09
申请号：US09593722
申请日：2000-06-13
Applicant: Olga Bandman , Preeti Lal , Neil C. Corley
Inventor： Olga Bandman , Preeti Lal , Neil C. Corley
IPC: A61K3851
CPC classification number: C12N9/1096 , C12Q1/6883
Abstract: The invention provides a human beta-alanine-pyruvate aminotransferase (HAPA) and polynucleotides which identify and encode HAPA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HAPA.
Abstract translation: 本发明提供了人β-丙氨酸 - 丙酮酸氨基转移酶（HAPA）和识别和编码HAPA的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了治疗或预防与HAPA表达相关的病症的方法。
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Patent Agency Ranking
6.发明授权公开(公告)号：US06787133B2
公开(公告)日：2004-09-07
申请号：US10330872
申请日：2002-12-24
Applicant: Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
Inventor： Scott L. Weinrich , Edward M. Atkinson, III , Serge P. Lichtsteiner , Alain P. Vasserot , Ronald A. Pruzan
IPC: A61K3851
CPC classification number: C12N9/1241 , A61K39/00 , C12Y207/07049 , Y10S435/935
Abstract: This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, intermediate-selectivity matrices, methods that separate molecules based on their size, shape, or buoyant density, and by affinity purification.
Abstract translation: 本发明提供了纯化的端粒酶及其纯化方法。 该方法包括使用几个连续的步骤，包括使用结合带负电荷的分子的基质，结合带正电荷的分子的基质，中间选择性基质，基于其大小，形状或浮力密度分离分子的方法， 并通过亲和纯化。
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公开(公告)号：US06632430B2
公开(公告)日：2003-10-14
申请号：US10334532
申请日：2002-12-30
Applicant: Mingxu Xu , Quinghong Han , Yuying Tan
Inventor： Mingxu Xu , Quinghong Han , Yuying Tan
IPC: A61K3851
CPC classification number: A61K31/7076 , A61K31/198 , A61K38/51
Abstract: Compositions and methods which ameliorate the virulence of bacterial infection are described wherein the active ingredient modulates transmethylation reactions in bacterial cells. Particularly useful compounds are inhibitors of S-adenosyl methionine synthetase (SAMS), of S-adenosyl homocysteine hydrolase (SAHH) and of transmethylases.
Abstract translation: 描述了改善细菌感染的毒力的组合物和方法，其中活性成分调节细菌细胞中的转甲基化反应。 特别有用的化合物是S-腺苷甲硫氨酸合成酶（SAMS），S-腺苷同型半胱氨酸水解酶（SAHH）和转甲基酶的抑制剂。
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公开(公告)号：US06274139B1
公开(公告)日：2001-08-14
申请号：US09340479
申请日：1999-06-30
Applicant: Michael N. Gwynn , Howard Kallendar , Leslie M. Palmer
Inventor： Michael N. Gwynn , Howard Kallendar , Leslie M. Palmer
IPC: A61K3851
Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
Abstract translation: 公开了拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US06251387B1
公开(公告)日：2001-06-26
申请号：US09291488
申请日：1999-04-14
Applicant: Michael N. Gwynn , Howard Kallender
Inventor： Michael N. Gwynn , Howard Kallender
IPC: A61K3851
Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.
Abstract translation: 拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法被公开。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定法。 还公开了用于检测编码链球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US06217863B1
公开(公告)日：2001-04-17
申请号：US09066481
申请日：1999-01-19
Applicant: Ranganathan Godavarti , Ram Sasisekharan , Steffen Ernst , Ganesh Venkataraman , Charles L. Cooney , Robert Langer
Inventor： Ranganathan Godavarti , Ram Sasisekharan , Steffen Ernst , Ganesh Venkataraman , Charles L. Cooney , Robert Langer
IPC: A61K3851
Abstract: Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as as vectors and host cells are provided. Methods for using the modified heparinases are also provided.
Abstract translation: 提供具有改变的结合特异性和活性的修饰的肝素酶。 提供编码与载体和宿主细胞相同的分离的核酸。 还提供了使用改性肝素酶的方法。
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