公开(公告)号：US07332488B2

公开(公告)日：2008-02-19

申请号：US11511129

申请日：2006-08-28

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/52 ,  C07D251/70 ,  C07D401/12 ,  C07D403/12 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US07265114B2

公开(公告)日：2007-09-04

申请号：US11284757

申请日：2005-11-22

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Yeleswarapu Koteswar Rao ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Yeleswarapu Koteswar Rao ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/30 ,  C07D251/46 ,  C07D251/48 ,  C07D251/52 ,  C07D251/54 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US07169784B2

公开(公告)日：2007-01-30

申请号：US10951316

申请日：2004-09-27

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalger Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalger Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Bhatlapenumarthy Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： A61M31/00 ,  A61M2/86 ,  C07D251/70 ,  C07D251/52 ,  C07D251/30

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.