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公开(公告)号:US07456288B2
公开(公告)日:2008-11-25
申请号:US10976284
申请日:2004-10-28
申请人: Yeleswarapu Koteswar Rao , Manojit Pal , Vedula Manohar Sharma , Akella Venkateswarlu , Ram Pillarisetti , Srinivas Padakanti , Kalleda Srinivasa Rao
发明人: Yeleswarapu Koteswar Rao , Manojit Pal , Vedula Manohar Sharma , Akella Venkateswarlu , Ram Pillarisetti , Srinivas Padakanti , Kalleda Srinivasa Rao
IPC分类号: C07D215/04
CPC分类号: C04B35/632 , A61K31/427 , C07D215/56 , C07D239/88 , C07D239/90 , C07D311/30 , C07D401/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要: Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.
摘要翻译: 提供了式(I)化合物,以及包含有效调节炎性反应的化合物的方法和/或组合物,例如由AGE和糖化蛋白质积聚产生的化合物。 还提供了包含有效调节平滑肌细胞增殖的化合物和与之有关的疾病或病症的方法和/或组合物。
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公开(公告)号:US07265114B2
公开(公告)日:2007-09-04
申请号:US11284757
申请日:2005-11-22
申请人: Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Yeleswarapu Koteswar Rao , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人: Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Yeleswarapu Koteswar Rao , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号: C07D251/30 , C07D251/46 , C07D251/48 , C07D251/52 , C07D251/54 , A61K31/53 , A61P35/00
CPC分类号: A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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